rs991132188
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3.
|
15667533 |
2005 |
rs772061268
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
FLT3 K663Q is a novel AML-associated oncogenic kinase: Determination of biochemical properties and sensitivity to Sunitinib (SU11248).
|
16990784 |
2006 |
rs759272576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Targeted next-generation sequencing at the time of AML progression on gilteritinib identified treatment-emergent mutations that activate RAS/MAPK pathway signaling, most commonly in <i>NRAS</i> or <i>KRAS.</i> Less frequently, secondary <i>FLT3</i>-F691L gatekeeper mutations or <i>BCR-ABL1</i> fusions were identified at progression.
|
31088841 |
2019 |
rs749281035
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
A novel FLT3 activation loop mutation N841K in acute myeloblastic leukemia.
|
15625552 |
2005 |
rs398122514
|
|
TGGATCC |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
rs376588714
|
|
C |
0.710 |
GeneticVariation |
CLINVAR |
Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD.
|
23430109 |
2013 |
rs376588714
|
|
C |
0.710 |
GeneticVariation |
CLINVAR |
Reversal of acquired drug resistance in FLT3-mutated acute myeloid leukemia cells via distinct drug combination strategies.
|
24619500 |
2014 |
rs376588714
|
|
C |
0.710 |
GeneticVariation |
CLINVAR |
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.
|
22504184 |
2012 |
rs376588714
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Identification of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with acute myeloid leukemia (AML).
|
15345593 |
2005 |
rs374234147
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified five IDH1 mutations that were novel to AML: (1) c.299 G>A, p.R100Q; (2) c.311G>T, p.G104V; (3) c.322T>C, p.F108L; (4) c.356G>A, p.R119Q; and (5) c.388A>G, p.I130V.
|
24376688 |
2013 |
rs35602083
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The FLT3 D324N variant was present in 42 cases (6.4%), but it was not associated with a specific AML subtype and did not show an elevated leukocyte count, as do other FLT3 mutations.
|
16320249 |
2006 |
rs1244282842
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia.
|
26823947 |
2016 |
rs121913491
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
rs121913490
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
rs121913488
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
rs121913488
|
|
A |
0.740 |
CausalMutation |
CLINVAR |
Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia.
|
22504183 |
2012 |
rs121913488
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia.
|
23783394 |
2013 |
rs121913488
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD.
|
23430109 |
2013 |
rs121913488
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.
|
22368270 |
2012 |
rs121913488
|
|
A |
0.740 |
CausalMutation |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
rs121913488
|
|
G |
0.740 |
CausalMutation |
CLINVAR |
Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia.
|
22504184 |
2012 |
rs121913488
|
|
A |
0.740 |
CausalMutation |
CLINVAR |
Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation.
|
22368270 |
2012 |
rs121913488
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Mutational landscape of AML with normal cytogenetics: biological and clinical implications.
|
23261068 |
2013 |
rs121913488
|
|
T |
0.740 |
CausalMutation |
CLINVAR |
Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3.
|
20733134 |
2010 |
rs121913488
|
|
A |
0.740 |
CausalMutation |
CLINVAR |
Recurring mutations found by sequencing an acute myeloid leukemia genome.
|
19657110 |
2009 |