|
rs56151798
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No association was observed between this TPH T1095C variant with either OCD, AN, Alc, or suicidality.
|
10088048 |
1999 |
|
rs4680
|
|
|
0.090 |
GeneticVariation |
BEFREE |
This polymorphism (valine to methionine at codon 158) has been previously reported to influence the activity of COMT by three to four-fold and has recently been reported to be associated with OCD.1 We tested for linkage using an autosomal dominant model with reduced penetrance and non-parametric methods.
|
10523824 |
1999 |
|
rs6296
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From the three reported family-based case control studies of HTR1B to various disorders, one provides preliminary evidence for association of G861C with obsessive compulsive disorder.
|
12437478 |
2002 |
|
rs6313
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The -1438 G/A and T102C polymorphisms of the 5-HT2A receptor gene are not associated with an increased risk of OCD.
|
12927326 |
2003 |
|
rs1799971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied two single nucleotide polymorphisms (C17T and A118G) in 51 trios with OCD.
|
15108189 |
2004 |
|
rs1799972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied two single nucleotide polymorphisms (C17T and A118G) in 51 trios with OCD.
|
15108189 |
2004 |
|
rs4680
|
|
|
0.090 |
GeneticVariation |
BEFREE |
These results do not support the hypothesis that the COMT Val158Met gene polymorphism is associated with liability to schizophrenia-OCD.
|
16043283 |
2005 |
|
rs4565946
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this first study of TPH2 in OCD, analysis of the SNPs, rs4570625 and rs4565946, revealed a significant preferential transmission of haplotype G-C to children and adolescents with OCD.
|
16146581 |
2006 |
|
rs4570625
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this first study of TPH2 in OCD, analysis of the SNPs, rs4570625 and rs4565946, revealed a significant preferential transmission of haplotype G-C to children and adolescents with OCD.
|
16146581 |
2006 |
|
rs4680
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In subjects of Afrikaner descent, the L/L genotype of the COMT Val158Met polymorphism was significantly more common in the OCD hoarding group, with a preponderance of low activity alleles, compared with nonhoarding patients and controls.
|
16187774 |
2005 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A strong association of the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder (OCD) has been reported.
|
16541456 |
2006 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A strong association of the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder (OCD) has been reported.
|
16541456 |
2006 |
|
rs746682028
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A strong association of the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder (OCD) has been reported.
|
16541456 |
2006 |
|
rs301434
|
|
|
0.040 |
GeneticVariation |
BEFREE |
After correction for multiple comparisons, 2 variants, rs301434 (chi 2 = 12.04; P = .006) and rs301435 (chi 2 = 9.24; P = .03), located within a single haplotype block were found to be associated with transmission of OCD.
|
16818866 |
2006 |
|
rs301435
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple comparisons, 2 variants, rs301434 (chi 2 = 12.04; P = .006) and rs301435 (chi 2 = 9.24; P = .03), located within a single haplotype block were found to be associated with transmission of OCD.
|
16818866 |
2006 |
|
rs6311
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Nominally significant association was found at the HTR2A rs6311 polymorphism in subjects with tic disorder and OCD (p = .05), replicating a previous finding in Tourette syndrome and OCD.
|
17241828 |
2007 |
|
rs762178
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The following 3 single nucleotide polymorphism markers on OLIG2 were associated with the OCD without TD phenotype: rs762178 (minor allele frequency, 35%; P<.001), rs1059004 (minor allele frequency, 44%; P = .005), and rs9653711 (minor allele frequency, 44%; P = .004).
|
17283288 |
2007 |
|
rs9653711
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The following 3 single nucleotide polymorphism markers on OLIG2 were associated with the OCD without TD phenotype: rs762178 (minor allele frequency, 35%; P<.001), rs1059004 (minor allele frequency, 44%; P = .005), and rs9653711 (minor allele frequency, 44%; P = .004).
|
17283288 |
2007 |
|
rs1059004
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The following 3 single nucleotide polymorphism markers on OLIG2 were associated with the OCD without TD phenotype: rs762178 (minor allele frequency, 35%; P<.001), rs1059004 (minor allele frequency, 44%; P = .005), and rs9653711 (minor allele frequency, 44%; P = .004).
|
17283288 |
2007 |
|
rs13046814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 5-marker haplotype (A/C/T/T/G) constituting these single nucleotide polymorphisms and exonic single nucleotide polymorphisms rs6517137 and rs13046814 was undertransmitted (frequency, 32%; permuted P=.004), whereas the G/A/T/T/C haplotype (frequency, 22%; permuted P=.02) was overtransmitted to probands with OCD alone, with a significant global P value (permuted P=.008).
|
17283288 |
2007 |
|
rs6517137
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 5-marker haplotype (A/C/T/T/G) constituting these single nucleotide polymorphisms and exonic single nucleotide polymorphisms rs6517137 and rs13046814 was undertransmitted (frequency, 32%; permuted P=.004), whereas the G/A/T/T/C haplotype (frequency, 22%; permuted P=.02) was overtransmitted to probands with OCD alone, with a significant global P value (permuted P=.008).
|
17283288 |
2007 |
|
rs25531
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Subgroups based on the age of OCD onset, gender, familiality, factor analysis-derived symptom dimensions, or comorbidity with other psychiatric disorders failed to identify SLC6A4- or BDNF-associated phenotypes, with one exception of overall number of comorbid anxiety disorders being significantly associated with 5-HTTLPR/rs25531.
|
17375136 |
2007 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD).
|
17853300 |
2008 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Investigating the role of the brain-derived neurotrophic factor (BDNF) val66met variant in obsessive-compulsive disorder (OCD).
|
17853300 |
2008 |
|
rs2378672
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association between a NTRK2 intronic SNP (rs2378672) and OCD was identified (p < .0001) in female patients under an additive model.
|
17884018 |
2008 |