Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4986938
rs4986938
ESR2
0.020 GeneticVariation BEFREE In haplotype analyses, the ERβ haplotype containing the polymorphism rs944050 variant allele and the polymorphism rs4986938 wild-type allele was associated with VaD (odds ratio = 1.70, 95% confidence interval = 1.03-2.84). 22183267

2012
dbSNP: rs944050
rs944050
ESR2
0.010 GeneticVariation BEFREE The polymorphism rs944050 in the ERβ gene was associated with an increased risk of VaD in Chinese Han women. 22183267

2012
dbSNP: rs290227
rs290227
SYK
G 0.810 GeneticVariation GWASDB We suggested a novel association of the VaD susceptibility with an intronic variant of rs290227 in the SYK gene. 23480133

2013
dbSNP: rs290227
rs290227
SYK
G 0.810 GeneticVariation GWASCAT We suggested a novel association of the VaD susceptibility with an intronic variant of rs290227 in the SYK gene. 23480133

2013
dbSNP: rs290227
rs290227
SYK
0.810 GeneticVariation BEFREE We suggested a novel association of the VaD susceptibility with an intronic variant of rs290227 in the SYK gene. 23480133

2013
dbSNP: rs1051266
rs1051266
SLC19A1
0.010 GeneticVariation BEFREE No direct association was found between variant (G) allele or genotype of rs1051266 with AD and VaD cases. 24554143

2014
dbSNP: rs662
rs662
PON1
0.010 GeneticVariation BEFREE The interaction between PON1 genes (rs662 and rs85460) and ApoE genes showed synergistic epistasis in altering the odds of significantly having both AD and VaD. 24965284

2014
dbSNP: rs1217691063
rs1217691063
MTHFR
0.040 GeneticVariation BEFREE We identified APOE ɛ2/ɛ3/ɛ4 and additional four genetic polymorphisms including MTHFR C677T, PON1 L55M, TGF-β1 +29C/T, and TNF-α -850C/T associated with VaD. 25835425

2015
dbSNP: rs854560
rs854560
PON1
0.010 GeneticVariation BEFREE We identified APOE ɛ2/ɛ3/ɛ4 and additional four genetic polymorphisms including MTHFR C677T, PON1 L55M, TGF-β1 +29C/T, and TNF-α -850C/T associated with VaD. 25835425

2015
dbSNP: rs17501010
rs17501010
CLDN1 ; LOC107986170
0.010 GeneticVariation BEFREE For patients with type 2 diabetes the odds ratio of VaD increased significantly in GC+CC genotypes of rs893051 (OR=12.57, P<0.0001) and GT+TT of rs17501010 (OR=5.33, P=0.01). 28273404

2017
dbSNP: rs893051
rs893051
CLDN1
0.010 GeneticVariation BEFREE For patients with type 2 diabetes the odds ratio of VaD increased significantly in GC+CC genotypes of rs893051 (OR=12.57, P<0.0001) and GT+TT of rs17501010 (OR=5.33, P=0.01). 28273404

2017
dbSNP: rs5882
rs5882
CETP
0.020 GeneticVariation BEFREE CETP I405V polymorphism is likely a risk factor for AD and VaD in our cohort, independent of APOEɛ4 status. 29332048

2018
dbSNP: rs117834366
rs117834366
CNTNAP2
A 0.700 GeneticVariation GWASCAT Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project. 31473137

2019
dbSNP: rs429358
rs429358
APOE
C 0.700 GeneticVariation GWASCAT Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project. 31473137

2019