|
rs200998587
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A c.839C>T (p.(Thr280Met)) variant (rs200998587:C>T, risk allele frequency = 0.03) in RBPJL, identified only in Amerindian-derived populations, associated with T2D (OR = 1.60[1.21-2.13] per Met allele, P = 0.001) and age of diabetes onset (HR = 1.40[1.14-1.72], P = 0.001).
|
29302047 |
2018 |
|
rs1308346790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A c.839C>T (p.(Thr280Met)) variant (rs200998587:C>T, risk allele frequency = 0.03) in RBPJL, identified only in Amerindian-derived populations, associated with T2D (OR = 1.60[1.21-2.13] per Met allele, P = 0.001) and age of diabetes onset (HR = 1.40[1.14-1.72], P = 0.001).
|
29302047 |
2018 |
|
rs5443
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A case-control association study of the C825T polymorphism with diabetes using multiple logistic regression analysis showed a significant association of the genotypes TT+TC with an odds ratio of 0.62 (p=0.008) independent of age, gender, and BMI.
|
18656447 |
2008 |
|
rs137853240
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A combination of abnormal splicing and reduced activity of the G319S protein may explain the diabetes susceptibility.
|
18586913 |
2008 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
16393309 |
2006 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
16393309 |
2006 |
|
rs1801282
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
17763950 |
2008 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
17763950 |
2008 |
|
rs9939609
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A common variant, rs9939609, in the FTO (fat mass and obesity) gene is associated with adiposity in Europeans, explaining its relationship with diabetes.
|
21294771 |
2011 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A comprehensive literature search was conducted to collect data from all case-control observational studies that investigated association of C677T polymorphism in MTHFR gene with DM or DN in a Chinese population.
|
22209973 |
2012 |
|
rs3115757
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A correlation between rs3115757 and rs2281068 and diabetes was observed in first batch.
|
27831922 |
2016 |
|
rs4607517
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A genetic variant near the glucokinase gene (rs4607517) was significantly associated with progression to prediabetes or diabetes (hazard ratio 1·27, 1·16-1·38; p=1·70 × 10(-7)).
|
26577716 |
2016 |
|
rs57922
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A genome-wide association study in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial identified two markers (rs57922 and rs9299870) that were significantly associated with cardiovascular mortality during intensive glycemic control and could potentially be used, when combined into a genetic risk score (GRS), to identify patients with diabetes likely to derive benefit from intensive control rather than harm.
|
29183908 |
2018 |
|
rs9299870
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A genome-wide association study in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial identified two markers (rs57922 and rs9299870) that were significantly associated with cardiovascular mortality during intensive glycemic control and could potentially be used, when combined into a genetic risk score (GRS), to identify patients with diabetes likely to derive benefit from intensive control rather than harm.
|
29183908 |
2018 |
|
rs13333226
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
|
29703844 |
2018 |
|
rs10224002
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
|
29703844 |
2018 |
|
rs11622435
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
|
29703844 |
2018 |
|
rs11864909
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
|
29703844 |
2018 |
|
rs1974990
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
|
29703844 |
2018 |
|
rs7222331
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
|
29703844 |
2018 |
|
rs77559408
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes.
|
29703844 |
2018 |
|
rs58542926
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A glutamate-to-lysine variant (rs58542926-T) in transmembrane 6 superfamily member 2 (<i>TM6SF2</i>) is associated with increased fatty liver disease and diabetes in conjunction with decreased cardiovascular disease risk.
|
28539357 |
2017 |
|
rs121908279
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A heterozygous R6C mutation cosegregated with diabetes in a MODY family and is probably pathogenic, but the L68M substitution identified in a patient with young-onset type 2 diabetes may be a rare nonfunctional variant.
|
18162506 |
2008 |
|
rs7533564
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A locus on chromosome 1, rs7533564 (P = 1.9 × 10(-9)), was associated with skin intrinsic fluorescence measured by SCOUT DS (excitation 375 nm, emission 435-655 nm), which remained significant after adjustment for time-weighted HbA1c (P = 1.7 × 10(-8)). rs7533564 was associated with mean HbA1c in meta-analysis (P = 0.0225), mean glycated albumin (P = 0.0029), and glyoxal hydroimidazolones (P = 0.049), an AGE measured in skin biopsy collagen, in DCCT. rs7533564 was not associated with diabetes complications in DCCT/EDIC or with SF in subjects without diabetes (nondiabetic [ND]) (N = 8,721).
|
27207532 |
2016 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of 4,245 case and 5,982 control subjects indicated a null association of C282Y with diabetes risk, whereas carriers of H63D or the compound heterozygotes had marginally increased risk (odds ratio [OR] 1.11 [95% CI 1.00-1.25] and 1.60 [0.99-2.60], respectively).
|
16306377 |
2005 |