Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10010131
rs10010131
WFS1
0.010 GeneticVariation BEFREE We genotyped the WFS1 SNPs rs10010131, rs752854 and rs734312 (H611R) in 3,548 DPP participants and performed Cox regression analysis using genotype, intervention and their interactions as predictors of diabetes incidence. 18060660

2008
dbSNP: rs1004446
rs1004446
IGF2 ; IGF2-AS ; INS-IGF2
0.010 GeneticVariation BEFREE Three single nucleotide polymorphisms were associated with increased diabetes risk (rs10517086_A [<i>P</i> = 0.03], rs1534422_G [<i>P</i> = 0.006], and rs2327832_G [<i>P</i> = 0.03] in <i>TNFAIP3</i>) and one with decreased risk (rs1004446_A in <i>INS</i> [<i>P</i> = 0.006]). 28903990

2017
dbSNP: rs10084572
rs10084572
LOC105372829
T 0.700 GeneticVariation GWASCAT Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program. 31451708

2019
dbSNP: rs10116772
rs10116772
GLIS3
0.010 GeneticVariation BEFREE Variants in strong correlation with rs10116772 have been associated with elevated plasma glucose levels and diabetes. 29436472

2018
dbSNP: rs1013773109
rs1013773109
GRB14
0.010 GeneticVariation BEFREE The cancer-associated FGFR4-G388R polymorphism enhances pancreatic insulin secretion and modifies the risk of diabetes. 23747250

2013
dbSNP: rs1022113606
rs1022113606
SOD3
0.010 GeneticVariation BEFREE We used the prospective Copenhagen General Population Study and Copenhagen City Heart Study and genotyped 95,871 individuals for the rs1799895 R213G variation in the SOD3 gene, of which 4498 had diabetes. 26844281

2015
dbSNP: rs10224002
rs10224002
PRKAG2
A 0.700 GeneticVariation GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844

2018
dbSNP: rs10224210
rs10224210
PRKAG2
T 0.700 GeneticVariation GWASCAT Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program. 31451708

2019
dbSNP: rs1024611
rs1024611 		0.010 GeneticVariation BEFREE Multivariate Cox regression analysis, taking into the account the recipient's sex, age and BMI, as well as the number of G alleles of the CCL2 rs1024611 polymorphism, revealed that this polymorphism is an independent risk factor for post-transplant diabetes. 26802601

2016
dbSNP: rs1033656351
rs1033656351
P2RX4
0.010 GeneticVariation BEFREE In the Prevalence, Prediction, and Prevention of Diabetes in Botnia study, the minor allele in the missense functional variant rs1718119 (A348T) in P2RX7 was associated with increased insulin sensitivity and secretion, consistent with its known effect on increased pore function. 25719930

2015
dbSNP: rs1036483919
rs1036483919
GCK
0.020 GeneticVariation BEFREE Mutation p.T130I was associated with both early-onset and late-onset diabetes and caused downregulated HNF4A expression, whereas HNF1A polymorphisms p.I27L and p.S487N were associated with the age of diagnosis of diabetes. 26981542

2016
dbSNP: rs1036483919
rs1036483919
GCK
0.020 GeneticVariation BEFREE The heterozygous T130I mutation was the unique functional gene variation that could explain diabetes phenotype. 25361053

2014
dbSNP: rs1036915
rs1036915
NTRK2
0.010 GeneticVariation BEFREE Of the 12 common genetic variants examined, the rs1036915 (located in 3'UTR) and rs1187274 (located in intron-14), present in perfect linkage disequilibrium, exhibited an association (P = 0.017) with eGFR after accounting for the effects of age, sex, diabetes, diabetes duration, systolic blood pressure and blood pressure medication. 25885044

2015
dbSNP: rs1037733674
rs1037733674
GCG ; LOC101929532
0.010 GeneticVariation BEFREE Patients with diabetes and carriers of Gly40Ser showed basal C-peptide levels significantly lower than noncarriers (0.70 ng/mL versus 1.50 ng/mL, p = 0.008). 11961492

2002
dbSNP: rs10401969
rs10401969
SUGP1
0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247

2016
dbSNP: rs1042488900
rs1042488900
ATF6
0.010 GeneticVariation BEFREE No association with diabetes was showed in the meta-analyses of other six genetic variants, including SLC2A10 rs2335491, ATF6 rs2070150, KLF11 rs35927125, CASQ1 rs2275703, GNB3 C825T, and IL12B 1188A/C. 23922971

2013
dbSNP: rs1042522
rs1042522
TP53
0.020 GeneticVariation BEFREE Risk of cancer specific mortality, cardiovascular mortality, and respiratory mortality were not associated with Arg72Pro genotype overall; however, in exploratory subgroup analyses, genotype-associated risks of malignant melanoma and diabetes were altered. 28336930

2017
dbSNP: rs1042522
rs1042522
TP53
0.020 GeneticVariation BEFREE We analyzed the presence of SNP rs2228000 from XPC and rs1042522 from p53; and the relationship between risk factors such as smoking, alcohol intake, hypertension or diabetes. 27248495

2016
dbSNP: rs1042615
rs1042615
AVPR1A
0.010 GeneticVariation BEFREE The rs1042615 T allele is associated with features resembling the phenotype of the V1aR(-/-) mouse, including uncoupling of the usual direct relation between glucose and triglycerides and an increased prevalence of diabetes in subjects with a high fat intake or who are overweight. 19056558

2009
dbSNP: rs1042713
rs1042713
ADRB2
0.010 GeneticVariation BEFREE On the other hand, hypertensive cases, whether being isolated or associated with obesity and/or diabetes, showed a nonsignificant difference from controls in relation to all genotypic variants related to the ADRB2 G46A polymorphism (p>0.05). 22731644

2012
dbSNP: rs1042714
rs1042714
ADRB2
0.010 GeneticVariation BEFREE Gln27Glu variant of the beta2-adrenergic receptor gene is not associated with obesity and diabetes in Japanese-Americans. 11288039

2001
dbSNP: rs1044250
rs1044250
ANGPTL4
0.010 GeneticVariation BEFREE We genotyped 629 subjects with and without a family history of diabetes for the 4 single nucleotide polymorphisms (SNPs) rs4076317, rs2278236, rs1044250, and rs11672433 and performed correlational analyses with metabolic traits. 18442626

2008
dbSNP: rs1044498
rs1044498
ENPP1
0.010 GeneticVariation BEFREE We assessed rs1044498 (K173Q) located in the ENPP1 gene for association with diabetes nephropathy among 201 diabetic subjects without nephropathy and 215 diabetic subjects with nephropathy in the Taiwanese population. 21198320

2011
dbSNP: rs10455872
rs10455872
LPA
0.010 GeneticVariation BEFREE We tested associations of tertiles of lipoprotein(a) concentration in plasma and two LPA single-nucleotide polymorphisms ([SNPs] rs10455872 and rs3798220) with all-cause mortality and cardiovascular mortality by Cox regression analysis and with severity of disease by generalised linear modelling, with and without adjustment for age, sex, diabetes diagnosis, systolic blood pressure, BMI, smoking status, estimated glomerular filtration rate, LDL-cholesterol concentration, and use of lipid-lowering therapy. 28566218

2017
dbSNP: rs1047891
rs1047891
CPS1
A 0.700 GeneticVariation GWASCAT Mapping eGFR loci to the renal transcriptome and phenome in the VA Million Veteran Program. 31451708

2019