Gene: FLT3 ×
Source: INFERRED ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519766
rs1057519766
FLT3
T 0.720 GeneticVariation CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500

2014
dbSNP: rs1057519766
rs1057519766
FLT3
C 0.720 GeneticVariation CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500

2014
dbSNP: rs1057519766
rs1057519766
FLT3
C 0.720 GeneticVariation CLINVAR Gene expression analysis of AML patients with CBFB/MYH11 rearrangement and FLT3 N676K mutation showed a trend toward a specific expression profile. 23878140

2013
dbSNP: rs1057519766
rs1057519766
FLT3
T 0.720 GeneticVariation CLINVAR Gene expression analysis of AML patients with CBFB/MYH11 rearrangement and FLT3 N676K mutation showed a trend toward a specific expression profile. 23878140

2013
dbSNP: rs1057519764
rs1057519764
FLT3
C 0.710 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs1057519764
rs1057519764
FLT3
T 0.710 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs1057520026
rs1057520026
FLT3
G 0.710 GeneticVariation CLINVAR The other novel mutation, FLT3 K663Q, is the first AML-associated gain-of-function mutation located outside the JM and AL domains. 16990784

2006
dbSNP: rs376588714
rs376588714
FLT3
C 0.710 GeneticVariation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs376588714
rs376588714
FLT3
C 0.710 GeneticVariation CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500

2014
dbSNP: rs376588714
rs376588714
FLT3
C 0.710 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs1057519726
rs1057519726
FLT3
C 0.700 GeneticVariation CLINVAR Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations. 16573742

2006
dbSNP: rs1057519726
rs1057519726
FLT3
A 0.700 GeneticVariation CLINVAR Novel observation of three FLT3 codons mutated in tandem in an elderly acute myeloid leukaemia patient. 16371029

2006
dbSNP: rs1057519762
rs1057519762
FLT3
G 0.700 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs1057519762
rs1057519762
FLT3
G 0.700 GeneticVariation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs1057519762
rs1057519762
FLT3
G 0.700 GeneticVariation CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500

2014
dbSNP: rs1057519763
rs1057519763
FLT3
AA 0.700 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs1057519765
rs1057519765
FLT3
A 0.700 GeneticVariation CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500

2014
dbSNP: rs1057519765
rs1057519765
FLT3
A 0.700 GeneticVariation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs1057519765
rs1057519765
FLT3
A 0.700 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs1057519767
rs1057519767
FLT3
C 0.700 GeneticVariation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs1057519767
rs1057519767
FLT3
C 0.700 GeneticVariation CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500

2014
dbSNP: rs1057519767
rs1057519767
FLT3
C 0.700 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs1057519768
rs1057519768
FLT3
C 0.700 GeneticVariation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs1057519768
rs1057519768
FLT3
C 0.700 GeneticVariation CLINVAR Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies. 24619500

2014
dbSNP: rs1057519768
rs1057519768
FLT3
C 0.700 GeneticVariation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012