|
rs1000592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The case-control analyses revealed a nominal significant association of the HTR3D variant rs1000592 (p.H52R) with OCD (p=0.029) which was also evident after combination of the case-control and the trio-results (p=0.024).
|
23928294 |
2014 |
|
rs1000952
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The case-control analyses revealed a nominal significant association of the HTR3D variant rs1000592 (p.H52R) with OCD (p=0.029) which was also evident after combination of the case-control and the trio-results (p=0.024).
|
23928294 |
2014 |
|
rs10042486
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We concluded that among the HTR1A polymorphisms, only the association of rs10042486 CT genotype and OCD was statistically significant.
|
30232922 |
2019 |
|
rs10070190
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.
|
23337130 |
2013 |
|
rs10491734
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The present study provided suggestive evidence that the rs10491734 was significantly associated with early-onset OCD in the Han Chinese population.
|
23564280 |
2013 |
|
rs10491734
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This case-control study enrolled 578 obsessive-compulsive disorder (OCD) patients and 649 controls and genotyped rs10491734, rs2228622, rs301430 and rs301443 to replicate association of the SLC1A1 gene with OCD in ethnic Han Chinese.
|
23411042 |
2013 |
|
rs1059004
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The present study is the first to verify the associations of SNPs rs762178, rs1059004, and rs9653711 of the OLIG2 gene with OCD in a Chinese Han population.
|
26271930 |
2015 |
|
rs1059004
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The following 3 single nucleotide polymorphism markers on OLIG2 were associated with the OCD without TD phenotype: rs762178 (minor allele frequency, 35%; P<.001), rs1059004 (minor allele frequency, 44%; P = .005), and rs9653711 (minor allele frequency, 44%; P = .004).
|
17283288 |
2007 |
|
rs11149058
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.
|
25158072 |
2015 |
|
rs11174202
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.
|
30087453 |
2018 |
|
rs1148374
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CDH2 SNP, rs1120154, C-allele carriers were found to be significantly associated with lower risk to develop OCD compared to TT-homozygotes (OR = 0.49; 95% CI: 0.32-0.75; p < 0.001), and rs12605662 G-allele carriers were significantly associated with reduced risk OCD compared to TT-homozygotes (OR = 0.46; 95% CI: 0.30-0.71; p < 0.001), Furthermore, a single haplotype was found to infer an increased risk for OCD diagnosis (*rs8087457-rs1148374: A-T).
|
26093892 |
2016 |
|
rs11583978
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the OCD group, a significant association was observed between earlier age at onset and the A-T-A-T (rs11583978-rs7541937-rs6662980-rs4652867) haplotype compared with the C-G-G-G haplotype.
|
21295225 |
2011 |
|
rs1176744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant difference existed in the genotypic distribution of the HTR3B variant rs1176744 between individuals with OCD and controls (odds ratio [OR] = 0.74, 95% confidence interval [CI] = 0.60-0.91, P = 0.0043).
|
27616601 |
2016 |
|
rs11783752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five SNPs achieved 0.004 (the nominal p-value expected by chance), 3 with empirical significant p-values (rs10070190 (CDH9) p = 1 × 10(-3), rs4825476 (GRIA3) p = 4 × 10(-4), and rs1074815 (TPH2) p = 8 × 10(-4)) and 2 additional polymorphisms showing nominal significance (rs2834070 (OLIG2) p = 2 × 10(-3) and rs11783752 (SCL18A1) p = 3 × 10(-3)), were found to be related to both AN and OCD.
|
23337130 |
2013 |
|
rs11854486
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three SNPs are most strongly associated with OCD: rs11854486 (P = 0.00005 [0.046 after adjustment for multiple tests]; genetic relative risk (GRR) = 11.1 homozygous and 1.6 heterozygous) and rs4625687 [P = 0.00007 (after adjustment = 0.06); GRR = 2.4] on 15q; and rs4387163 (P = 0.0002 (after adjustment = 0.08); GRR = 1.97) on 1q.
|
22095678 |
2012 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C677T and A1298C mutations of 5,10-methylenetetrahydrofolate reductase (MTHFR) have been linked with conditions such as depression, bipolar disorder, and schizophrenia, but there are not clear the relationship between MTHFR polymorphisms and obsessive-compulsive disorder (OCD).
|
30992611 |
2020 |
|
rs12504244
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Examination of the shared genetic basis of anorexia nervosa and obsessive-compulsive disorder.
|
30087453 |
2018 |
|
rs12536521
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Sex differences in the genetic architecture of obsessive-compulsive disorder.
|
30456828 |
2019 |
|
rs12605662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CDH2 SNP, rs1120154, C-allele carriers were found to be significantly associated with lower risk to develop OCD compared to TT-homozygotes (OR = 0.49; 95% CI: 0.32-0.75; p < 0.001), and rs12605662 G-allele carriers were significantly associated with reduced risk OCD compared to TT-homozygotes (OR = 0.46; 95% CI: 0.30-0.71; p < 0.001), Furthermore, a single haplotype was found to infer an increased risk for OCD diagnosis (*rs8087457-rs1148374: A-T).
|
26093892 |
2016 |
|
rs12635725
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Sex differences in the genetic architecture of obsessive-compulsive disorder.
|
30456828 |
2019 |
|
rs1265692223
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The case-control analyses revealed a nominal significant association of the HTR3D variant rs1000592 (p.H52R) with OCD (p=0.029) which was also evident after combination of the case-control and the trio-results (p=0.024).
|
23928294 |
2014 |
|
rs12682807
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Secondary analyses of male-affecteds only (N = 358 trios and 133 cases) demonstrated modest association between OCD and a different SNP (rs12682807; uncorrected P = 0.012; non-significant corrected P).
|
23606572 |
2013 |
|
rs13046814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A 5-marker haplotype (A/C/T/T/G) constituting these single nucleotide polymorphisms and exonic single nucleotide polymorphisms rs6517137 and rs13046814 was undertransmitted (frequency, 32%; permuted P=.004), whereas the G/A/T/T/C haplotype (frequency, 22%; permuted P=.02) was overtransmitted to probands with OCD alone, with a significant global P value (permuted P=.008).
|
17283288 |
2007 |
|
rs13316193
|
|
|
0.010 |
GeneticVariation |
BEFREE |
While OXTR variants were not associated with the affected status of OCD or its clinical symptom dimensions, rs2268493 (p=0.00185) and rs13316193 (p=0.00461) of the OXTR gene were associated with the age at onset in patients with OCD.
|
28915380 |
2017 |
|
rs1417182
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, the two marker haplotype rs1556995/rs1417182, was significantly associated with OCD (P= 0.0019, permuted P-value = 0.01).
|
20370803 |
2011 |