Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10208712
rs10208712 		A 0.700 GeneticVariation GWASCAT Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 29029846

2017
dbSNP: rs1026732
rs1026732
MAP2K5
0.720 GeneticVariation GWASDB Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780

2007
dbSNP: rs1026732
rs1026732
MAP2K5
0.720 GeneticVariation BEFREE However, the haplotype analysis showed that the G-G-G-G-T (rs1026732-rs11635424-rs12593813-rs4489954-rs3784709) haplotype was associated with RLS symptoms (permutation p=0.033). 29422930

2018
dbSNP: rs1026732
rs1026732
MAP2K5
0.720 GeneticVariation BEFREE Case-control association studies showed significant association between all three variants and RLS (P=0.0001/OR=1.65, P=0.0021/OR=1.59, and P=0.0011/OR=1.55 for rs2300478, rs9357271, and rs1026732, respectively). 21925394

2011
dbSNP: rs1052553
rs1052553
MAPT
0.010 GeneticVariation BEFREE The results of the present study suggest that the SNP rs1052553</span> is not related with the risk for RLS. 23001634

2013
dbSNP: rs10952927
rs10952927
LOC107986816
G 0.700 GeneticVariation GWASCAT Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 29029846

2017
dbSNP: rs111652004
rs111652004 		G 0.700 GeneticVariation GWASCAT Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 29029846

2017
dbSNP: rs113851554
rs113851554
MEIS1
T 0.700 GeneticVariation GWASCAT Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 29029846

2017
dbSNP: rs1143633
rs1143633
IL1B
0.010 GeneticVariation BEFREE Controlling for race, gender, and hemoglobin, carrying two copies of the minor allele for IL1B rs1143643, rs1143634, or rs1143633 or carrying the minor allele for IL17A rs8193036 was associated with increased likelihood of meeting RLS diagnostic criteria. 23460603

2014
dbSNP: rs1143634
rs1143634
IL1B
0.010 GeneticVariation BEFREE Controlling for race, gender, and hemoglobin, carrying two copies of the minor allele for IL1B rs1143643, rs1143634, or rs1143633 or carrying the minor allele for IL17A rs8193036 was associated with increased likelihood of meeting RLS diagnostic criteria. 23460603

2014
dbSNP: rs11558538
rs11558538
HNMT ; LOC107985948
0.010 GeneticVariation BEFREE These results suggest a lack of major association between HNMT rs11558538 SNP and the risk for RLS. 27837280

2017
dbSNP: rs11635424
rs11635424
MAP2K5
0.710 GeneticVariation GWASDB Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780

2007
dbSNP: rs11635424
rs11635424
MAP2K5
0.710 GeneticVariation BEFREE However, the haplotype analysis showed that the G-G-G-G-T (rs1026732-rs11635424-rs12593813-rs4489954-rs3784709) haplotype was associated with RLS symptoms (permutation p=0.033). 29422930

2018
dbSNP: rs12046503
rs12046503 		C 0.700 GeneticVariation GWASCAT Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 29029846

2017
dbSNP: rs1229984
rs1229984
ADH1B
0.010 GeneticVariation BEFREE These results suggest an association between rs1229984 SNP and the risk for RLS. 29045753

2017
dbSNP: rs12450895
rs12450895
LINC02086
A 0.700 GeneticVariation GWASCAT Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 29029846

2017
dbSNP: rs12469063
rs12469063
MEIS1
0.700 GeneticVariation GWASDB Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780

2007
dbSNP: rs12593813
rs12593813
MAP2K5
0.810 GeneticVariation BEFREE However, the haplotype analysis showed that the G-G-G-G-T (rs1026732-rs11635424-rs12593813-rs4489954-rs3784709) haplotype was associated with RLS symptoms (permutation p=0.033). 29422930

2018
dbSNP: rs12593813
rs12593813
MAP2K5
G 0.810 GeneticVariation GWASCAT Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780

2007
dbSNP: rs12593813
rs12593813
MAP2K5
G 0.810 GeneticVariation GWASDB Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. 21779176

2011
dbSNP: rs12593813
rs12593813
MAP2K5
G 0.810 GeneticVariation GWASDB Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780

2007
dbSNP: rs12593813
rs12593813
MAP2K5
G 0.810 GeneticVariation GWASCAT Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. 21779176

2011
dbSNP: rs12962305
rs12962305
LINC01478
T 0.700 GeneticVariation GWASCAT Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 29029846

2017
dbSNP: rs138915427
rs138915427
PTPRD
0.010 GeneticVariation BEFREE The rare D1639 allele did not co-segregate with RLS in the family, suggesting that p.E1639D variant is not a causative mutation. 21264940

2011
dbSNP: rs17636328
rs17636328
LINC02520
A 0.700 GeneticVariation GWASCAT Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 29029846

2017