|
rs290227
|
|
|
0.810 |
GeneticVariation |
BEFREE |
We suggested a novel association of the VaD susceptibility with an intronic variant of rs290227 in the SYK gene.
|
23480133 |
2013 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The MTHFR C677T is not associated with an increased risk of vascular dementia or Alzheimer's disease.
|
10855603 |
2000 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The MTHFR C677T polymorphism (mainly TT genotype) is associated with developing VaD in general populations or Asian populations.
|
20441995 |
2010 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
To elucidate the specific role of the TT genotype of MTHFR in the development of cerebral infarction with and without cognitive impairment, we determined the prevalence of hyperhomocyst(e)inemia and the C677T genotypes of MTHFR in 143 patients with vascular dementia, 122 patients with cerebral infarction, and 217 healthy subjects matched for age and sex.
|
10938012 |
2000 |
|
rs1217691063
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We identified APOE ɛ2/ɛ3/ɛ4 and additional four genetic polymorphisms including MTHFR C677T, PON1 L55M, TGF-β1 +29C/T, and TNF-α -850C/T associated with VaD.
|
25835425 |
2015 |
|
rs4986938
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In haplotype analyses, the ERβ haplotype containing the polymorphism rs944050 variant allele and the polymorphism rs4986938 wild-type allele was associated with VaD (odds ratio = 1.70, 95% confidence interval = 1.03-2.84).
|
22183267 |
2012 |
|
rs4986938
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The ESR2 rs4986938 polymorphism is associated with susceptibility for VaD in elderly Jewish women.
|
19473078 |
2009 |
|
rs5882
|
|
|
0.020 |
GeneticVariation |
BEFREE |
CETP I405V polymorphism is likely a risk factor for AD and VaD in our cohort, independent of APOEɛ4 status.
|
29332048 |
2018 |
|
rs5882
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Neither the C-629A (P = 0.169) nor the I405V (P = 0.840) polymorphism was associated with VD risk in the whole sample.
|
19184337 |
2009 |
|
rs1051266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No direct association was found between variant (G) allele or genotype of rs1051266 with AD and VaD cases.
|
24554143 |
2014 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current results suggested that AGT T235M polymorphism might be a risk factor of vascular dementia.
|
16603315 |
2006 |
|
rs1333049
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Altogether, our data indicate for the first time that the C allele of rs1333049</span> in the vascular disease susceptibility locus is associated with VaD and LOAD, independent of traditional risk factors and the APOE ε4 genotype.
|
19664850 |
2011 |
|
rs140701
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward.
|
20502016 |
2010 |
|
rs17501010
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For patients with type 2 diabetes the odds ratio of VaD increased significantly in GC+CC genotypes of rs893051 (OR=12.57, P<0.0001) and GT+TT of rs17501010 (OR=5.33, P=0.01).
|
28273404 |
2017 |
|
rs1799990
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Codon 129 (M129V) and 219 (Q219K) polymorphisms in Korean VaD patients were found in the open reading frame of PRNP.
|
17570906 |
2007 |
|
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Pro10Leu of TGFB1 might be a risk factor of ischemic stroke and vascular dementia, especially for SVO in females.
|
16990569 |
2006 |
|
rs1800795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While rs1800795 (CC or GC) genotypes alone increased the odds of developing VaD </span>by 2.2-fold, the presence of CC genotype of rs1801131 nullified this effect.
|
22015309 |
2012 |
|
rs1801131
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this case-control study, we examined C677T and A1298C (rs1801133 and rs1801131) polymorphism in the methylenetetrahydrofolate reductase (MTHFR) genes and their correlation with plasma levels of homocysteine (Hcy) in AD and VaD cases and evaluated the gene-gene interaction (epistasis) with IL-6-174 G/C (rs1800795).
|
22015309 |
2012 |
|
rs1801133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this case-control study, we examined C677T and A1298C (rs1801133 and rs1801131) polymorphism in the methylenetetrahydrofolate reductase (MTHFR) genes and their correlation with plasma levels of homocysteine (Hcy) in AD and VaD cases and evaluated the gene-gene interaction (epistasis) with IL-6-174 G/C (rs1800795).
|
22015309 |
2012 |
|
rs3813034
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward.
|
20502016 |
2010 |
|
rs4795541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward.
|
20502016 |
2010 |
|
rs4925
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Asp/Asp genotype of the Ala140Asp polymorphism of the GSTO1 gene has been alleged to increase the risk of vascular dementia.
|
17717316 |
2007 |
|
rs662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The interaction between PON1 genes (rs662 and rs85460) and ApoE genes showed synergistic epistasis in altering the odds of significantly having both AD and VaD.
|
24965284 |
2014 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current results suggested that AGT T235M polymorphism might be a risk factor of vascular dementia.
|
16603315 |
2006 |
|
rs7493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
(3-8) The importance of cardiovascular risk factors in the pathomechanism of Alzheimer's disease (AD) and vascular dementia (VD)(9-13) prompted us to examine the genetic effect of PON2 gene codon 311 (Cys-->Ser; PON2*S) polymorphism and the relationship between the PON2*S allele and the other dementia risk factor, the apoE polymorphism in these dementias.
|
11803456 |
2002 |