|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study revealed RAS genes, ACE and AGT-M235T but not AGT-T174M, AGTR1 or REN genotypes, as contributing factors for DN in type 2 diabetes mellitus in Chinese.
|
11776100 |
2000 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study revealed RAS genes, ACE and AGT-M235T but not AGT-T174M, AGTR1 or REN genotypes, as contributing factors for DN in type 2 diabetes mellitus in Chinese.
|
11776100 |
2000 |
|
rs4762
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our study revealed RAS genes, ACE and AGT-M235T but not AGT-T174M, AGTR1 or REN genotypes, as contributing factors for DN in type 2 diabetes mellitus in Chinese.
|
11776100 |
2000 |
|
rs2229569
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We determined the frequency of the LECAM-1 P213S genotype in 102 diabetic patients with diabetic nephropathy, 90 diabetic patients with no evidence of diabetic nephropathy, and 200 healthy control individuals.
|
12200076 |
2003 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Conflicting results on the relationship between M235T polymorphism of angiotensinogen (AGT) gene and diabetic nephropathy are reported in the literature, probably due to the small number of subjects, to different inclusion criteria and the different genotype analysis methods used.
|
12270765 |
2002 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Conflicting results on the relationship between M235T polymorphism of angiotensinogen (AGT) gene and diabetic nephropathy are reported in the literature, probably due to the small number of subjects, to different inclusion criteria and the different genotype analysis methods used.
|
12270765 |
2002 |
|
rs1157043147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that TGF-beta T869C (Leu 10Pro) gene polymorphism is associated with DMN in Chinese.
|
12675860 |
2003 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Using both a large case-control and a follow-up study, we found no evidence that the C677T MTHFR polymorphism has a significant role in the development of diabetic nephropathy in type 1 diabetes.
|
12776270 |
2003 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The methylenetetrahydrofolate reductase 677 C/T genotypes were determined in 174 type 2 diabetic patients: 80 with and 94 without renal failure due to diabetic nephropathy.
|
12784186 |
2003 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy.
|
12897091 |
2003 |
|
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy.
|
12897091 |
2003 |
|
rs1267969615
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The impact of polymorphisms in the genes coding for angiotensinogen (M235T), ACE (ID), and angiotensin II type 1 receptor (A(1166)-->C) on decline in GFR and doubling of s-creatinine or development of ESRD in patients with type 1 diabetes and diabetic nephropathy (DN) was tested.
|
14569094 |
2003 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The impact of polymorphisms in the genes coding for angiotensinogen (M235T), ACE (ID), and angiotensin II type 1 receptor (A(1166)-->C) on decline in GFR and doubling of s-creatinine or development of ESRD in patients with type 1 diabetes and diabetic nephropathy (DN) was tested.
|
14569094 |
2003 |
|
rs11643718
|
|
|
0.070 |
GeneticVariation |
BEFREE |
The results implicated that substitution of Arg913 to Gln in the SLC12A3 gene might reduce the risk to develop diabetic nephropathy and suggested that the gene product might be a potential target for the prevention or treatment of this disease.
|
14578305 |
2003 |
|
rs4986790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In type 2 diabetic patients, however, heterozygote carriers of the Asp299Gly and Thr399Ile genotypes had a significantly reduced prevalence of diabetic neuropathy (odds ratio 0.35 [95% CI 0.19-0.61]; P = 0.0002); no association with diabetic nephropathy was found.
|
14693986 |
2004 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In type 2 diabetic patients, however, heterozygote carriers of the Asp299Gly and Thr399Ile genotypes had a significantly reduced prevalence of diabetic neuropathy (odds ratio 0.35 [95% CI 0.19-0.61]; P = 0.0002); no association with diabetic nephropathy was found.
|
14693986 |
2004 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that the C677T mutation in the MTHFR gene predisposes type 2 diabetes patients to the development of diabetic nephropathy.
|
14737040 |
2004 |
|
rs16139
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We conclude that the Leu7Pro polymorphism may contribute to the genetic susceptibility to diabetic nephropathy and CHD in type 1 diabetic patients, possibly by influencing glycemic control and triglycerides.
|
14747236 |
2004 |
|
rs6280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether two previously known (-707 G/C, Ser9Gly) and one novel (Ala17Ala) polymorphism in the dopamine D3 receptor gene and/or their haplotypes are associated with blood pressure, diabetic nephropathy or renal variables in the study subjects.
|
15004255 |
2004 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T gene polymorphism associated with a predisposition to increased plasma homocysteine levels may represent a genetic risk factor for diabetic nephropathy in Chinese type 2 diabetic patients.
|
15126006 |
2004 |
|
rs1799983
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Relations between eNOS Glu298Asp polymorphism and progression of diabetic nephropathy.
|
15331206 |
2004 |
|
rs1177506410
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Relations between eNOS Glu298Asp polymorphism and progression of diabetic nephropathy.
|
15331206 |
2004 |
|
rs1275805226
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Relations between eNOS Glu298Asp polymorphism and progression of diabetic nephropathy.
|
15331206 |
2004 |
|
rs2228146
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variant V385I was unique to African-Americans and was significantly associated with diabetes and diabetic nephropathy (P < 0.05).
|
15562008 |
2005 |
|
rs11643718
|
|
|
0.070 |
GeneticVariation |
BEFREE |
We have shown previously that the SLC12A3 +78G/A polymorphism in exon 23 (Arg913Gln) was a new candidate for conferring susceptibility to diabetic nephropathy.
|
15915338 |
2005 |