Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247

2016

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE These results were consistent with the pooled results from our meta-analysis study (for diabetes, rs8050136, P = 1.3 x 10(-3); rs9939609, P = 9.8 x 10(-4); for obesity, rs8050136, P = 2.2 x 10(-7); rs9939609, P = 9.0 x 10(-9)). 20057365

2010

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE For white participants, the FTO rs9939609 A allele was associated with an increased risk of diabetes (odds ratio (OR) = 1.19, p<0.001) and obesity (OR = 1.22, p<0.001) under an additive genetic model that was similar for all of the SNPs analyzed. 20502638

2010

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE Among 22,799 individuals (44-74 years) in the population-based Malmö diet and cancer cohort that were genotyped for rs9939609 in FTO and had information on dietary intake (from a modified diet history method) and no history of diabetes, cancer or cardiovascular disease, 2255 deaths (including 1100 cancer and 674 cardiovascular deaths) occurred during 12.0 years of follow-up. 21179003

2011

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE A common variant, rs9939609, in the FTO (fat mass and obesity) gene is associated with adiposity in Europeans, explaining its relationship with diabetes. 21294771

2011

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) in the fat mass and obesity-associated (FTO) gene, especially the common rs9939609 (A/T) SNP, are associated with body mass index (BMI), diabetes, and metabolic syndrome (MetS). 21741858

2012

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE The rs9939609 polymorphism in the FTO gene is related to abnormal glucose levels and with LAP, a surrogate marker of diabetes and cardiovascular risk in postmenopause. 21868005

2011

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238). 22466342

2012

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE This was a cross-sectional study of 236 patients with type 2 diabetes (age 60.0 ± 10.3 years; diabetes duration 12.7 ± 8.2 years; 53.4% females) who were genotyped for FTO rs9939609. 23689376

2013

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE RESULTS Genotype distributions of rs10811661 (CDKN2A/2B), rs7195539, rs8050136, and rs9939609 (FTO) and allele frequencies of rs8050136 and rs9939609 differed significantly between diabetes and control groups (all P<0.05). 26873362

2016

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE The age of developing diabetes and FTO polymorphisms (rs9939609, rs1421085, and rs9930506). 28585683

2017

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE Additionally, both omentin Val109Asp and FTO rs9939609 polymorphisms were significantly positively correlated to familial history of diabetes (P = 0.046 and P = 0.024, respectively). 31200723

2019

dbSNP: rs9939609
rs9939609
FTO
0.800 GeneticVariation BEFREE Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192). 31823921

2019

dbSNP: rs1333049
rs1333049
0.740 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247

2016

dbSNP: rs1333049
rs1333049
0.740 GeneticVariation BEFREE Significant associations were observed between 2 SNPs, rs1333049 on chromosome 9p21 and rs17465637 on chromosome 1q41, and MI, with odds ratios adjusted for age, sex, diabetes, hypertension and smoking habit of 1.47 (95% confidence interval (CI), 1.15-1.89; corrected p=0.006) and 1.45 (95%CI, 1.15-1.83; corrected p=0.006) for rs1333049 and rs17465637, respectively. 18654002

2008

dbSNP: rs1333049
rs1333049
0.740 GeneticVariation BEFREE Genotyping of variant rs1333049 on chromosome 9p21.3 was performed in 2387 patients with and without diabetes who were undergoing coronary angiography to evaluate suspected or established CAD. 21362310

2011

dbSNP: rs1333049
rs1333049
0.740 GeneticVariation BEFREE For CHD patients, rs1333049 decreased the risk of diabetes under heterozygote (p = .014) and dominant (p = .024) models. 31496134

2019

dbSNP: rs1333049
rs1333049
0.740 GeneticVariation BEFREE Genotype CC of rs1333049 was significantly associated with both elevated CRP levels and decreased HDL concentrations after univariate (p = 0.028, p = 0.012) and multivariate analysis (p = 0.041, p = 0.023) stratified for age, gender, body mass index, smoking, diabetes, and severe periodontitis. 31770616

2020

dbSNP: rs780094
rs780094
0.740 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247

2016

dbSNP: rs780094
rs780094
0.740 GeneticVariation BEFREE Our findings indicate rs780094 has independent associations with multiple metabolic traits as well as incident diabetes, but not incident CHD or stroke. 20661421

2010

dbSNP: rs780094
rs780094
0.740 GeneticVariation BEFREE The intronic single-nucleotide polymorphism (SNP) rs780094 (intron 16) and the missense SNP rs1260326 (P446L) in the GCKR gene are strongly associated with increased circulating triglyceride and C-reactive protein levels and, paradoxically, reductions in diabetes incidence, fasting glucose levels, and insulin resistance. 21525158

2011

dbSNP: rs780094
rs780094
0.740 GeneticVariation BEFREE This study provides the first evidence that GCKR rs780094, a single-nucleotide polymorphism related to diabetes, may be associated with pancreatic cancer risk. 22015968

2012

dbSNP: rs780094
rs780094
0.740 GeneticVariation BEFREE In the Danish MONICA study four gene variants were significantly associated with incident CVD independently of known diabetes status at baseline; SLC2A2 rs11920090 (HR 1.147, 95% CI 1.027-1.283 , P = 0.0154), C2CD4A rs7172432 (1.112, 1.027-1.205 , P = 0.0089), GCKR rs780094 (1.094, 1.007-1.188 , P = 0.0335) and C2CD4B rs11071657 (1.092, 1.007-1.183 , P = 0.0323). 23185617

2012

dbSNP: rs587783672
rs587783672
0.720 GeneticVariation BEFREE At follow-up of the TNDM patients with genetic alterations, 43% developed diabetes or impaired glucose tolerance in later life (one with 6q24 duplication and two with N48D and E227K mutations at KCNJ11 gene). 17490422

2007

dbSNP: rs587783672
rs587783672
0.720 GeneticVariation BEFREE Only one mutation (p.Glu227Lys in KCNJ11) co-segregated with diabetes in the family (with a LOD-score of 3.68). 22701567

2012