|
rs76863441
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that the V279F polymorphism in the plasma PAF-AH gene and consequent enzymatic deficiency is one of the factors for IVIG nonresponse in Japanese patients with acute KD.
|
16027700 |
2005 |
|
rs3025039
|
|
|
0.020 |
GeneticVariation |
BEFREE |
An association with susceptibility to KD was observed with 2 of the 6 single-nucleotide polymorphisms analyzed in VEGF: -2594 A>C (rs699947) and the 236 bp 3' of STP C>T (rs3025039).
|
16645995 |
2006 |
|
rs2010963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype CGCC (based on rs699947, rs2010963, rs25648, and rs3025039) was significantly associated with the development of KD (hap score 3.8; P = 0.0002).
|
16645995 |
2006 |
|
rs25648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype CGCC (based on rs699947, rs2010963, rs25648, and rs3025039) was significantly associated with the development of KD (hap score 3.8; P = 0.0002).
|
16645995 |
2006 |
|
rs699947
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An association with susceptibility to KD was observed with 2 of the 6 single-nucleotide polymorphisms analyzed in VEGF: -2594 A>C (rs699947) and the 236 bp 3' of STP C>T (rs3025039).
|
16645995 |
2006 |
|
rs12722477
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the fine mapping of the HLA-G locus, in particular, a nonsynonymous SNP (C/A) of the HLA-G gene (rs12722477, Leu134Ile) was significantly associated with Kawasaki disease (OR = 3.23, 95% CI = 1.12-9.32).
|
18976687 |
2008 |
|
rs2523790
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, only one candidate locus (HLA-G) was confirmed to have a significant association with Kawasaki disease (rs2523790, odds ratio [OR] = 3.00, 95% confidence interval [95% CI] = 1.14-7.91, uncorrected p = 0.0263) in the replication study using 44 new case subjects and the previous 90 controls.
|
18976687 |
2008 |
|
rs3743930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Lack of association between E148Q MEFV variant and Kawasaki disease.
|
19026701 |
2009 |
|
rs3755724
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele (C) of rs3755724 showed the susceptibility of CALs to risk in KD pati</span>ents.
|
19048177 |
2009 |
|
rs17531088
|
|
T |
0.800 |
GeneticVariation |
GWASCAT |
Significant associations of 40 SNPs and six haplotypes, identifying 31 genes, were replicated in an independent cohort of 583 predominantly Caucasian KD families, with NAALADL2 (rs17531088, p(combined) = 1.13 x 10(-6)) and ZFHX3 (rs7199343, p(combined) = 2.37 x 10(-6)) most significantly associated.
|
19132087 |
2009 |
|
rs17531088
|
|
T |
0.800 |
GeneticVariation |
GWASDB |
Significant associations of 40 SNPs and six haplotypes, identifying 31 genes, were replicated in an independent cohort of 583 predominantly Caucasian KD families, with NAALADL2 (rs17531088, p(combined) = 1.13 x 10(-6)) and ZFHX3 (rs7199343, p(combined) = 2.37 x 10(-6)) most significantly associated.
|
19132087 |
2009 |
|
rs549908
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that 105A/C polymorphism and the haplotypes in IL-18 gene are associated with the risk of KD in Taiwanese population.
|
19288449 |
2009 |
|
rs2227981
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PD-1 rs2227981 polymorphism was not significant in patients with KD comparing with the control group (p = 0.4, OR = 1.2 (0.8-1.9)).
|
19468750 |
2010 |
|
rs4290270
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotype analysis of rs7305115 and rs4290270 showed no significant differences between KD and control groups.
|
19763617 |
2010 |
|
rs7305115
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotype analysis of rs7305115 and rs4290270 showed no significant differences between KD and control groups.
|
19763617 |
2010 |
|
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
In conclusion, we did not find a statistically significant association between the ITPKC gene SNP rs28493229 and KD or CALs in Taiwanese children.
|
20045869 |
2010 |
|
rs738792
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP (rs738792) showed a statistically significant association with KD in the codominant (OR=1.61, 95% CI=1.11-2.34, P=0.011) and dominant (OR=1.92, 95% CI=1.21-3.06, P=0.006) models.
|
20230842 |
2010 |
|
rs2232367
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aims of this study were: 1) to investigate forkhead box P3 (FOXP3) expression in patients with Kawasaki disease (KD), exploring possible differences during the acute phase and after defervescence; 2) to evaluate a possible association of the FOXP3 single nucleotide polymorphism (SNP) 543 (SNP ID: rs2232367) with KD.
|
20412712 |
2010 |
|
rs2076311
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypic and allelic frequencies analyses found A allele at rs2076311 as a risk allele for KD.
|
20618517 |
2010 |
|
rs2229634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study evaluates the single nucleotide polymorphisms (SNP) rs22</span>29634 in the ITPR3 gene with KD in a case-control study involving 93 KD patients and 680 healthy, gender- and age-matched controls.
|
20618519 |
2010 |
|
rs28493229
|
|
|
0.890 |
GeneticVariation |
BEFREE |
in a cohort from a population with the world's third highest incidence of KD, we demonstrated that the C-allele of ITPKC SNP rs28493229 is associated with KD susceptibility and BCG scar reactivation during the acute phase, although its frequency is lower than that in the Japanese cohort (22.6%), suggesting this SNP contributes to KD susceptibility through induced hyperimmune function reflected in the BCG reactivation.
|
20805785 |
2011 |
|
rs231775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CTLA-4, position 49 A/G polymorphism associated with coronary artery lesions in Kawasaki disease.
|
21082224 |
2011 |
|
rs4776338
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A SMAD3 haplotype associated with KD susceptibility replicated in 2 independent cohorts and an intronic single nucleotide polymorphism in a separate haplotype block was also strongly associated (A/G, rs4776338) (P=0.000022; odds ratio, 1.50; 95% confidence interval, 1.25 to 1.81).
|
21127203 |
2011 |
|
rs527409
|
|
T |
0.810 |
GeneticVariation |
GWASDB |
Of these, one locus on chromosome 1p31 (rs527409) was replicated in 266 children with KD and 600 normal controls (odds ratio [OR] = 2.90, 95% confidence interval [CI] = 1.85-4.54, P (combined) = 1.46 × 10(-6)); and a PELI1 locus on chromosome 2p13.3 (rs7604693) was replicated in 86 KD patients with CALs and 600 controls (OR = 2.70, 95% CI = 1.77-4.12, P (combined) = 2.00 × 10(-6)).
|
21221998 |
2011 |
|
rs527409
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Of these, one locus on chromosome 1p31 (rs527409) was replicated in 266 children with KD and 600 normal controls (odds ratio [OR] = 2.90, 95% confidence interval [CI] = 1.85-4.54, P (combined) = 1.46 × 10(-6)); and a PELI1 locus on chromosome 2p13.3 (rs7604693) was replicated in 86 KD patients with CALs and 600 controls (OR = 2.70, 95% CI = 1.77-4.12, P (combined) = 2.00 × 10(-6)).
|
21221998 |
2011 |