Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs671
rs671
ALDH2
0.880 GeneticVariation BEFREE Its encoding gene ALDH2 has a functional polymorphism: ALDH2 Glu487LYS: An association between this polymorphism and esophageal cancer among alcoholics has been reported. 11375898

2001
dbSNP: rs1229984
rs1229984
ADH1B
0.840 GeneticVariation BEFREE Our results suggested that ADH1B gene Arg47His variant was associated with the decreased esophageal cancer risk. 27450204

2016
dbSNP: rs1229984
rs1229984
ADH1B
0.840 GeneticVariation BEFREE The functional polymorphisms ADH1B rs1229984 may contribute to susceptibility to esophageal cancer. 24093763

2014
dbSNP: rs1229984
rs1229984
ADH1B
0.840 GeneticVariation BEFREE In conclusion, our findings indicated that ADH1B (rs1229984) was associated with EC independent of alcohol drinking and tobacco smoking status and alcohol drinking interacted with ALDH2 (rs671) on EC susceptibility in this high-risk Chinese population. 22930414

2013
dbSNP: rs1229984
rs1229984
ADH1B
0.840 GeneticVariation GWASDB Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. 20833657

2010
dbSNP: rs1229984
rs1229984
ADH1B
0.840 GeneticVariation BEFREE ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis. 21048924

2010
dbSNP: rs1229984
rs1229984
ADH1B
G 0.840 GeneticVariation GWASCAT Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. 19698717

2009
dbSNP: rs3765524
rs3765524
PLCE1
0.820 GeneticVariation BEFREE Results showed that the minor alleles of rs3765524, rs2274223, and rs10509670 were associated with increased risk of EC and GC. 30931333

2019
dbSNP: rs3765524
rs3765524
PLCE1
0.820 GeneticVariation BEFREE Phospholipase C epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) polymorphisms and esophageal cancer risk in the Kashmir Valley. 24935391

2014
dbSNP: rs3765524
rs3765524
PLCE1
0.820 GeneticVariation GWASDB Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. 22323360

2012
dbSNP: rs3765524
rs3765524
PLCE1
T 0.820 GeneticVariation GWASDB A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. 20729852

2010
dbSNP: rs3765524
rs3765524
PLCE1
T 0.820 GeneticVariation GWASCAT A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. 20729852

2010
dbSNP: rs738722
rs738722
CHEK2
0.810 GeneticVariation BEFREE The CT allele of SNP rs738722 and the GC allele of SNP rs2236142 might be a protective factor of the risk for lymph node metastasis of esophageal cancer. 22201027

2012
dbSNP: rs738722
rs738722
CHEK2
T 0.810 GeneticVariation GWASCAT A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. 20729852

2010
dbSNP: rs738722
rs738722
CHEK2
T 0.810 GeneticVariation GWASDB A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. 20729852

2010
dbSNP: rs1042026
rs1042026
ADH1B
0.800 GeneticVariation GWASCAT Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs1042026
rs1042026
ADH1B
0.800 GeneticVariation GWASDB Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs17450420
rs17450420 		0.800 GeneticVariation GWASDB Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs17450420
rs17450420 		0.800 GeneticVariation GWASCAT Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs17761864
rs17761864
SMG6
A 0.800 GeneticVariation GWASCAT Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs17761864
rs17761864
SMG6
A 0.800 GeneticVariation GWASDB Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs2239612
rs2239612
ST6GAL1
T 0.800 GeneticVariation GWASDB Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs2239612
rs2239612
ST6GAL1
T 0.800 GeneticVariation GWASCAT Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs2239815
rs2239815
XBP1
T 0.800 GeneticVariation GWASCAT Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012
dbSNP: rs2239815
rs2239815
XBP1
T 0.800 GeneticVariation GWASDB Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. 22960999

2012