|
rs1800795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While rs1800795 (CC or GC) genotypes alone increased the odds of developing VaD </span>by 2.2-fold, the presence of CC genotype of rs1801131 nullified this effect.
|
22015309 |
2012 |
|
rs1801131
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this case-control study, we examined C677T and A1298C (rs1801133 and rs1801131) polymorphism in the methylenetetrahydrofolate reductase (MTHFR) genes and their correlation with plasma levels of homocysteine (Hcy) in AD and VaD cases and evaluated the gene-gene interaction (epistasis) with IL-6-174 G/C (rs1800795).
|
22015309 |
2012 |
|
rs1801133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this case-control study, we examined C677T and A1298C (rs1801133 and rs1801131) polymorphism in the methylenetetrahydrofolate reductase (MTHFR) genes and their correlation with plasma levels of homocysteine (Hcy) in AD and VaD cases and evaluated the gene-gene interaction (epistasis) with IL-6-174 G/C (rs1800795).
|
22015309 |
2012 |
|
rs3813034
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward.
|
20502016 |
2010 |
|
rs4795541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward.
|
20502016 |
2010 |
|
rs4925
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Asp/Asp genotype of the Ala140Asp polymorphism of the GSTO1 gene has been alleged to increase the risk of vascular dementia.
|
17717316 |
2007 |
|
rs662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The interaction between PON1 genes (rs662 and rs85460) and ApoE genes showed synergistic epistasis in altering the odds of significantly having both AD and VaD.
|
24965284 |
2014 |
|
rs699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current results suggested that AGT T235M polymorphism might be a risk factor of vascular dementia.
|
16603315 |
2006 |
|
rs7493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
(3-8) The importance of cardiovascular risk factors in the pathomechanism of Alzheimer's disease (AD) and vascular dementia (VD)(9-13) prompted us to examine the genetic effect of PON2 gene codon 311 (Cys-->Ser; PON2*S) polymorphism and the relationship between the PON2*S allele and the other dementia risk factor, the apoE polymorphism in these dementias.
|
11803456 |
2002 |
|
rs769665945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While the ACE I/D, AT1R A1166C, and PAI-1 4G/5G did not contribute to the genetic susceptibility to vascular dementia (P>0.05), a significant association with vascular dementia was shown in the T235M polymorphism of AGT.
|
16603315 |
2006 |
|
rs854560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified APOE ɛ2/ɛ3/ɛ4 and additional four genetic polymorphisms including MTHFR C677T, PON1 L55M, TGF-β1 +29C/T, and TNF-α -850C/T associated with VaD.
|
25835425 |
2015 |
|
rs893051
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For patients with type 2 diabetes the odds ratio of VaD increased significantly in GC+CC genotypes of rs893051 (OR=12.57, P<0.0001) and GT+TT of rs17501010 (OR=5.33, P=0.01).
|
28273404 |
2017 |
|
rs944050
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphism rs944050 in the ERβ gene was associated with an increased risk of VaD in Chinese Han women.
|
22183267 |
2012 |
|
rs951660
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele, A, of its intronic SNP 'rs951660' might induce a delayed splicing and thus increase the susceptibility to VaD.
|
22111664 |
2013 |