Gene: FLT3 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913488
rs121913488
FLT3
A 0.740 CausalMutation CLINVAR Sensitivity toward sorafenib and sunitinib varies between different activating and drug-resistant FLT3-ITD mutations. 17889720

2007
dbSNP: rs121913488
rs121913488
FLT3
0.740 GeneticVariation BEFREE Our FLT3-Aurora kinase inhibitor, CCT137690, successfully inhibited growth of FLT3-ITD-D835Y cells in vitro and in vivo, suggesting that dual FLT3-Aurora inhibition may overcome selective FLT3 inhibitor resistance, in part due to inhibition of Aurora kinase, and may benefit patients with FLT3-mutated AML. 22354205

2012
dbSNP: rs121913488
rs121913488
FLT3
G 0.740 CausalMutation CLINVAR Mutational landscape of AML with normal cytogenetics: biological and clinical implications. 23261068

2013
dbSNP: rs121913488
rs121913488
FLT3
G 0.740 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913488
rs121913488
FLT3
T 0.740 CausalMutation CLINVAR The role of kinase inhibitors in the treatment of patients with acute myeloid leukemia. 23714533

2013
dbSNP: rs121913488
rs121913488
FLT3
A 0.740 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913488
rs121913488
FLT3
A 0.740 CausalMutation CLINVAR Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. 15256420

2004
dbSNP: rs121913488
rs121913488
FLT3
G 0.740 CausalMutation CLINVAR Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways. 17047150

2007
dbSNP: rs121913488
rs121913488
FLT3
T 0.740 CausalMutation CLINVAR Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia. 23321257

2013
dbSNP: rs121913488
rs121913488
FLT3
A 0.740 CausalMutation CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985

2006
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Prospective evaluation of gene mutations and minimal residual disease in patients with core binding factor acute myeloid leukemia. 23321257

2013
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. 11290608

2001
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. 22504183

2012
dbSNP: rs121913487
rs121913487
FLT3
C 0.800 CausalMutation CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985

2006
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. 20733134

2010
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Activity of ponatinib against clinically-relevant AC220-resistant kinase domain mutants of FLT3-ITD. 23430109

2013
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Recurring mutations found by sequencing an acute myeloid leukemia genome. 19657110

2009
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy. 16857985

2006
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. 22368270

2012
dbSNP: rs121913487
rs121913487
FLT3
C 0.800 CausalMutation CLINVAR Mutational landscape of AML with normal cytogenetics: biological and clinical implications. 23261068

2013
dbSNP: rs121913487
rs121913487
FLT3
T 0.800 CausalMutation CLINVAR Mutational landscape of AML with normal cytogenetics: biological and clinical implications. 23261068

2013
dbSNP: rs121913487
rs121913487
FLT3
C 0.800 CausalMutation CLINVAR Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518. 15256420

2004
dbSNP: rs121913487
rs121913487
FLT3
C 0.800 CausalMutation CLINVAR Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. 22504184

2012