|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The examined genes and single-nucleotide polymorphisms were 1) TMPRSS6, involved in regulation of hepcidin: rs855791; 2) HFE, associated with hemochromatosis: rs1800562 and rs1799945; 3) BTBD9, associated with restless leg syndrome: rs9357271; and 4) TF, encoding transferrin: rs2280673 and rs1830084.
|
30536387 |
2019 |
|
rs2229940
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest association between GABRR3rs832032 polymorphism and the risk for RLS, and a modifier effect of GABRA4 rs2229940 on the age of onset of RLS.
|
29720720 |
2018 |
|
rs3810651
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied the genotype and allelic variant frequencies of the most common SNPs in the GABRR1(rs12200969, rs1186902), GABRR2(rs282129), GABRR3(rs832032), GABRA4(rs2229940), GABRE(rs1139916), and GABRQ(rs3810651) genes in 205 RLS patients and 230 age- and gender-matched healthy controls using specific TaqMan assays.
|
29720720 |
2018 |
|
rs4784226
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two case-control cohorts including 644 PD patients, 457 RLS patients, and 945 controls were genotyped for one known RLS-related SNP (rs3104767) and one PD-related SNP (rs4784226) in the TOX3 locus.
|
29404899 |
2018 |
|
rs11558538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest a lack of major association between HNMT rs11558538 SNP and the risk for RLS.
|
27837280 |
2017 |
|
rs1229984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest an association between rs1229984 SNP and the risk for RLS.
|
29045753 |
2017 |
|
rs1918752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the initial GWA study of RLS, we observed an association of rs11645604 (OR=1.531, p=1.18×10<sup>-6</sup>) in <i>MPHOSPH6</i> on chromosome 16q23.3, rs1918752 (OR=0.6582, p=1.93×10<sup>-6</sup>) and rs9390170 (OR=0.6778, p=7.67×10<sup>-6</sup>) in <i>UTRN</i> on chromosome 6q24.
|
29209388 |
2017 |
|
rs9390170
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From our sequential GWA and replication study, we could hypothesize rs9390170 polymorphism in <i>UTRN</i> is a novel genetic marker for susceptibility to RLS.
|
29209388 |
2017 |
|
rs179945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The effect of six single-nucleotide polymorphisms (SNPs) on ferritin levels in 14,126 blood donors were investigated in four genes: in Human Hemochromatosis Protein gene (HFE; rs1800562 and rs179945); in Transmembrane Protease gene, Serine 6 (TMPRSS6-regulating hepcidin; rs855791); in BTB domain containing protein gene (BTBD9-associated with restless legs syndrome; rs9357271); and in the Transferrin gene (TF; rs2280673 and rs1830084).
|
26597663 |
2016 |
|
rs2228570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed the possible relationship of 2 common single nucleotide polymorphisms (SNPs) in the vitamin D3 receptor (VDR) gene with the risk for RLS.We studied the genotype and allelic variant frequencies of VDR rs2228570 and VDR rs731236 SNPs in 205 RLS patients and 445 healthy controls using a TaqMan essay.The frequencies of the rs731236AA genotype and the allelic variant rs731236A were significantly lower in RLS patients than in controls (P < 0.005 and < 0.01, respectively).
|
26632733 |
2015 |
|
rs4746
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GLO1 p.E111A variant was associated with RLS in the French-Canadian cohort (odds ratio, OR = 1.38, p = 0.02), and demonstrated a similar trend in the US cohort (OR = 1.26, p = 0.09, combined analysis OR = 1.28, p = 0.009).
|
26298793 |
2015 |
|
rs693534
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs7977109 and rs693534 genotypes and allelic frequencies did not significantly differ between patients with RLS and controls and were unrelated with the age at onset of RLS, gender, ferritin levels, and response to dopaminergic or gabaergic agents.
|
25300364 |
2015 |
|
rs7977109
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs7977109 and rs693534 genotypes and allelic frequencies did not significantly differ between patients with RLS and controls and were unrelated with the age at onset of RLS, gender, ferritin levels, and response to dopaminergic or gabaergic agents.
|
25300364 |
2015 |
|
rs1143633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Controlling for race, gender, and hemoglobin, carrying two copies of the minor allele for IL1B rs1143643, rs1143634, or rs1143633 or carrying the minor allele for IL17A rs8193036 was associated with increased likelihood of meeting RLS diagnostic criteria.
|
23460603 |
2014 |
|
rs1143634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Controlling for race, gender, and hemoglobin, carrying two copies of the minor allele for IL1B rs1143643, rs1143634, or rs1143633 or carrying the minor allele for IL17A rs8193036 was associated with increased likelihood of meeting RLS diagnostic criteria.
|
23460603 |
2014 |
|
rs1801260
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Distribution of CLOCK haplotypes (rs2412646-rs1801260) was significantly different between schizophrenic patients with and without RLS (p = 0.021).
|
24824748 |
2014 |
|
rs2412646
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Distribution of CLOCK haplotypes (rs2412646-rs1801260) was significantly different between schizophrenic patients with and without RLS (p = 0.021).
|
24824748 |
2014 |
|
rs3794087
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of our study suggest that the rs3794087 polymorphism is not related to the risk for RLS.
|
24424098 |
2014 |
|
rs41305272
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology.
|
24436253 |
2014 |
|
rs8193036
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Controlling for race, gender, and hemoglobin, carrying two copies of the minor allele for IL1B rs1143643, rs1143634, or rs1143633 or carrying the minor allele for IL17A rs8193036 was associated with increased likelihood of meeting RLS diagnostic criteria.
|
23460603 |
2014 |
|
rs1052553
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of the present study suggest that the SNP rs1052553</span> is not related with the risk for RLS.
|
23001634 |
2013 |
|
rs1800652
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Especially, rs1800652 (C282Y) in the HFE gene did not associate with RLS.
|
22929029 |
2013 |
|
rs138915427
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rare D1639 allele did not co-segregate with RLS in the family, suggesting that p.E1639D variant is not a causative mutation.
|
21264940 |
2011 |
|
rs371856018
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MPZ mutation His39Pro may be associated with acute-onset neuropathy, early-onset hearing loss and restless legs.
|
16844954 |
2006 |
|
rs1830084
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The examined genes and single-nucleotide polymorphisms were 1) TMPRSS6, involved in regulation of hepcidin: rs855791; 2) HFE, associated with hemochromatosis: rs1800562 and rs1799945; 3) BTBD9, associated with restless leg syndrome: rs9357271; and 4) TF, encoding transferrin: rs2280673 and rs1830084.
|
30536387 |
2019 |