|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Thus, the present study aimed to investigate the association between rs13266634 polymorphism and T2DM in Fars province, Southern Iran and compare the results with other populations.
|
24449369 |
2014 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Seven SNPs in six genes known to increase the risk of T2DM in Caucasians were genotyped by means of TaqMan assays in 235 kidney transplant patients medicated with tacrolimus: rs4402960 and rs1470579 in IGF2BP2; rs1111875 in HHEX; rs10811661 upstream of CDKN2A/B; rs13266634 in SLC30A8; rs1801282 in PPARG; rs5215 in KCNJ11.
|
22569928 |
2012 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A significant association for SNP rs13266634 was observed between patients with type 2 diabetes and NGT controls (P = 0.016).
|
18628523 |
2008 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
SLC30A8 (rs13266634) was the only type 2 diabetes variant associated with higher fasting glucose (0.033 mmol/l [0.01-0.06], P = 0.01).
|
19741166 |
2009 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
When combined, each additional risk allele from CDKAL1-rs9465871, CDKN2A/B-rs10811661, IGF2BP2-rs4402960, and SLC30A8-rs13266634 increased the risk for type 2 diabetes by 1.24-fold (P = 2.85 x 10(-7)) or for combined IFG/type 2 diabetes by 1.21-fold (P = 6.31 x 10(-11)).
|
18633108 |
2008 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Individuals carrying T2D risk alleles of CDKAL1 or SLC30A8 had lower fasting plasma insulin level (rs7756992 P = 0.003) or lower basal insulin secretion (rs13266634 P = 0.0005), respectively, than non-carriers.
|
18210030 |
2008 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Genome-wide association scans for type 2 diabetes (T2D) susceptibility loci revealed and then replicated a highly significant association between the R allele of the R325W variant of SLC30A8 (marker rs13266634) and susceptibility to T2D in Caucasians.
|
19655390 |
2009 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A total of 556 healthy controls and 413 T2DM patients were genotyped for ZnT8 Arg325Trp polymorphism confirming the association of Arg-325 variant with an increased T2DM risk (OR = 1.35 95% C.I: 1.10-1.66; p = 0.0044).
|
30142362 |
2018 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Of European non-diabetic offspring of type 2 diabetes patients, 46% are homozygous carriers of the Arg325Trp polymorphism in ZnT-8, which is known to associate with type 2 diabetes.
|
18324385 |
2008 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Although previous meta-analyses have shown that this association was only found in Asian and European groups, and not in African populations, our analysis revealed the deleterious effect of SLC30A8 rs13266634 on T2DM in an African population when stratified by ethnicity under additive model even with a small number of studies.
|
26832344 |
2016 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We confirm the association of TCF7L2 (rs7903146) and SLC30A8 (rs13266634) with T2D.
|
27310578 |
2016 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
SNPs in other genes such as rs7756992 in CDKAL1, rs10811661 in CDKN2B and rs13266634 in SLC30A8 showed nominal association with type 2 diabetes. rs7756992 in CDKAL1 and rs10811661 in CDKN2B were correlated with impaired pancreatic beta cell function as estimated by the homeostasis model assessment beta index (p = 0.023, p = 0.0083, respectively).
|
17928989 |
2007 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Gene-environment interaction analysis showed a significant interaction between rs13266634</span> in SLC30A8 gene and age on T2DM risk (P<0.0001).
|
24736664 |
2014 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363).
|
18162508 |
2008 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Using MGA, some common gene variants were found to have little (<5%) but significant impact on the heritability of T2D related QTs [KCNJ11 (rs5219), p=0.004]; [IGF2BP2 (rs4402960), p=0.02]; [SLC30A8 (rs13266634), p=0.05]; [CAPN10 (rs2975760), p=0.031]; [FTO (rs8050136), p=0.023]; [FTO (rs9939609), p=0.018] and [SLC30A8 (rs13266634), p=0.05].
|
24993573 |
2014 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The SLC30A8 rs13266634 polymorphism is among the most confirmed genetic markers of T2D in Europeans and East Asians.
|
20138556 |
2010 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
We hypothesised that the risk allele at the type 2 diabetes-associated missense polymorphism rs13266634 (R325W) in SLC30A8 would predict proinsulin levels in individuals at risk of type 2 diabetes and may modulate response to preventive interventions.
|
21779873 |
2011 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
For this reason, the present study looked at the contribution of ENNP1 (rs1044498), IGF2BP2 (rs1470579), KCNJ11 (rs5219), MLXIPL (rs7800944), PPARγ (rs1801282), SLC30A8 (rs13266634) and TCF7L2 (rs7903146) SNPs to the risk of T2DM in Lebanese and Tunisian Arabs.
|
22749234 |
2012 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
After excluding four SNPs due to Hardy-Weinberg disequilibrium, significant associations in age-matched cohorts were found betweenT2DM and the following SNPs: rs9939609 (FTO), rs13266634 (SLC30A8), rs7961581 (TSPAN8/LGR5), and rs1799883 (FABP2).
|
28738793 |
2017 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Meanwhile PPARG-2 Pro12Ala, CDKN2A/2B rs10811661, IGF2BP2 rs4402960, HHEX rs7923837, CDKAL1 rs7754840, EXT2 rs1113132 and SLC30A8 rs13266634 were found to have no significant association with T2D among Arabs.
|
23458876 |
2013 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05).
|
23298195 |
2013 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
Recent genome wide association studies indicated that Arg325Trp polymorphism of Slc30a8 encoding ZnT8 is associated with susceptibility to type 2 diabetes.
|
21099260 |
2011 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A non-synonymous polymorphism (R325W) in its gene is associated with Type-2 diabetes.
|
30710592 |
2019 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
The R325W (rs13266634) nonsynonymous polymorphism in the islet-specific zinc transporter protein gene, SLC30A8, has been reported to be associated with type 2 diabetes and possibly with a defect in insulin secretion.
|
18162509 |
2008 |
|
rs13266634
|
|
|
1.000 |
GeneticVariation |
BEFREE |
A common variant W325R in the C-terminal domain (CTD) increases the risk to develop type 2 diabetes and affects autoantibody specificity in type 1 diabetes.
|
29430817 |
2018 |