|
rs949060
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue.
|
27720787 |
2017 |
|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue.
|
29885788 |
2018 |
|
rs1045642
|
|
|
0.020 |
GeneticVariation |
BEFREE |
i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness.
|
22672924 |
2012 |
|
rs1289543302
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue.
|
29885788 |
2018 |
|
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
i) In the experimental mouse model, we observed that brain concentrations of cabergoline were tenfold higher in the mutant mice compared with their wild-type littermates, implying that cabergoline is indeed a substrate of the transporter P-gp at the blood-brain barrier level. ii) In the human study, we observed significant negative associations under cabergoline for the C-carriers and heterozygous CT individuals of SNP rs1045642 with two central side effects (frequency of fatigue and sleep disorders) and for the G-carriers of SNP rs2032582 with the enhancement of dizziness.
|
22672924 |
2012 |
|
rs3740071
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant allele of ABCB1 3435C>T polymorphism could be a potential predictive biomarker of docetaxel-induced rash, and homozygous wild-type ABCB1 2677G>A/T might predict for a greater risk of fatigue.
|
29885788 |
2018 |
|
rs9524885
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs2287396 [GSTZ1] and rs9524885 [ABCC4]) from glutathione metabolic pathway were associated with fatigue in unadjusted analysis.
|
22454423 |
2012 |
|
rs574584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Mexican patients with the rs574584 GG genotype presented the highest FIQ score compared with Mexican patients with other genotypes (P = 0.01), and in Mexicans SNP rs574584 was associated with FIQ morning stiffness (P = 0.04) and with FIQ tiredness upon awakening (P = 0.02).
|
19565482 |
2009 |
|
rs1042718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue.
|
27720787 |
2017 |
|
rs151344517
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
Missense mutations in the AFG3L2 proteolytic domain account for ∼1.5% of European autosomal dominant cerebellar ataxias.
|
20725928 |
2010 |
|
rs267606640
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Even heterozygous p.W1327X mutation carriers may present with mild non-progressive neuromuscular symptoms, such as exercise-induced myalgia and fatigue.
|
18924225 |
2008 |
|
rs864321670
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs869312697
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs9332377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue.
|
27720787 |
2017 |
|
rs6265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue.
|
27720787 |
2017 |
|
rs1554317002
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1057523354
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1057518925
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors.
|
21898113 |
2012 |
|
rs2794521
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associations between fatigue and SNPs in inflammation-related genes; IL1β (rs16944), IL6 (rs1800795), IL6receptor (rs4129267, rs4845617, rs2228145), CRP (rs2794521, rs3091244) were investigated, together with the relations between SNPs in IL6R,IL1β and CRP genes and mRNA blood expression levels of IL6R and IL1β and serum hsCRP-levels, respectively.
|
21496483 |
2011 |
|
rs3091244
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a large cohort of BCSs the investigated SNPs in inflammation-related genes were not associated with fatigue, though subset analyses indicated an association between the CRP SNP (rs3091244) and serum hsCRP.
|
21496483 |
2011 |
|
rs3087243
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Besides, patients carrying A allele of rs3087243 had significantly lower score of fatigue domain than those carrying G allele (2.5 ± 0.8 vs 3.9 ± 1.3, P < 0.001).
|
23432218 |
2013 |
|
rs4646437
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eleven single-nucleotide polymorphisms or haplotypes (i.e., ADRB2 rs1042718, BDNF rs6265, COMT rs9332377, CYP3A4 rs4646437, GALR1 rs949060, GCH1 rs3783642, NOS1 rs9658498, NOS1 rs2293052, NPY1R Haplotype A04, SLC6A2 rs17841327, and 5HTTLPR + rs25531 in SLC6A4) were associated with latent class membership for fatigue.
|
27720787 |
2017 |
|
rs6277
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other genetic associations were also observed in men but not women, such as greater 'feel effects' and anger, and reduced fatigue, in the dopamine D2 receptor (DRD2 C957T single nucleotide polymorphism) TT versus CT or CC genotypes.
|
18690117 |
2008 |
|
rs387907170
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Siblings with the common myopathic ETFDH c.1130T>C mutation presented with a new phenotype dominated by chronic fatigue without apparent myopathy.
|
31331668 |
2019 |