|
rs28662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To identify genetic variants influencing IVIG non-response in KD, a genome-wide association study (GWAS) and a replication study were performed using a total of 148 IVIG non-responders and 845 IVIG-responders in a Korean population. rs28662 in the sterile alpha motif domain-containing protein 9-like (SAMD9L) locus showed the most significant result in the joint analysis of GWAS and replication samples (odds ratio (OR) = 3.47, P = 1.39 × 10<sup>-5</sup>).
|
30971808 |
2020 |
|
rs1143627
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicated that there was no association between the rs16944 A/G and rs1143627 G/A gene polymorphisms and KD susceptibility.
|
31093510 |
2019 |
|
rs11614913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that miRNA-196a2 rs11614913 T>C may not be associated with Kawasaki disease susceptibility in a southern Chinese population.
|
31131489 |
2019 |
|
rs12041331
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant differences in the frequency of rs12566888 or rs12041331 in PEAR1 were observed between KD and healthy controls.
|
30256383 |
2019 |
|
rs1412125
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs1412125 in HMGB1 might be a risk factor for the development of coronary artery lesions and IVIG resistance in KD patients.
|
30535242 |
2019 |
|
rs16944
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicated that there was no association between the rs16944 A/G and rs1143627 G/A gene polymorphisms and KD susceptibility.
|
31093510 |
2019 |
|
rs2254556
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a genetic approach, from the nine single nucleotide variants (SNVs) associated with KD susceptibility in children of European descent, we identified SNVs near the HLA-C (rs6906846) and HLA-B genes (rs2254556) whose association was replicated in a Japanese descent cohort (rs6906846 p = 0.01, rs2254556 p = 0.005).
|
31122742 |
2019 |
|
rs2292832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicated that in southern Chinese patients, the miRNA-149 rs2292832 T>C polymorphism did not affect KD susceptibility, which needs to be further confirmed.
|
31785027 |
2019 |
|
rs4919510
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However in an analysis stratified by age, gender, and coronary artery lesion (CAL), we found a relationship between the <i>miRNA-608</i> rs4919510 G>C polymorphism and KD susceptibility.
|
31043452 |
2019 |
|
rs5050
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An Angiotensinogen Gene Polymorphism (rs5050) Is Associated with the Risk of Coronary Artery Aneurysm in Southern Chinese Children with Kawasaki Disease.
|
30719178 |
2019 |
|
rs5050
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicate that the AGT gene polymorphism rs5050T>G may increase the risk of CAA in children with KD, especially those who are younger than 12 months.
|
30719178 |
2019 |
|
rs57095329
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In KD-CAL group, the allele frequency of A was higher than that in KD-WO group at locus rs57095329 A/G polymorphisms of miR-146a gene (χ<sup>2</sup> = 4.745, P = 0.035), carriers with allele A were at 2.422 times higher risk of getting coronary artery lesions than those of non-carriers (χ<sup>2</sup> = 4.745, P = 0.035, OR = 2.422, 95%CI = 1.073-5.465), while there was no significant difference of genotype frequency of AA, AG, and GG types between KD-CAL group and KD-WO group (P > 0.05).
|
30291383 |
2019 |
|
rs6864584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no significant difference of genotype frequencies of TT, TC, and CC types and allele frequencies of T and C types between KD-CAL group and KD-WO group at locus rs6864584 T/C polymorphisms of miR-146a gene (P > 0.05).
|
30291383 |
2019 |
|
rs689466
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The AA genotype and A allele of rs689466 confer predisposing factors to KD.
|
30321073 |
2019 |
|
rs6906846
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a genetic approach, from the nine single nucleotide variants (SNVs) associated with KD susceptibility in children of European descent, we identified SNVs near the HLA-C (rs6906846) and HLA-B genes (rs2254556) whose association was replicated in a Japanese descent cohort (rs6906846 p = 0.01, rs2254556 p = 0.005).
|
31122742 |
2019 |
|
rs7637803
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, we found a significant relationship between rs7637803 and CAA risk in KD patients [CT versus CC: odds ratio (OR) = 0.41, 95% confidence interval (CI) = 0.22-0.75; p = 0.0041; TT versus CC: OR = 2.90, 95% CI = 1.12-7.46; p = 0.0276].
|
30576025 |
2019 |
|
rs1042579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In our study, we examined the <i>TM</i> C14</span>18T polymorphism in 122 children with K</span>D and 126 healthy children and revealed the correlation between the <i>TM</i> C1418T polymorphism and KD, CAL formation, and IVIG resistance.
|
30008974 |
2018 |
|
rs10866845
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphism of rs10866845 showed a significant difference in allele frequency between KD patients and controls (p=0.040).
|
29749135 |
2018 |
|
rs1113452
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study demonstrated that the <i>miR-218</i> rs1113452 A>G polymorphism may have an age-related relationship with KD susceptibility that has not previously been revealed.
|
29717030 |
2018 |
|
rs11134527
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results illustrated that the <i>miR-218</i> rs11134527 A>G polymorphism was not associated with KD risk.
|
29717030 |
2018 |
|
rs1625579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicate that the rs1625579 T>G polymorphism confers a risk of early-onset KD in southern Chinese children.
|
30122962 |
2018 |
|
rs4523
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, the TBXA2R rs4523 G allele may contribute to protection against Kawasaki disease and decreased risk of coronary artery aneurysm complications in a southern Chinese population.
|
30179800 |
2018 |
|
rs77624405
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs77624405 in SLC11A1 was associated with KD.
|
29214786 |
2018 |
|
rs7986087
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the rs7986087 T variant genotype was associated with significantly higher susceptibility to KD (adjusted OR = 1.30, 95% CI = 1.05-1.60 for rs7986087 CT/TT).
|
30363999 |
2018 |
|
rs868853
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the rs868853 T variant genotype was associated with significantly lower susceptibility to KD (adjusted OR = 0.74, 95% CI = 0.59-0.92 for rs868853 CT/CC).
|
30363999 |
2018 |