|
rs11938093
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We typed three variants, exon1 Cys7Gly (C7G), exon 2 Leu44Phe (L44F), and exon 4 Leu124Met (L124M), in 188 control subjects and 364 subjects with type 2 diabetes.
|
16869959 |
2006 |
|
rs56320257
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We typed three variants, exon1 Cys7Gly (C7G), exon 2 Leu44Phe (L44F), and exon 4 Leu124Met (L124M), in 188 control subjects and 364 subjects with type 2 diabetes.
|
16869959 |
2006 |
|
rs28549760
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We typed three variants, exon1 Cys7Gly (C7G), exon 2 Leu44Phe (L44F), and exon 4 Leu124Met (L124M), in 188 control subjects and 364 subjects with type 2 diabetes.
|
16869959 |
2006 |
|
rs8192678
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We therefore investigated if PPARGC1A expression is altered in islets from patients with type 2 diabetes and whether this expression is influenced by genetic (PPARGC1A Gly482Ser polymorphism) and epigenetic (DNA methylation) factors.
|
18270681 |
2008 |
|
rs4969168
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We therefore examined the association between rs4969168 within SOCS3 and T2DM in three independent study populations; one prospective case-cohort study and two cross-sectional study populations.
|
19052638 |
2008 |
|
rs1801282
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We therefore assessed the associations between the most common variant of the PPAR-gamma, the Pro12Ala (P12A) substitution in the PPAR-gamma 2 gene, with BMI, blood pressure, fasting plasma glucose, HbA1c, total cholesterol, LDL and HDL cholesterol and plasma triglyceride in 183 treatment-naïve patients with type 2 diabetes (T2D).
|
12406034 |
2002 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We therefore assessed the associations between the most common variant of the PPAR-gamma, the Pro12Ala (P12A) substitution in the PPAR-gamma 2 gene, with BMI, blood pressure, fasting plasma glucose, HbA1c, total cholesterol, LDL and HDL cholesterol and plasma triglyceride in 183 treatment-naïve patients with type 2 diabetes (T2D).
|
12406034 |
2002 |
|
rs5743708
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We therefore aimed to investigate the possible role of TLR-2 del -196-174 and Arg753Gln variants in T2DM pathogenesis.
|
30124003 |
2019 |
|
rs2943641
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We then selected the 28 best hits for replication in 7,698 Danish subjects and identified 4 SNPs showing strong association with T2</span>D, one of which (rs2943641, P = 9.3 x 10(-12), OR = 1.19) was located adjacent to the insulin receptor substrate 1 gene (IRS1).
|
19734900 |
2009 |
|
rs12255372
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We tested whether the expression of TCF7L2 splicing forms was associated with single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, located within introns 3 and 4 of the gene and most strongly associated with T2D.
|
19602480 |
2009 |
|
rs7903146
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We tested whether the expression of TCF7L2 splicing forms was associated with single nucleotide polymorphisms (SNPs), rs7903146 and rs12255372, located within introns 3 and 4 of the gene and most strongly associated with T2D.
|
19602480 |
2009 |
|
rs14259
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We tested the PSMD9 T2D risk SNPs IVS3+nt460A>G, IVS3+nt437T>C and E197G for linkage to T2D-diabetic nephropathy in 200 Italians T2D families and show linkage to diabetic nephropathy.
|
21439668 |
2011 |
|
rs765798193
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We tested the PSMD9 T2D risk SNPs IVS3+nt460A>G, IVS3+nt437T>C and E197G for linkage to T2D-diabetic nephropathy in 200 Italians T2D families and show linkage to diabetic nephropathy.
|
21439668 |
2011 |
|
rs7895340
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM.
|
23107111 |
2012 |
|
rs7901695
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM.
|
23107111 |
2012 |
|
rs14259
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We tested in the 200 Italians families for the presence of the linkage of the PSMD9 T2D risk single nucleotide polymorphisms (SNPs) IVS3+nt460 A > G, IVS3+nt437 T > C and E197G A > G with elevated blood pressure/hypertension.
|
21871126 |
2011 |
|
rs765798193
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We tested in the 200 Italians families for the presence of the linkage of the PSMD9 T2D risk single nucleotide polymorphisms (SNPs) IVS3+nt460 A > G, IVS3+nt437 T > C and E197G A > G with elevated blood pressure/hypertension.
|
21871126 |
2011 |
|
rs2943634
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We tested 1) four SNPs previously shown to be associated with IR (rs2972146, rs2943650), T2D (rs2943641) or CAD (rs2943634) and 2) any SNP at 2q36.3-IRS1, for association with subclinical atherosclerosis traits, adjusting for atherosclerosis risk factors.
|
23659870 |
2013 |
|
rs2943641
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We tested 1) four SNPs previously shown to be associated with IR (rs2972146, rs2943650), T2D (rs2943641) or CAD (rs2943634) and 2) any SNP at 2q36.3-IRS1, for association with subclinical atherosclerosis traits, adjusting for atherosclerosis risk factors.
|
23659870 |
2013 |
|
rs1800206
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We suggest that the PPARA L162V polymorphism may have diverse effects on serum lipids and CHD risk depends on the presence of T2DM.
|
23583468 |
2013 |
|
rs1800206
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We subsequently screened a sample of 121 patients newly diagnosed with type 2 diabetes and their age and sex-matched nondiabetic controls, recruited from the Saguenay-Lac-St-Jean region of Northeastern Quebec, for the presence of the L162V mutation by a PCR-RFLP based method.
|
10828087 |
2000 |
|
rs4762
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We studied the relationship of either an insertion-deletion polymorphism in the angiotensin-converting enzyme (ACE) gene and the M235T and T174M variant polymorphisms of the angiotensinogen (AGT) gene in non-insulin-dependent diabetes mellitus (NIDDM) patients and its relationship with cardiovascular complications.
|
9258285 |
1997 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the relationship of either an insertion-deletion polymorphism in the angiotensin-converting enzyme (ACE) gene and the M235T and T174M variant polymorphisms of the angiotensinogen (AGT) gene in non-insulin-dependent diabetes mellitus (NIDDM) patients and its relationship with cardiovascular complications.
|
9258285 |
1997 |
|
rs1267969615
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We studied the relationship of either an insertion-deletion polymorphism in the angiotensin-converting enzyme (ACE) gene and the M235T and T174M variant polymorphisms of the angiotensinogen (AGT) gene in non-insulin-dependent diabetes mellitus (NIDDM) patients and its relationship with cardiovascular complications.
|
9258285 |
1997 |
|
rs4986791
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We studied the prevalence of two common polymorphisms of the TLR4 gene (Asp299Gly and Thr399Ile) in 3 independent study populations: (1.) in a cross-sectional study including 769 patients either with type 1 or type 2 diabetes mellitus, of whom 56 (7.2%) had a history of cerebral ischemia (study 1), (2.) a case-control study (study 2) including 128 consecutive patients with cerebral ischemia, mean age 60 +/- 10.9 years and 139 control subjects, and (3.) a case-control study (study 3) including 171 young adults aged < 50 years with cerebral ischemia and 204 control individuals.
|
15258789 |
2004 |