|
rs10127939
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The low-binding haplotypes formed by 66L/R/H and 176F confer enhanced risk of lupus nephritis in African Americans.
|
24782186 |
2014 |
|
rs1061170
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was a significantly higher ratio of CC/CT genotypes of rs1061170 in lupus nephritis patients with class III than in the other two classes (class III vs. class IV vs. class V: 21.0% vs. 9.7% vs. 9.4%; P = .044).
|
28403670 |
2017 |
|
rs11057864
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Response to Intravenous Cyclophosphamide Treatment for Lupus Nephritis Associated with Polymorphisms in the FCGR2B-FCRLA Locus.
|
26980576 |
2016 |
|
rs1108131
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Response to Intravenous Cyclophosphamide Treatment for Lupus Nephritis Associated with Polymorphisms in the FCGR2B-FCRLA Locus.
|
26980576 |
2016 |
|
rs11203368
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriage of minor alleles of five other SNPs (rs11203366, rs11203367, rs874881, rs2240340, and rs11203368) was associated with increased occurrence of LN and hypertension.
|
30269634 |
2019 |
|
rs1143679
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Conclusion CD11b rs1143679 appears to be associated with risk for SLE in the Han Chinese population, and may play an important role in the development of lupus nephritis.
|
29207897 |
2018 |
|
rs1143679
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our meta-analyses confirm that the ITGAM rs1143679 polymorphism is associated with SLE susceptibility in different ethnic groups and demonstrate that the polymorphism is associated with LN in European.
|
25315704 |
2015 |
|
rs114580964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We discovered five independent risk variants for LN within the MHC region, including <i>HLA-DRβ1</i> amino acid 11 (<i>P</i><sub>omnibus</sub><0.001), <i>HLA-DQβ1</i> amino acid 45 (<i>P</i><0.001; odds ratio, 0.58; 95% confidence interval, 0.52 to 0.65), <i>HLA-A</i> amino acid 156 (<i>P</i><sub>omnibus</sub><0.001), <i>HLA-DPβ1</i> amino acid 76 (<i>P</i><sub>omnibus</sub><0.001), and a missense variant in <i>PRRC2A</i> (rs114580964; <i>P</i><0.001; odds ratio, 0.38; 95% confidence interval, 0.30 to 0.49) at genome-wide significance.
|
28754791 |
2017 |
|
rs117026326
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients carrying genotype TT of rs117026326 had lower 24-hour urinary total protein (24 hours UTP, g/24 hours), 24-hour urinary protein level (g/L·24 hours), lower frequency of the proteinuria and lupus nephritis (LN).
|
31374066 |
2019 |
|
rs11889341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the case-control analysis of cohort I, four highly linked SNPs in STAT4 were associated with lupus nephritis with genome wide significance with p = 3.7 × 10(-9), OR 2.20 for the best SNP rs11889341.
|
24386384 |
2013 |
|
rs11893826
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 111 patients with SLE (50 with SLE without nephritis, 55 with LN and 6 with simple urinary sediment abnormalities) and 62 healthy controls (HC) were genotyped for NCX1 rs11893826 (NCX1a) and rs434082 (NCX1b) and ADD2 rs4984 SNPs.
|
26045217 |
2015 |
|
rs11981433
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found no association of PON2 SNPs with SLE risk but modest associations were observed with lupus nephritis (rs11981433, rs17876205, rs17876183) and immunologic disorder (rs11981433) in SLE patients (P = 0.013 to 0.042).
|
21223581 |
2011 |
|
rs1267969615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no association between genetic polymorphism of ACE, AGT M235T and AGTR1 A1166C and susceptibility to lupus nephritis, nor histological activity and chronicity indices in renal biopsy among the patients studied.
|
16047641 |
2005 |
|
rs1364989
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.
|
24925725 |
2014 |
|
rs1391441
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1).
|
26509176 |
2015 |
|
rs1456896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the rs1456896 A allele is associated with protective susceptibility to LN.
|
27684961 |
2017 |
|
rs1635564
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Notably, gene dose effects of the rs1635564 variant allele were observed for SLE (p = 0.005) and LN (p = 0.01).
|
30269634 |
2019 |
|
rs17008504
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1).
|
26509176 |
2015 |
|
rs172378
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results support the implication of the G allele in rs172378 as a risk factor for lupus nephritis in a homozygous status, at least for a Bulgarian population.
|
25326229 |
2015 |
|
rs1799964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we aimed to examine whether the TNF -238G/A, -308G/A, -376G/A (rs1800750), and -1031T/C (rs1799964) polymorphisms confer SLE or lupus nephritis (LN) susceptibility in a Mexican population.
|
29611038 |
2018 |
|
rs2004640
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results suggested that the rs2004640 T allele was associated with susceptibility to lupus nephritis and that the IRF5 polymorphism analyzed did not seem to be implicated in the pathology and clinical manifestation of lupus nephritis in the Chinese population.
|
21040166 |
2010 |
|
rs2157257
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multiple peaks of association exceeding a Bonferroni corrected P-value of P < 2.03 × 10(-3) were observed between LN and MYH9 in EAs (N = 4620), with the most pronounced association at rs2157257 (P = 4.7 × 10(-4), odds ratio (OR) = 1.205).
|
22189356 |
2012 |
|
rs2246614
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, rs4963128 and rs2246614 were correlated with a variety of clinical subphenotypes, such as lupus nephritis, arthritis, and the production of anti-SSA/B autoantibodies, despite a lack of significant association between these two SNPs and SLE disease susceptibility in general.
|
21167895 |
2011 |
|
rs2271100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four trans-eSNPs were observed to be associated with susceptibility to LN (P < 0.05), including ANKRD50 rs17008504, AGA rs2271100, PAK7 rs6056923, and TET2 rs1391441, while seven other trans-eSNPs showed marginal significant associations (0.05 < P < 0.1).
|
26509176 |
2015 |
|
rs2275913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
IL-17A rs2275913, IL-17F rs763780 and rs2397084 are not related to the LN development, SLE disease activity or overall survival.
|
26515887 |
2016 |