rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue.
|
29885788 |
2018 |
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness.
|
22672924 |
2012 |
rs16944
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively.
|
21496483 |
2011 |
rs16944
|
|
|
0.020 |
GeneticVariation |
BEFREE |
IL1B-511 (rs16944) genotype did not significantly predict changes in fatigue (p values >0.46).
|
22475653 |
2012 |
rs1800562
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Male C282Y homozygotes with a serum ferritin level of 1000 mug per liter or more were more likely to report fatigue, use of arthritis medicine, and a history of liver disease than were men who had the wild-type gene.
|
18199861 |
2008 |
rs1800562
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In Northern-European ancestry populations, HFE gene C282Y mutations are relatively common (0.3%-0.6% rare homozygote prevalence) and associated with excessive iron absorption, fatigue, diabetes, arthritis, and liver disease, especially in men.
|
30657865 |
2019 |
rs1800629
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this study, we sought to determine whether a functional genetic variation in a prominent proinflammatory cytokine, tumor necrosis factor-alpha (TNFA-308G>A [rs1800629] promoter polymorphism) was associated with overall ratings of sleep disturbance and fatigue as well as with the trajectories of these symptoms.
|
19419979 |
2009 |
rs1800629
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients with the TNFA-308 (rs1800629) G/A genotype showed greater increases in fatigue severity than the G/G genotype (p = 0.02).
|
22475653 |
2012 |
rs1800795
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients with the IL6-174 (rs1800795) G/C or C/C genotype displayed greater increases in fatigue intrusiveness, frequency, and duration than the G/G genotype (p values ≤ 0.05), although inclusion of age, race, and baseline depressive symptomatology in the model attenuated these relationships (p values ≤ 0.09).
|
22475653 |
2012 |
rs1800795
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively.
|
21496483 |
2011 |
rs1042718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue.
|
27720787 |
2017 |
rs1082214
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We obtained supported evidence for involvement of TIMELESS in sleeping problems in an independent set of control individuals with seasonal changes in mood, sleep duration, energy level and social activity in females (P = 0.036, = 0.123 for rs1082214) and with early morning awakening or fatigue in males (P = 0.038 and P = 0.0016, respectively, for rs1082214).
|
20174623 |
2010 |
rs11214105
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 5' UTR polymorphism (rs11214105) in IL18 also associated with physical fatigue, body pain and score for CFS case defining symptoms.
|
26116897 |
2015 |
rs1212171
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype at the NTRK2 SNP rs1212171 was associated with both sleep disturbance and fatigue.
|
28205449 |
2017 |
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Investigation of MTHFR C677T gene polymorphism, biochemical and clinical parameters in Turkish migraine patients: association with allodynia and fatigue.
|
23975093 |
2013 |
rs121912438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
If activity-dependent conversion of motor units to more fatigue resistant types increased their resilience and hence survival, we hypothesized that an experimental increase in motor unit activity in the hindlimb muscles of the SOD1(G93A) transgenic mouse should "save" those motor units that are normally lost in the first 90 days of age.
|
19879358 |
2010 |
rs121913507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six other patients reported symptomatic improvement, including two with D816V KIT mutation-positive SM (one reported improvement in diarrhea and the other in fatigue).Other patients had no benefit.Imatinib was relatively well tolerated.
|
19193436 |
2009 |
rs121913682
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six other patients reported symptomatic improvement, including two with D816V KIT mutation-positive SM (one reported improvement in diarrhea and the other in fatigue).Other patients had no benefit.Imatinib was relatively well tolerated.
|
19193436 |
2009 |
rs1289543302
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue.
|
29885788 |
2018 |
rs17841327
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue.
|
27720787 |
2017 |
rs1991517
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The modest effect of the TSHR-Asp727Glu polymorphism on fatigue in DTC patients should be confirmed in other cohorts.
|
22989469 |
2012 |
rs199682734
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other genetic associations were also observed in men but not women, such as greater 'feel effects' and anger, and reduced fatigue, in the dopamine D2 receptor (DRD2 C957T single nucleotide polymorphism) TT versus CT or CC genotypes.
|
18690117 |
2008 |
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness.
|
22672924 |
2012 |
rs2228145
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively.
|
21496483 |
2011 |
rs224222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratification analysis according to clinical features for this disease reveals that morning fatigue and irritable bowel syndrome had associations with R202Q polymorphism (p=0.022 and p=0.031 respectively).
|
23010357 |
2012 |