|
rs6747972
|
|
A |
0.810 |
GeneticVariation |
GWASDB |
Herein, we identified six RLS susceptibility loci of genome-wide significance, two of them novel: an intergenic region on chromosome 2p14 (rs6747972, P = 9.03 × 10(-11), OR = 1.23) and a locus on 16q12.1 (rs3104767, P = 9.4 × 10(-19), OR = 1.35) in a linkage disequilibrium block of 140 kb containing the 5'-end of TOX3 and the adjacent non-coding RNA BC034767.
|
21779176 |
2011 |
|
rs6747972
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Herein, we identified six RLS susceptibility loci of genome-wide significance, two of them novel: an intergenic region on chromosome 2p14 (rs6747972, P = 9.03 × 10(-11), OR = 1.23) and a locus on 16q12.1 (rs3104767, P = 9.4 × 10(-19), OR = 1.35) in a linkage disequilibrium block of 140 kb containing the 5'-end of TOX3 and the adjacent non-coding RNA BC034767.
|
21779176 |
2011 |
|
rs6747972
|
|
A |
0.810 |
GeneticVariation |
GWASCAT |
Herein, we identified six RLS susceptibility loci of genome-wide significance, two of them novel: an intergenic region on chromosome 2p14 (rs6747972, P = 9.03 × 10(-11), OR = 1.23) and a locus on 16q12.1 (rs3104767, P = 9.4 × 10(-19), OR = 1.35) in a linkage disequilibrium block of 140 kb containing the 5'-end of TOX3 and the adjacent non-coding RNA BC034767.
|
21779176 |
2011 |
|
rs6494696
|
|
|
0.710 |
GeneticVariation |
GWASDB |
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
|
17637780 |
2007 |
|
rs6494696
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Our study found that one SNP increased the risk of RLS in Chinese population: rs6494696 of MAP2K5/SKOR1 (odds ratio [OR] = 0.09, p < .0001, recessive model).
|
28329290 |
2017 |
|
rs10208712
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.
|
29029846 |
2017 |
|
rs111652004
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.
|
29029846 |
2017 |
|
rs12046503
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.
|
29029846 |
2017 |
|
rs1820989
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.
|
29029846 |
2017 |
|
rs1848460
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.
|
29029846 |
2017 |
|
rs1983167
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
|
17637780 |
2007 |
|
rs340561
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.
|
29029846 |
2017 |
|
rs7881785
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
|
17637780 |
2007 |
|
rs996064
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.
|
29029846 |
2017 |
|
rs1229984
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest an association between rs1229984 SNP and the risk for RLS.
|
29045753 |
2017 |
|
rs179945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The effect of six single-nucleotide polymorphisms (SNPs) on ferritin levels in 14,126 blood donors were investigated in four genes: in Human Hemochromatosis Protein gene (HFE; rs1800562 and rs179945); in Transmembrane Protease gene, Serine 6 (TMPRSS6-regulating hepcidin; rs855791); in BTB domain containing protein gene (BTBD9-associated with restless legs syndrome; rs9357271); and in the Transferrin gene (TF; rs2280673 and rs1830084).
|
26597663 |
2016 |
|
rs9357271
|
|
|
0.880 |
GeneticVariation |
GWASDB |
A genetic risk factor for periodic limb movements in sleep.
|
17634447 |
2007 |
|
rs9357271
|
|
|
0.880 |
GeneticVariation |
BEFREE |
A further meta-analysis of RLS in Asian population found that two SNPs of BTBD9 increased the risk of RLS: rs9296249 of BTBD9 (OR = 1.44, p = .000, T allele), rs9357271 of BTBD9 (OR = 1.38, p = .021, dominant model).
|
28329290 |
2017 |
|
rs9357271
|
|
|
0.880 |
GeneticVariation |
BEFREE |
However, the original genome-wide association study (GWAS) marker, BTBD9 rs9357271, had stronger association with RLS (OR = 1.84, p = 0.0003).
|
26298793 |
2015 |
|
rs9357271
|
|
|
0.880 |
GeneticVariation |
BEFREE |
There was a significant difference in the allele frequency (χ(2) = 8.14, p = 0.004) of the rs9357271 polymorphism between schizophrenic patients with and without RLS symptoms.
|
23361623 |
2013 |
|
rs9357271
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Moreover, we found the haplotype polymorphisms of rs9357271, rs3923809, and rs9296249 (overall p=5.69×10<sup>-18</sup>) in <i>BTBD9</i> was associated with RLS.
|
29209388 |
2017 |
|
rs9357271
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The examined genes and single-nucleotide polymorphisms were 1) TMPRSS6, involved in regulation of hepcidin: rs855791; 2) HFE, associated with hemochromatosis: rs1800562 and rs1799945; 3) BTBD9, associated with restless leg syndrome: rs9357271; and 4) TF, encoding transferrin: rs2280673 and rs1830084.
|
30536387 |
2019 |
|
rs9357271
|
|
|
0.880 |
GeneticVariation |
GWASDB |
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
|
17637780 |
2007 |
|
rs9357271
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The study provided 3 single-nucleotide polymorphisms within BTBD9 associated with TS (chi(2) = 8.02 [P = .005] for rs9357271), with the risk alleles for restless legs syndrome and periodic limb movements during sleep overrepresented in the TS cohort.
|
19822783 |
2009 |
|
rs9357271
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The effect of six single-nucleotide polymorphisms (SNPs) on ferritin levels in 14,126 blood donors were investigated in four genes: in Human Hemochromatosis Protein gene (HFE; rs1800562 and rs179945); in Transmembrane Protease gene, Serine 6 (TMPRSS6-regulating hepcidin; rs855791); in BTB domain containing protein gene (BTBD9-associated with restless legs syndrome; rs9357271); and in the Transferrin gene (TF; rs2280673 and rs1830084).
|
26597663 |
2016 |