|
rs3197999
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Importantly, we discovered that serum protein levels of MST1 (Macrophage Stimulating 1) were regulated by SNP rs3197999 (p = 5.96E-10, FDR<5%), an accepted GWAS locus for IBD.
|
28129359 |
2017 |
|
rs3197999
|
|
|
0.850 |
GeneticVariation |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
rs3197999
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Genome-wide association studies have identified and repeatedly confirmed the association of rs3197999 in MST1 with inflammatory bowel disease (IBD).
|
26355565 |
2015 |
|
rs3197999
|
|
A |
0.850 |
GeneticVariation |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
rs3197999
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Therefore, the gain of function observed with rs3197999 in MST1 might provide a cellular mechanism for the consistent association of this polymorphism with an increased risk for IBD and PSC.
|
22237417 |
2012 |
|
rs3197999
|
|
A |
0.850 |
GeneticVariation |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
rs3197999
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The polymorphisms rs9858542 (BSN) and rs3197999 (MST1), on 3p21 locus, have been found associated with susceptibility to IBD.
|
20024904 |
2010 |
|
rs3197999
|
|
|
0.850 |
GeneticVariation |
BEFREE |
R689C is predicted to interfere with MSP binding to its receptor, suggesting a role for this gene in the pathogenesis of IBD.
|
19079170 |
2008 |
|
rs10500264
|
|
|
0.820 |
GeneticVariation |
BEFREE |
One SNP (rs4986791 in the TLR-4 locus) and 2 SNPs (rs6785049 in the Pregnane-x-receptor gene and rs10500264 in the SLCA10 gene) were associated with a change in albumin and hemoglobin over time respectively in our IBD cohort.
|
30423580 |
2019 |
|
rs2076756
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The sibling with pouchitis inherited the IBD-associated risk alleles for NOD2 (rs17221417 and rs2076756) from his healthy father.
|
28633443 |
2017 |
|
rs6871626
|
|
|
0.820 |
GeneticVariation |
BEFREE |
IL12B rs6871626 did not show an association with IBD-TA compared with that with TA without IBD.
|
28449344 |
2017 |
|
rs6871626
|
|
A |
0.820 |
GeneticVariation |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
rs6871626
|
|
A |
0.820 |
GeneticVariation |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
|
rs6871626
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10(-19); odds ratio [OR] = 1.30) and rs6871626 on 5q33.3 (p = 3.95 × 10(-18); OR = 0.75), implicating IL18RAP/IL18R1 and IL12B as susceptibility genes for leprosy.
|
23103228 |
2012 |
|
rs2076756
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The aims were to analyze two novel NOD2 variants (rs2066843 and rs2076756) in a large cohort of patients with inflammatory bowel disease and to elucidate phenotypic consequences.
|
21209938 |
2010 |
|
rs10500264
|
|
|
0.820 |
GeneticVariation |
GWASDB |
We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)).
|
19915574 |
2009 |
|
rs10500264
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)).
|
19915574 |
2009 |
|
rs10500264
|
|
|
0.820 |
GeneticVariation |
GWASCAT |
We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)).
|
19915574 |
2009 |
|
rs2076756
|
|
|
0.820 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
rs2076756
|
|
|
0.820 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
|
rs7134599
|
|
|
0.810 |
GeneticVariation |
BEFREE |
The significance of these results is amplified by studies suggesting that a single nucleotide polymorphism in IFNG-AS1, rs7134599, was associated with both subtypes of IBD patients independently of race.
|
31545920 |
2020 |
|
rs8005161
|
|
|
0.810 |
GeneticVariation |
BEFREE |
The T allele of rs8005161 might confer a more severe disease course in IBD patients.
|
30616622 |
2019 |
|
rs1250550
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
rs2382817
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |
|
rs3024505
|
|
|
0.810 |
GeneticVariation |
GWASCAT |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.
|
28067908 |
2017 |