|
rs352140
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A significant genotypic and allelic association was revealed between TLR-9-rs352140 and both SLE and LN (P < 0·05).
|
28763101 |
2017 |
|
rs61752717
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single patient in the SLE-Nephritis group was compound heterozygous for M694V/M680I mutations and only one patient in the SLE-Mild group was homozygous for E148Q mutation.
|
25413357 |
2015 |
|
rs11893826
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 111 patients with SLE (50 with SLE without nephritis, 55 with LN and 6 with simple urinary sediment abnormalities) and 62 healthy controls (HC) were genotyped for NCX1 rs11893826 (NCX1a) and rs434082 (NCX1b) and ADD2 rs4984 SNPs.
|
26045217 |
2015 |
|
rs434082
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 111 patients with SLE (50 with SLE without nephritis, 55 with LN and 6 with simple urinary sediment abnormalities) and 62 healthy controls (HC) were genotyped for NCX1 rs11893826 (NCX1a) and rs434082 (NCX1b) and ADD2 rs4984 SNPs.
|
26045217 |
2015 |
|
rs4984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 111 patients with SLE (50 with SLE without nephritis, 55 with LN and 6 with simple urinary sediment abnormalities) and 62 healthy controls (HC) were genotyped for NCX1 rs11893826 (NCX1a) and rs434082 (NCX1b) and ADD2 rs4984 SNPs.
|
26045217 |
2015 |
|
rs2246614
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs4963128 and rs2246614 were correlated with a variety of clinical subphenotypes, such as lupus nephritis, arthritis, and the production of anti-SSA/B autoantibodies, despite a lack of significant association between these two SNPs and SLE disease susceptibility in general.
|
21167895 |
2011 |
|
rs2298804
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although we did not find any significant correlation between the rs2298804 and the incidence of lupus nephritis, rs2298804 seemed to protect against proteinunia, fever and hypocomplementaemia in patients with SLE, but appeared to be a risk factor for photosensitivity and vasculitis.
|
23621092 |
2013 |
|
rs352139
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both rs352139 (p=0.040, OR: 0.713, 95%CI: 0.516-0.985) and rs352140 (p=0.048, OR: 0.723, 95%CI: 0.525-0.997) were associated with LN in dominant model.
|
20497632 |
2010 |
|
rs352140
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Both rs352139 (p=0.040, OR: 0.713, 95%CI: 0.516-0.985) and rs352140 (p=0.048, OR: 0.723, 95%CI: 0.525-0.997) were associated with LN in dominant model.
|
20497632 |
2010 |
|
rs11203368
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriage of minor alleles of five other SNPs (rs11203366, rs11203367, rs874881, rs2240340, and rs11203368) was associated with increased occurrence of LN and hypertension.
|
30269634 |
2019 |
|
rs7708392
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Comparing cases of systemic lupus erythematosus with nephritis and cases of systemic lupus erythematosus without nephritis revealed strong associations with lupus nephritis at rs7708392 in European Americans and rs4958881 in African Americans.
|
23970121 |
2013 |
|
rs4958881
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Comparing cases of systemic lupus erythematosus with nephritis and cases of systemic lupus erythematosus without nephritis revealed strong associations with lupus nephritis at rs7708392 in European Americans and rs4958881 in African Americans.
|
23970121 |
2013 |
|
rs1143679
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Conclusion CD11b rs1143679 appears to be associated with risk for SLE in the Han Chinese population, and may play an important role in the development of lupus nephritis.
|
29207897 |
2018 |
|
rs17008504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1).
|
26509176 |
2015 |
|
rs2271100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1).
|
26509176 |
2015 |
|
rs6056923
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1).
|
26509176 |
2015 |
|
rs1391441
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1).
|
26509176 |
2015 |
|
rs3824662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
GATA3 rs3824662 is not associated with susceptibility to SLE either in adult or in pediatric patients; however, in pSLE patients, the heterozygous AC genotype could be considered a risk factor for LN.
|
30301440 |
2018 |
|
rs6478109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypes distribution of rs6478109, rs7848647 were strongly related to lupus nephritis within SLE (p = 0.004, p = 0.011), respectively.
|
31081141 |
2019 |
|
rs7848647
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypes distribution of rs6478109, rs7848647 were strongly related to lupus nephritis within SLE (p = 0.004, p = 0.011), respectively.
|
31081141 |
2019 |
|
rs1799964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we aimed to examine whether the TNF -238G/A, -308G/A, -376G/A (rs1800750), and -1031T/C (rs1799964) polymorphisms confer SLE or lupus nephritis (LN) susceptibility in a Mexican population.
|
29611038 |
2018 |
|
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL-17A rs2275913, IL-17F rs763780 and rs2397084 are not related to the LN development, SLE disease activity or overall survival.
|
26515887 |
2016 |
|
rs763780
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL-17A rs2275913, IL-17F rs763780 and rs2397084 are not related to the LN development, SLE disease activity or overall survival.
|
26515887 |
2016 |
|
rs2397084
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL-17A rs2275913, IL-17F rs763780 and rs2397084 are not related to the LN development, SLE disease activity or overall survival.
|
26515887 |
2016 |
|
rs11889341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the case-control analysis of cohort I, four highly linked SNPs in STAT4 were associated with lupus nephritis with genome wide significance with p = 3.7 × 10(-9), OR 2.20 for the best SNP rs11889341.
|
24386384 |
2013 |