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rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C677T and A1298C mutations of 5,10-methylenetetrahydrofolate reductase (MTHFR) have been linked with conditions such as depression, bipolar disorder, and schizophrenia, but there are not clear the relationship between MTHFR polymorphisms and obsessive-compulsive disorder (OCD).
|
30992611 |
2020 |
|
rs3785817
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our linkage disequilibrium analysis revealed that rs3859268-rs2879096-rs3785817 combined OCD and control groups constructed one haplotype block.
|
31818769 |
2020 |
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rs397507444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Roles of 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in early- and late-onset obsessive-compulsive disorder.
|
30992611 |
2020 |
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rs10042486
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We concluded that among the HTR1A polymorphisms, only the association of rs10042486 CT genotype and OCD was statistically significant.
|
30232922 |
2019 |
|
rs1800042
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No association of Gly272Asp polymorphism and OCD was observed in this study.
|
30232922 |
2019 |
|
rs1838733
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study is the first to verify the associations of single nucleotide polymorphisms rs1838733 of the PDE4D gene with obsessive-compulsive disorder in a Chinese Han population.
|
31469783 |
2019 |
|
rs2000292
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A transmission disequilibrium test for SNPs in HTR1B (rs2000292), SLC18A1 (rs6586896), GAD1 (rs3791860), and GAD2 (rs8190748) was performed in a total of 101 early-onset OCD trios, from which 26 trios were newly recruited for the purpose of the present analysis.
|
30351181 |
2019 |
|
rs3780413
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, we aimed to assess the association of SLC1A1 polymorphisms (rs301430, rs2228622 and rs3780413) with OCD and its clinical characteristics, as well as the importance of these SNPs in the response of OCD patients to SSRI pharmacotherapy.
|
30315580 |
2019 |
|
rs8190748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A transmission disequilibrium test for SNPs in HTR1B (rs2000292), SLC18A1 (rs6586896), GAD1 (rs3791860), and GAD2 (rs8190748) was performed in a total of 101 early-onset OCD trios, from which 26 trios were newly recruited for the purpose of the present analysis.
|
30351181 |
2019 |
|
rs17162912
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We attempt to replicate the GWAS finding by investigating the association of the DISP1 rs17162912 polymorphism with SRI response in our sample of 112 European Caucasian OCD patients.
|
29953682 |
2018 |
|
rs13316193
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While OXTR variants were not associated with the affected status of OCD or its clinical symptom dimensions, rs2268493 (p=0.00185) and rs13316193 (p=0.00461) of the OXTR gene were associated with the age at onset in patients with OCD.
|
28915380 |
2017 |
|
rs2254298
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In particular, the G-C-G haplotype of rs2268493-rs2254298-rs11316193 and the T-G-A haplotype of rs237887-rs2268490-rs4686301 were positively associated with late-onset OCD.
|
28915380 |
2017 |
|
rs2268490
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In particular, the G-C-G haplotype of rs2268493-rs2254298-rs11316193 and the T-G-A haplotype of rs237887-rs2268490-rs4686301 were positively associated with late-onset OCD.
|
28915380 |
2017 |
|
rs2268493
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In particular, the G-C-G haplotype of rs2268493-rs2254298-rs11316193 and the T-G-A haplotype of rs237887-rs2268490-rs4686301 were positively associated with late-onset OCD.
|
28915380 |
2017 |
|
rs237887
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In particular, the G-C-G haplotype of rs2268493-rs2254298-rs11316193 and the T-G-A haplotype of rs237887-rs2268490-rs4686301 were positively associated with late-onset OCD.
|
28915380 |
2017 |
|
rs4686301
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In particular, the G-C-G haplotype of rs2268493-rs2254298-rs11316193 and the T-G-A haplotype of rs237887-rs2268490-rs4686301 were positively associated with late-onset OCD.
|
28915380 |
2017 |
|
rs1148374
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CDH2 SNP, rs1120154, C-allele carriers were found to be significantly associated with lower risk to develop OCD compared to TT-homozygotes (OR = 0.49; 95% CI: 0.32-0.75; p < 0.001), and rs12605662 G-allele carriers were significantly associated with reduced risk OCD compared to TT-homozygotes (OR = 0.46; 95% CI: 0.30-0.71; p < 0.001), Furthermore, a single haplotype was found to infer an increased risk for OCD diagnosis (*rs8087457-rs1148374: A-T).
|
26093892 |
2016 |
|
rs1176744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant difference existed in the genotypic distribution of the HTR3B variant rs1176744 between individuals with OCD and controls (odds ratio [OR] = 0.74, 95% confidence interval [CI] = 0.60-0.91, P = 0.0043).
|
27616601 |
2016 |
|
rs12605662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CDH2 SNP, rs1120154, C-allele carriers were found to be significantly associated with lower risk to develop OCD compared to TT-homozygotes (OR = 0.49; 95% CI: 0.32-0.75; p < 0.001), and rs12605662 G-allele carriers were significantly associated with reduced risk OCD compared to TT-homozygotes (OR = 0.46; 95% CI: 0.30-0.71; p < 0.001), Furthermore, a single haplotype was found to infer an increased risk for OCD diagnosis (*rs8087457-rs1148374: A-T).
|
26093892 |
2016 |
|
rs2075507
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A sample of 199 patients with OCD and 200 healthy individuals was genotyped for -287A > G (rs2075507) and Val158Met (rs4680) single nucleotide polymorphisms (SNPs) by TaqMan(®) or restriction mapping.
|
26687156 |
2016 |
|
rs3758987
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analyses of OCD sub-phenotypes demonstrated significant associations between rs3758987 and early onset OCD in male subjects (OR = 0.49, CI = 0.31-0.79, P = 0.0031) and among rs6766410, rs6443930, and the cleaning dimension in female subjects (OR = 0.36, CI = 0.18-0.69, P = 0.0016 and OR = 0.47, CI = 0.29-0.79, P = 0.0030, respectively).
|
27616601 |
2016 |
|
rs6443930
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analyses of OCD sub-phenotypes demonstrated significant associations between rs3758987 and early onset OCD in male subjects (OR = 0.49, CI = 0.31-0.79, P = 0.0031) and among rs6766410, rs6443930, and the cleaning dimension in female subjects (OR = 0.36, CI = 0.18-0.69, P = 0.0016 and OR = 0.47, CI = 0.29-0.79, P = 0.0030, respectively).
|
27616601 |
2016 |
|
rs2097063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When the OCD group and controls were compared, no significant difference was found between COMT -287A/G (rs2097063), 5-HTTLPR I/D polymorphisms, and OCD.
|
25751280 |
2015 |
|
rs1000592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The case-control analyses revealed a nominal significant association of the HTR3D variant rs1000592 (p.H52R) with OCD (p=0.029) which was also evident after combination of the case-control and the trio-results (p=0.024).
|
23928294 |
2014 |
|
rs1000952
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The case-control analyses revealed a nominal significant association of the HTR3D variant rs1000592 (p.H52R) with OCD (p=0.029) which was also evident after combination of the case-control and the trio-results (p=0.024).
|
23928294 |
2014 |