|
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
in a cohort from a population with the world's third highest incidence of KD, we demonstrated that the C-allele of ITPKC SNP rs28493229 is associated with KD susceptibility and BCG scar reactivation during the acute phase, although its frequency is lower than that in the Japanese cohort (22.6%), suggesting this SNP contributes to KD susceptibility through induced hyperimmune function reflected in the BCG reactivation.
|
20805785 |
2011 |
|
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
In conclusion, we did not find a statistically significant association between the ITPKC gene SNP rs28493229 and KD or CALs in Taiwanese children.
|
20045869 |
2010 |
|
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) gene rs28493229 was recently found to be associated with the risk for KD in the Japanese population, suggesting that the ITPKC gene may contribute to KD susceptibility.
|
22361738 |
2012 |
|
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Recently, a single nucleotide polymorphism (SNP) of the inositol 1,4,5-triphosphate kinase C (ITPKC), rs28493229, was found to passively confer susceptibility for Kawasaki syndrome (KS) and subsequent coronary arterial lesions.
|
22498790 |
2012 |
|
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Taken together, our results indicated that C-allele of ITPKC SNP rs284</span>93229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population.
|
21533171 |
2011 |
|
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Functional single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC) (rs28493229) and caspase-3 (CASP3) (rs113420705; formerly rs72689236) are associated with susceptibility to Kawasaki's disease (KD).
|
21987091 |
2013 |
|
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
SNP rs28493229 in ITPKC was associated with KD and coronary artery complications.
|
29214786 |
2018 |
|
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
This meta-analysis reveals that the functional polymorphism rs28493229 in ITPKC significantly contributes to the risk of KD.
|
23065250 |
2012 |
|
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The meta-analyses first revealed significant risk for CALs in KD patients carrying risk allele of rs11340705, and the association of rs28493229 with KD was not observed in the Han Chinese.
|
23456091 |
2013 |
|
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
In a meta-analysis with 1,461 cases and 5,302 controls, a very strong association of KD with the nonsynonymous SNP rs1801274 (p.His167Arg, previously assigned as p.His131Arg) in FCGR2A was confirmed in males (OR = 1.48, P = 1.43 × 10-7), but not in the females (OR = 1.17, P = 0.055).
|
28886140 |
2017 |
|
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
These results further confirm that rs1801274 in the FCGR2A gene is significantly associated with increased risk of KD.
|
25093412 |
2014 |
|
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Compared with their respective wild type counterparts, rs1801274 AG+GG genotypes and rs3818298 TC+CC genotypes were nominally associated with the reduced risk of KD (OR = 0.77, 95% CI = 0.59-0.99, P = 0.045; OR = 0.74, 95% CI = 0.56-0.98, P = 0.038).
|
25645453 |
2015 |
|
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the FCGR2A rs1801274 G-allele confers susceptibility to KD and UC.
|
27270653 |
2016 |
|
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Significant susceptibility to CALs was found in KD patients with high-risk genotypes at both rs1801274 and rs2857151.
|
23456091 |
2013 |
|
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease.
|
22446962 |
2012 |
|
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
We performed a genetic association analysis in several KD subgroups categorized by clinical characteristics using the KD-associated variants of the B lymphoid tyrosine kinase (<i>BLK</i>; rs6993775) and Fc gamma receptor II a (<i>FCGR2A</i>; rs1801274) in a large number of case (n=1,011) and control (n=4,533) samples.
|
30468029 |
2019 |
|
rs1801274
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Now, we show in 1,028 European KD patients that the <i>FCGR2C</i>-ORF haplotype, although nearly absent in Asians, was more strongly associated with susceptibility to KD than rs1801274 in Europeans.
|
30949161 |
2019 |
|
rs2254546
|
|
|
0.820 |
GeneticVariation |
BEFREE |
In conclusion, rs2254546 polymorphism might significantly contribute to the risk of KD.
|
24577620 |
2014 |
|
rs2254546
|
|
|
0.820 |
GeneticVariation |
BEFREE |
As a result, the risk alleles of rs1801274 and rs2254546 were observed significant effect on KD with higher frequencies in 358 patients than those in 815 controls.
|
23456091 |
2013 |
|
rs2736340
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Stratification analysis by diseases suggested FAM167A-BLK rs2736340 had a positive association with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc) and Kawasaki disease, primary Sjogren's syndrome (pSS), primary antiphosholipid syndrome (APS), and myositis.
|
27105348 |
2016 |
|
rs2736340
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Within the BLK gene the rs2736340-located linkage disequilibrium (LD ) comprising the promoter and first intron was strongly associated with KD, with the combined results of Asian studies including Taiwanese, Japanese, and Korean populations (2,539 KD patients and 7,021 controls) providing very compelling evidence of association (rs2736340, OR = 1.498, 1.354-1.657; P = 4.74×10(-31)).
|
24023612 |
2013 |
|
rs2857151
|
|
|
0.810 |
GeneticVariation |
BEFREE |
The significant role of rs1801274, rs2857151 and rs2254546 in KD was found in the multi-variable logistic regression analysis of the SNPs.
|
23456091 |
2013 |
|
rs4813003
|
|
|
0.810 |
GeneticVariation |
BEFREE |
In conclusion, our study suggests that 4 GWAS-identified SNPs, rs2736340, rs4813003, rs3818298 and rs1801274, were nominally associated with KD risk in a Han Chinese population individually and jointly.
|
25645453 |
2015 |
|
rs527409
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Of these, one locus on chromosome 1p31 (rs527409) was replicated in 266 children with KD and 600 normal controls (odds ratio [OR] = 2.90, 95% confidence interval [CI] = 1.85-4.54, P (combined) = 1.46 × 10(-6)); and a PELI1 locus on chromosome 2p13.3 (rs7604693) was replicated in 86 KD patients with CALs and 600 controls (OR = 2.70, 95% CI = 1.77-4.12, P (combined) = 2.00 × 10(-6)).
|
21221998 |
2011 |
|
rs6993775
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Six single-nucleotide polymorphisms (SNPs) in three loci were associated significantly with KD susceptibility (P<1.0 × 10<sup>-5</sup>), including the previously reported BLK locus (rs6993775, odds ratio (OR)=1.52, P=2.52 × 10<sup>-11</sup>).
|
28855716 |
2017 |