rs121913486
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs398122514
|
|
TGGATCC |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
|
11290608 |
2001 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
|
11290608 |
2001 |
rs121913488
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
|
11290608 |
2001 |
rs121913488
|
|
A |
0.740 |
CausalMutation |
CLINVAR |
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
|
11290608 |
2001 |
rs121913488
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
|
11290608 |
2001 |
rs121909646
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
|
11290608 |
2001 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
|
15256420 |
2004 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
|
15256420 |
2004 |
rs121913488
|
|
A |
0.740 |
CausalMutation |
CLINVAR |
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
|
15256420 |
2004 |
rs121913488
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.
|
14604974 |
2004 |
rs121913488
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
|
15256420 |
2004 |
rs121913488
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
|
15256420 |
2004 |
rs1057520023
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia.
|
14737077 |
2004 |
rs121909646
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.
|
15256420 |
2004 |
rs121909646
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells.
|
14604974 |
2004 |
rs121913487
|
|
T |
0.800 |
CausalMutation |
CLINVAR |
FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression.
|
15374878 |
2005 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression.
|
15374878 |
2005 |
rs1057519726
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia.
|
15863200 |
2005 |
rs1057520024
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant.
|
16091740 |
2005 |
rs1057520043
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Roles of tyrosine residues 845, 892 and 922 in constitutive activation of murine FLT3 kinase domain mutant.
|
16091740 |
2005 |
rs749281035
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
A novel FLT3 activation loop mutation N841K in acute myeloblastic leukemia.
|
15625552 |
2005 |
rs991132188
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3.
|
15667533 |
2005 |
rs121913487
|
|
C |
0.800 |
CausalMutation |
CLINVAR |
A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy.
|
16857985 |
2006 |