|
rs1364181648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ZnT8 Arg325Trp polymorphism influences zinc transporter expression and cytokine production in PBMCs from patients with diabetes.
|
30142362 |
2018 |
|
rs142727972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A c.839C>T (p.(Thr280Met)) variant (rs200998587:C>T, risk allele frequency = 0.03) in RBPJL, identified only in Amerindian-derived populations, associated with T2D (OR = 1.60[1.21-2.13] per Met allele, P = 0.001) and age of diabetes onset (HR = 1.40[1.14-1.72], P = 0.001).
|
29302047 |
2018 |
|
rs146488435
|
|
|
0.010 |
GeneticVariation |
BEFREE |
KCNH6 p.P235L heterozygous mutation co-separated with diabetes in a four-generation pedigree.
|
30590050 |
2018 |
|
rs147028059
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we describe a 13-years-old child with LD due to a <i>NHLRC1</i> (c.386C > A, p.Pro129His) mutation, who has developed diabetes mellitus and was treated with metformin.
|
30701169 |
2018 |
|
rs1554635488
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In summary, the p.Ser64Phe missense <i>MAFA</i> mutation leads to familial insulinomatosis or diabetes by impacting MAFA protein stability and transactivation ability.
|
29339498 |
2018 |
|
rs1800871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When we stratified data based on ethnicity of participants, we found that the rs1800871 polymorphism was significantly correlated with DM in Caucasians, the rs1800872 polymorphism was significantly correlated with DM in Asians, and the rs1800896 polymorphism was significantly correlated with DM in both Caucasians and Asians.
|
30223288 |
2018 |
|
rs1800872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When we stratified data based on ethnicity of participants, we found that the rs1800871 polymorphism was significantly correlated with DM in Caucasians, the rs1800872 polymorphism was significantly correlated with DM in Asians, and the rs1800896 polymorphism was significantly correlated with DM in both Caucasians and Asians.
|
30223288 |
2018 |
|
rs1800896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When we stratified data based on ethnicity of participants, we found that the rs1800871 polymorphism was signific</span>antly correlated with DM in Caucasians, the rs1800872 polymorphism was significantly correlated with DM in Asians, and the rs1800896 polymorphism was significantly correlated with DM in both Caucasians and Asians.
|
30223288 |
2018 |
|
rs181914721
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We propose that A137T in ADAMTSL3 is a candidate mutation for susceptibility to diabetes in this family and in the Japanese population.
|
29162515 |
2018 |
|
rs200998587
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A c.839C>T (p.(Thr280Met)) variant (rs200998587:C>T, risk allele frequency = 0.03) in RBPJL, identified only in Amerindian-derived populations, associated with T2D (OR = 1.60[1.21-2.13] per Met allele, P = 0.001) and age of diabetes onset (HR = 1.40[1.14-1.72], P = 0.001).
|
29302047 |
2018 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multifactor dimensionality reduction analysis (MDR) revealed that synergistic interactions between CYP3A5*3 and ABCB1 2677 G>T/A as the determinants of risk for post-transplant diabetes.
|
29621269 |
2018 |
|
rs2070744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our findings indicate that rs891512, rs1799983, rs2070744, and rs869109213 polymorphisms may serve as genetic biomarkers of DM, while rs1799983, rs2070744, and rs869109213 polymorphisms may contribute to the development of vascular complications in DM.
|
30140993 |
2018 |
|
rs2073932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The E and G alleles and AA genotype of <i>ADAMTS13</i> Q448E, rs2073932, and rs652600, respectively, were independently associated with DM (odds ratio [OR] [95% confidence interval (CI)] = 2.5 [1.1, 5.6], 2.3 [1.0, 5.2], and 4.7 [1.2, 18.6], respectively).
|
30181741 |
2018 |
|
rs2243250
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our logistic regression analysis adjusted for gender, age, diabetes duration, and glycated hemoglobin showed no association between rs2243250 and the risk for DN (OR 1.06; CI 0.37-3.05; p = 0.9).
|
29514038 |
2018 |
|
rs225015
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the AMI cohort, associations between: DIO1 rs12095080 and hypertension; DIO2 rs225015 and diabetes mellitus; and the OATP1C1 rs974453 genotype, and AMI type were established.
|
29641285 |
2018 |
|
rs2296966
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele T of rs2296966 was associated with higher prevalence and incidence of diabetes, an earlier onset of diabetes, and higher 2-h glucose during oral glucose tolerance test.
|
30002559 |
2018 |
|
rs2383208
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Islets from donors without diabetes (<i>n</i> = 95) were tested for SNP genotype (rs10811661, rs2383208, rs564398, and rs10757283), gene expression (<i>p14</i>, <i>p15</i>, <i>p16</i>, <i>MTAP</i>, <i>ANRIL</i>, <i>PCNA</i>, <i>KI67</i>, and <i>CCND2</i>), insulin secretion (<i>n</i> = 61), and β-cell proliferation (<i>n</i> = 47).
|
29432124 |
2018 |
|
rs2735940
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Possible association of the TERT promoter polymorphisms rs2735940, rs7712562 and rs2853669 with diabetes mellitus in obese elderly Polish population: results from the national PolSenior study.
|
29938393 |
2018 |
|
rs2853669
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Possible association of the TERT promoter polymorphisms rs2735940, rs7712562 and rs2853669 with diabetes mellitus in obese elderly Polish population: results from the national PolSenior study.
|
29938393 |
2018 |
|
rs2920502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GG genotype of rs2920502 in PPAR<i>γ</i> had a decreased risk for diabetes.
|
29849618 |
2018 |
|
rs3025039
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, rs699947 positively correlated with LDL-cholesterol, and rs3025039 positively correlated with diabetes duration, but negatively with HbA1c and serum triglycerides.
|
29533820 |
2018 |
|
rs3134069
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It remains to be determined whether rs3134069 is associated with ischemic stroke in the general population or populations without diabetes.
|
29501268 |
2018 |
|
rs34459162
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among whites, rs34459162, a novel missense single nucleotide polymorphism (SNP) in <i>RCN3</i>, was associated with fructosamine (<i>P</i> = 5.3 × 10<sup>-9</sup>) and rs1260236, a known diabetes-related missense mutation in <i>GCKR</i>, was associated with percent glycated albumin (<i>P</i> = 5.9 × 10<sup>-9</sup>) and replicated in CARDIA.
|
29844224 |
2018 |
|
rs483353044
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Following an oral glucose tolerance test in the presence of metformin, carriers of the p.E508K variant with diabetes had a lower maximum insulin peak and total and incremental insulin AUC value as compared with noncarriers with diabetes (<i>P</i> < 0.05).
|
29844095 |
2018 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that prevalence of A/G genotype of TLR4 rs4986790 and CT genotype of TLR4 rs4986791 are significantly higher in patients of diabetes with UTI in comparison to diabetic patients without UTI.
|
29066305 |
2018 |