Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4626664
rs4626664
PTPRD
0.820 GeneticVariation BEFREE A family-based sibling transmission disequilibrium test showed association of RLS with SNP rs1975197 (P = 0.015), but not with rs4626664 (P = 0.622). 21264940

2011
dbSNP: rs9296249
rs9296249
BTBD9
0.820 GeneticVariation BEFREE A further meta-analysis of RLS in Asian population found that two SNPs of BTBD9 increased the risk of RLS: rs9296249 of BTBD9 (OR = 1.44, p = .000, T allele), rs9357271 of BTBD9 (OR = 1.38, p = .021, dominant model). 28329290

2017
dbSNP: rs9357271
rs9357271
BTBD9
0.880 GeneticVariation BEFREE A further meta-analysis of RLS in Asian population found that two SNPs of BTBD9 increased the risk of RLS: rs9296249 of BTBD9 (OR = 1.44, p = .000, T allele), rs9357271 of BTBD9 (OR = 1.38, p = .021, dominant model). 28329290

2017
dbSNP: rs9357271
rs9357271
BTBD9
0.880 GeneticVariation GWASDB A genetic risk factor for periodic limb movements in sleep. 17634447

2007
dbSNP: rs3923809
rs3923809
BTBD9
A 0.820 GeneticVariation GWASCAT A genetic risk factor for periodic limb movements in sleep. 17634447

2007
dbSNP: rs3923809
rs3923809
BTBD9
A 0.820 GeneticVariation GWASDB A genetic risk factor for periodic limb movements in sleep. 17634447

2007
dbSNP: rs6904723
rs6904723
BTBD9
0.700 GeneticVariation GWASDB A genetic risk factor for periodic limb movements in sleep. 17634447

2007
dbSNP: rs6923737
rs6923737
BTBD9
0.700 GeneticVariation GWASDB A genetic risk factor for periodic limb movements in sleep. 17634447

2007
dbSNP: rs4626664
rs4626664
PTPRD
0.820 GeneticVariation BEFREE A modest association between the PTPRD variant rs4626664 and uremic RLS (odds ratio 1.52, 95% CI 1.03-2.23, P = 0.03) and a trend that TOX3/BC034767 variant rs3104767 may associate with the occurrence of RLS were observed in our dialysis population (odds ratio 1.74, 95% CI 0.97-3.11, P = 0.06). 24433515

2014
dbSNP: rs3104767
rs3104767
CASC16
0.840 GeneticVariation BEFREE A modest association between the PTPRD variant rs4626664 and uremic RLS (odds ratio 1.52, 95% CI 1.03-2.23, P = 0.03) and a trend that TOX3/BC034767 variant rs3104767 may associate with the occurrence of RLS were observed in our dialysis population (odds ratio 1.74, 95% CI 0.97-3.11, P = 0.06). 24433515

2014
dbSNP: rs3104767
rs3104767
CASC16
0.840 GeneticVariation BEFREE A nominal association was observed for homozygous carriers of the rs3104767</span> SNP in PD (OR 1.62, 95% CI 1.05-2.54, p = 0.034), i.e., with an opposite direction of effect on RLS and PD, but this was not significant after Bonferroni correction. 29404899

2018
dbSNP: rs41305272
rs41305272
MAP2K5
0.010 GeneticVariation BEFREE A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology. 24436253

2014
dbSNP: rs1975197
rs1975197
PTPRD
0.810 GeneticVariation BEFREE Both family-based and population-based association studies suggest that PTPRD variant rs1975197 confers risk of RLS. 21264940

2011
dbSNP: rs2300478
rs2300478
MEIS1
0.820 GeneticVariation BEFREE Case-control association studies showed significant association between all three variants and RLS (P=0.0001/OR=1.65, P=0.0021/OR=1.59, and P=0.0011/OR=1.55 for rs2300478, rs9357271, and rs1026732, respectively). 21925394

2011
dbSNP: rs9357271
rs9357271
BTBD9
0.880 GeneticVariation BEFREE Case-control association studies showed significant association between all three variants and RLS (P=0.0001/OR=1.65, P=0.0021/OR=1.59, and P=0.0011/OR=1.55 for rs2300478, rs9357271, and rs1026732, respectively). 21925394

2011
dbSNP: rs1026732
rs1026732
MAP2K5
0.720 GeneticVariation BEFREE Case-control association studies showed significant association between all three variants and RLS (P=0.0001/OR=1.65, P=0.0021/OR=1.59, and P=0.0011/OR=1.55 for rs2300478, rs9357271, and rs1026732, respectively). 21925394

2011
dbSNP: rs1143634
rs1143634
IL1B
0.010 GeneticVariation BEFREE Controlling for race, gender, and hemoglobin, carrying two copies of the minor allele for IL1B rs1143643, rs1143634, or rs1143633 or carrying the minor allele for IL17A rs8193036 was associated with increased likelihood of meeting RLS diagnostic criteria. 23460603

2014
dbSNP: rs1143633
rs1143633
IL1B
0.010 GeneticVariation BEFREE Controlling for race, gender, and hemoglobin, carrying two copies of the minor allele for IL1B rs1143643, rs1143634, or rs1143633 or carrying the minor allele for IL17A rs8193036 was associated with increased likelihood of meeting RLS diagnostic criteria. 23460603

2014
dbSNP: rs8193036
rs8193036
IL17A
0.010 GeneticVariation BEFREE Controlling for race, gender, and hemoglobin, carrying two copies of the minor allele for IL1B rs1143643, rs1143634, or rs1143633 or carrying the minor allele for IL17A rs8193036 was associated with increased likelihood of meeting RLS diagnostic criteria. 23460603

2014
dbSNP: rs2071746
rs2071746
HMOX1
0.020 GeneticVariation BEFREE Despite results of several recent case-control association studies which have suggested a possible contribution of heme-oxygenase 1 (HMOX1) rs2071746 and vitamin D3 receptor (VDR) rs731236 variants, or the presence of allele 2 of the complex microsatellite repeat Rep1 within the alpha-synuclein (SNCA) gene promoter in modifying the risk for RLS, these studies need to be replicated in further studies involving different populations. 29033051

2018
dbSNP: rs731236
rs731236
VDR
0.030 GeneticVariation BEFREE Despite results of several recent case-control association studies which have suggested a possible contribution of heme-oxygenase 1 (HMOX1) rs2071746 and vitamin D3 receptor (VDR) rs731236 variants, or the presence of allele 2 of the complex microsatellite repeat Rep1 within the alpha-synuclein (SNCA) gene promoter in modifying the risk for RLS, these studies need to be replicated in further studies involving different populations. 29033051

2018
dbSNP: rs2412646
rs2412646
CLOCK ; TMEM165
0.010 GeneticVariation BEFREE Distribution of CLOCK haplotypes (rs2412646-rs1801260) was significantly different between schizophrenic patients with and without RLS (p = 0.021). 24824748

2014
dbSNP: rs1801260
rs1801260
CLOCK ; TMEM165
0.010 GeneticVariation BEFREE Distribution of CLOCK haplotypes (rs2412646-rs1801260) was significantly different between schizophrenic patients with and without RLS (p = 0.021). 24824748

2014
dbSNP: rs1800652
rs1800652
FXN
0.010 GeneticVariation BEFREE Especially, rs1800652 (C282Y) in the HFE gene did not associate with RLS. 22929029

2013
dbSNP: rs1800562
rs1800562
HFE ; LOC108783645
0.030 GeneticVariation BEFREE Especially, rs1800652 (C282Y) in the HFE gene did not associate with RLS. 22929029

2013