Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1045642
rs1045642
0.020 GeneticVariation BEFREE The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue. 29885788

2018

dbSNP: rs1045642
rs1045642
0.020 GeneticVariation BEFREE i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness. 22672924

2012

dbSNP: rs16944
rs16944
0.020 GeneticVariation BEFREE The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively. 21496483

2011

dbSNP: rs16944
rs16944
0.020 GeneticVariation BEFREE IL1B-511 (rs16944) genotype did not significantly predict changes in fatigue (p values >0.46). 22475653

2012

dbSNP: rs1800562
rs1800562
0.020 GeneticVariation BEFREE Male C282Y homozygotes with a serum ferritin level of 1000 mug per liter or more were more likely to report fatigue, use of arthritis medicine, and a history of liver disease than were men who had the wild-type gene. 18199861

2008

dbSNP: rs1800562
rs1800562
0.020 GeneticVariation BEFREE In Northern-European ancestry populations, HFE gene C282Y mutations are relatively common (0.3%-0.6% rare homozygote prevalence) and associated with excessive iron absorption, fatigue, diabetes, arthritis, and liver disease, especially in men. 30657865

2019

dbSNP: rs1800629
rs1800629
TNF
0.020 GeneticVariation BEFREE In this study, we sought to determine whether a functional genetic variation in a prominent proinflammatory cytokine, tumor necrosis factor-alpha (TNFA-308G>A [rs1800629] promoter polymorphism) was associated with overall ratings of sleep disturbance and fatigue as well as with the trajectories of these symptoms. 19419979

2009

dbSNP: rs1800629
rs1800629
TNF
0.020 GeneticVariation BEFREE Patients with the TNFA-308 (rs1800629) G/A genotype showed greater increases in fatigue severity than the G/G genotype (p = 0.02). 22475653

2012

dbSNP: rs1800795
rs1800795
0.020 GeneticVariation BEFREE Patients with the IL6-174 (rs1800795) G/C or C/C genotype displayed greater increases in fatigue intrusiveness, frequency, and duration than the G/G genotype (p values ≤ 0.05), although inclusion of age, race, and baseline depressive symptomatology in the model attenuated these relationships (p values ≤ 0.09). 22475653

2012

dbSNP: rs1800795
rs1800795
0.020 GeneticVariation BEFREE The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively. 21496483

2011

dbSNP: rs1042718
rs1042718
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017

dbSNP: rs1082214
rs1082214
MIP
0.010 GeneticVariation BEFREE We obtained supported evidence for involvement of TIMELESS in sleeping problems in an independent set of control individuals with seasonal changes in mood, sleep duration, energy level and social activity in females (P = 0.036, = 0.123 for rs1082214) and with early morning awakening or fatigue in males (P = 0.038 and P = 0.0016, respectively, for rs1082214). 20174623

2010

dbSNP: rs11214105
rs11214105
0.010 GeneticVariation BEFREE A 5' UTR polymorphism (rs11214105) in IL18 also associated with physical fatigue, body pain and score for CFS case defining symptoms. 26116897

2015

dbSNP: rs1212171
rs1212171
0.010 GeneticVariation BEFREE Genotype at the NTRK2 SNP rs1212171 was associated with both sleep disturbance and fatigue. 28205449

2017

dbSNP: rs1217691063
rs1217691063
0.010 GeneticVariation BEFREE Investigation of MTHFR C677T gene polymorphism, biochemical and clinical parameters in Turkish migraine patients: association with allodynia and fatigue. 23975093

2013

dbSNP: rs121912438
rs121912438
0.010 GeneticVariation BEFREE If activity-dependent conversion of motor units to more fatigue resistant types increased their resilience and hence survival, we hypothesized that an experimental increase in motor unit activity in the hindlimb muscles of the SOD1(G93A) transgenic mouse should "save" those motor units that are normally lost in the first 90 days of age. 19879358

2010

dbSNP: rs121913507
rs121913507
KIT
0.010 GeneticVariation BEFREE Six other patients reported symptomatic improvement, including two with D816V KIT mutation-positive SM (one reported improvement in diarrhea and the other in fatigue).Other patients had no benefit.Imatinib was relatively well tolerated. 19193436

2009

dbSNP: rs121913682
rs121913682
KIT
0.010 GeneticVariation BEFREE Six other patients reported symptomatic improvement, including two with D816V KIT mutation-positive SM (one reported improvement in diarrhea and the other in fatigue).Other patients had no benefit.Imatinib was relatively well tolerated. 19193436

2009

dbSNP: rs1289543302
rs1289543302
0.010 GeneticVariation BEFREE The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue. 29885788

2018

dbSNP: rs17841327
rs17841327
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017

dbSNP: rs1991517
rs1991517
0.010 GeneticVariation BEFREE The modest effect of the TSHR-Asp727Glu polymorphism on fatigue in DTC patients should be confirmed in other cohorts. 22989469

2012

dbSNP: rs199682734
rs199682734
0.010 GeneticVariation BEFREE Other genetic associations were also observed in men but not women, such as greater 'feel effects' and anger, and reduced fatigue, in the dopamine D2 receptor (DRD2 C957T single nucleotide polymorphism) TT versus CT or CC genotypes. 18690117

2008

dbSNP: rs2032582
rs2032582
0.010 GeneticVariation BEFREE i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness. 22672924

2012

dbSNP: rs2228145
rs2228145
0.010 GeneticVariation BEFREE The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively. 21496483

2011

dbSNP: rs224222
rs224222
0.010 GeneticVariation BEFREE Stratification analysis according to clinical features for this disease reveals that morning fatigue and irritable bowel syndrome had associations with R202Q polymorphism (p=0.022 and p=0.031 respectively). 23010357

2012