|
rs10189761
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs10189761 and rs737337 were identified, for the first time, as independent predictors of major clinical outcomes in patients with HF.
|
31209632 |
2019 |
|
rs12567209
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele of rs12567209 in NOS1AP may serve as an independent predictor of all-cause death and SCD in patients with CHF, it is also associated with prolonged QTc interval in the Chinese Han population.
|
24418727 |
2014 |
|
rs28714259
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs28714259 represents a validated SNP that is associated with anthracycline-induced CHF in three independent, phase III adjuvant breast cancer clinical trials.
|
27993963 |
2017 |
|
rs499818
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Six associations yielded p < 10(-5).The lowest p-values for each CVD trait were as follows: major CVD, rs499818, p = 6.6 x 10(-6); major CHD, rs2549513, p = 9.7 x 10(-6); AF, rs958546, p = 4.8 x 10(-6); HF: rs740363, p = 8.8 x 10(-6).
|
17903304 |
2007 |
|
rs9351814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018).
|
31209632 |
2019 |
|
rs9885413
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified and replicated an association for a genetic variant on chromosome 5q22 with 36% increased risk of death in subjects with heart failure (rs9885413, P = 2.7x10-9).
|
27149122 |
2016 |
|
rs8187710
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate analysis revealed that the odds of CHF was higher in females [Odds Ratio (OR) = 2·9, P < 0·01], individuals with pre-HCT chest radiation (OR = 4·7, P = 0·05), hypertension (OR = 2·9, P = 0·01), and with variants of genes coding for the NAD(P)H-oxidase subunit RAC2 (rs13058338, 7508T→A; OR = 2·8, P < 0·01), HFE (rs1799945, 63C→G; OR = 2·5, P = 0·05) or the doxorubicin efflux transporter ABCC2 (rs8187710, 1515G→A; OR = 4·3, P < 0·01).
|
23927520 |
2013 |
|
rs1344172059
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs141322087
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The DD allele frequency is lower in Chinese, but the M235T variant of the angiotensinogen gene is more common in Chinese than whites; it is not known to what extent polymorphisms of the renin-angiotensin system affect clinical status or prognosis in Chinese patients with heart failure.
|
10097225 |
1999 |
|
rs1799752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated nuclear factor kappa B {NFkB, rs28362491 [-94ins/delATTG (W/D)]} and angiotensin converting enzyme {ACE; rs1799752 [Ins(I)/Del(D)]} gene polymorphisms and their correlation with thyroid function in patients with heart failure (HF).
|
23543433 |
2014 |
|
rs1815739
|
|
|
0.010 |
GeneticVariation |
BEFREE |
R577X polymorphism in the ACTN3 gene was independently associated with worse survival in patients with chronic heart failure.
|
25059829 |
2014 |
|
rs452159
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, rs452159 polymorphism in ADA gene was significantly associated with susceptibility to CHF under the dominant model (p = 0.013, OR = 1.537, 95% CI = 1.10-2.16), after adjustment for age, sex, and traditional cardiovascular risk factors.
|
25170811 |
2014 |
|
rs4822489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings of this study suggest that rs4822489 may contribute to the severity of CHF in the northern Chinese.
|
25629231 |
2015 |
|
rs1544223
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, the rs1544223 was significantly associated with CHF risk under the dominant model (<i>P</i> = 0.046, OR = 1.662, 95% CI = 1.009-2.738).But it did not affect disease severity.
|
29955603 |
2018 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated whether a predefined combination of the Arg389Gly polymorphism in the adrenergic β(1) -receptor gene (ADRB1) and the Gln27Glu polymorphism in the adrenergic β(2) -receptor gene (ADRB2) could predict survival in carvedilol- and metoprolol-treated chronic heart failure (HF) patients.
|
21395649 |
2011 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study sought to investigate whether ADRB1 Arg389Gly (rs1801253), GNAS -1211 G/A (rs6123837) and GNAS 2291 C/T (rs6026584) variants are associated with left ventricular function and exercise tolerance in heart failure patients.
|
23065660 |
2013 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We tested the hypothesis that polymorphisms at codons 389 (Arg389Gly) and 49 (Ser49Gly) of the beta(1)-adrenergic receptor would be associated with differences in initial tolerability of beta-blocker therapy in patients with heart failure.
|
15735607 |
2005 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Bucindolol is a non-selective beta-blocker with mild vasodilator activity previously found to have accentuated antiarrhythmic effects and increased efficacy for preventing heart failure events in patients homozygous for the major allele of the ADRB1 Arg389Gly polymorphism (ADRB1 Arg389Arg genotype).
|
29754666 |
2018 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Arg389Gly polymorphism has a major impact on the heart-rate response to carvedilol (but not bisoprolol) in patients with heart failure plus atrial fibrillation.
|
22617224 |
2012 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) within the β(1)- (Ser49Gly, Arg389Gly) and β(2)-adrenoceptor (Arg16Gly, Gln27Glu, Thr164Ile) have been associated with alterations in adrenoceptor (AR) function sensitivity in vitro and in vivo and possibly contribute to HF progression.
|
20803192 |
2010 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We used uniform methodology to investigate BB dose-ADRB1 Arg389Gly polymorphism interaction with major clinical end points in BEST/bucindolol and HF-ACTION/other BB databases.
|
30354340 |
2018 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined whether the Arg389Gly polymorphism in ADRβ1 interacts with the dose requirements of beta-blockers in patients with systolic HF.
|
23115322 |
2013 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of this study was to determine whether ADRB1 Ser49Gly and Arg389Gly are associated with recovery of left ventricular ejection fraction (LVEF) in patients with heart failure.
|
30756358 |
2019 |
|
rs1801253
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the β1 adrenergic receptor gene Arg389Gly polymorphism might not be associated with heart failure risk.
|
26125791 |
2015 |