Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs387907170
rs387907170
ETFDH
0.010 GeneticVariation BEFREE Siblings with the common myopathic ETFDH c.1130T>C mutation presented with a new phenotype dominated by chronic fatigue without apparent myopathy. 31331668

2019
dbSNP: rs4570625
rs4570625
TPH2
0.010 GeneticVariation BEFREE Only one SNP, TPH2 rs4570625, was significantly associated with fatigue ( p = .005). 30309244

2019
dbSNP: rs1289543302
rs1289543302
ABCB1
0.010 GeneticVariation BEFREE The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue. 29885788

2018
dbSNP: rs25531
rs25531
SLC6A4 ; LOC105371720
0.010 GeneticVariation BEFREE Susceptibility and severity of cancer-related fatigue in colorectal cancer patients is associated with SLC6A4 gene single nucleotide polymorphism rs25531 A>G genotype. 29551185

2018
dbSNP: rs3740071
rs3740071
ABCC2
0.010 GeneticVariation BEFREE The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue. 29885788

2018
dbSNP: rs1042718
rs1042718
ADRB2
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017
dbSNP: rs1212171
rs1212171
NTRK2
0.010 GeneticVariation BEFREE Genotype at the NTRK2 SNP rs1212171 was associated with both sleep disturbance and fatigue. 28205449

2017
dbSNP: rs17841327
rs17841327
SLC6A2
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017
dbSNP: rs2293052
rs2293052
NOS1
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017
dbSNP: rs34778348
rs34778348
LRRK2 ; LOC105369736
0.010 GeneticVariation BEFREE Overall, we found that carriers of the G2385R variant were more prone to fatigue than non-carriers in PD patients. 28941828

2017
dbSNP: rs3783642
rs3783642
GCH1
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017
dbSNP: rs4646437
rs4646437
CYP3A4
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017
dbSNP: rs9332377
rs9332377
ARVCF ; COMT
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017
dbSNP: rs949060
rs949060 		0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017
dbSNP: rs9658498
rs9658498
NOS1
0.010 GeneticVariation BEFREE Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue. 27720787

2017
dbSNP: rs11214105
rs11214105
TEX12 ; LOC107987164
0.010 GeneticVariation BEFREE A 5' UTR polymorphism (rs11214105) in IL18 also associated with physical fatigue, body pain and score for CFS case defining symptoms. 26116897

2015
dbSNP: rs4251961
rs4251961
IL1RN
0.010 GeneticVariation BEFREE The C allele of the rs4251961 single nucleotide polymorphism (SNP) in IL1RN was associated with self-reported fatigue (P = .03), whereas the cosegregating polymorphisms in TLR4 were associated with lower levels of fatigue (P= .04). 25542762

2015
dbSNP: rs1217691063
rs1217691063
MTHFR
0.010 GeneticVariation BEFREE Investigation of MTHFR C677T gene polymorphism, biochemical and clinical parameters in Turkish migraine patients: association with allodynia and fatigue. 23975093

2013
dbSNP: rs3087243
rs3087243
CTLA4
0.010 GeneticVariation BEFREE Besides, patients carrying A allele of rs3087243 had significantly lower score of fatigue domain than those carrying G allele (2.5 ± 0.8 vs 3.9 ± 1.3, P < 0.001). 23432218

2013
dbSNP: rs1991517
rs1991517
TSHR ; LOC101928462
0.010 GeneticVariation BEFREE The modest effect of the TSHR-Asp727Glu polymorphism on fatigue in DTC patients should be confirmed in other cohorts. 22989469

2012
dbSNP: rs2032582
rs2032582
ABCB1
0.010 GeneticVariation BEFREE i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness. 22672924

2012
dbSNP: rs224222
rs224222
MEFV
0.010 GeneticVariation BEFREE Stratification analysis according to clinical features for this disease reveals that morning fatigue and irritable bowel syndrome had associations with R202Q polymorphism (p=0.022 and p=0.031 respectively). 23010357

2012
dbSNP: rs2287396
rs2287396
GSTZ1
0.010 GeneticVariation BEFREE Two SNPs (rs2287396 [GSTZ1] and rs9524885 [ABCC4]) from glutathione metabolic pathway were associated with fatigue in unadjusted analysis. 22454423

2012
dbSNP: rs4680
rs4680
COMT ; MIR4761
0.010 GeneticVariation BEFREE Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors. 21898113

2012