|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Unfortunately, these studies have produced conflicting results.In a previous report, Shifman et al. found a three-marker haplotype (rs737865-rs4680-rs165599) that showed significant association with schizophrenia.
|
17427186 |
2007 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To assess the genetic contribution of other COMT variants to SZ susceptibility, we investigated three single-nucleotide polymorphisms (SNPs) (rs737865, rs4633, rs165599) in addition to the Val/Met variant (rs4680) in a highly selected sample of Australian Caucasian families containing 107 patients with SZ.
|
15505638 |
2005 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia; more excitingly, we find that P50 might be influenced by COMT rs737865 polymorphisms and PPI may be influenced by COMT rs165599 polymorphisms in schizophrenia, and their mutations are associated with the reduction of the risk of P50 or PPI defects in schizophrenia.
|
23598060 |
2013 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found a significant association of rs737865, with the GG genotype exerting a protective effect and the GA haplotype (rs4680/rs165599) exerting a risk effect for schizophrenia.
|
28273278 |
2017 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To assess this view, the authors conducted a case-control association study (399 patients with schizophrenia and 440 control subjects) for five functional polymorphisms (rs2075507, rs737865, rs6267, rs4680 and rs165599) in Japanese subjects.
|
17482701 |
2007 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Using the NIMH sibling study (SS), a non-independent case-control set, and an independent German (G) case-control set, we performed conditional/unconditional logistic regression to test for epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes.
|
17006672 |
2007 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNP rs165599, which has been mapped to the 3'-UTR region of the COMT gene, was significantly associated with schizophrenia in our family study, and possibly associated with the age of onset, delusion/hallucination symptom dimension, and CPT performance.
|
19369177 |
2009 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this updated meta-analysis, no evidence was found for an association between Val108/158Met polymorphisms, rs6267, rs165599, and haplotypes (rs7378655-rs4680-rs165599) and schizophrenia, although rs2075507 and rs737865 showed trends for significance in allele-wise analyses (P=0.039 in a multiplicative model, P=0.025 in a recessive model for rs2075507, P=0.018 in a dominant model for rs737865, uncorrected).
|
19329282 |
2009 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, in the sample studied, there was no evidence of any association between schizophrenia and rs165599 (A/G) polymorphism in the non-coding region 3' of the COMT gene.
|
23295417 |
2012 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstream SNP (dbSNP rs165599).
|
15098000 |
2004 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The COMT gene rs165599 SNP does not appear to be a single-risk factor for schizophrenia.
|
30165727 |
2018 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of SNP rs4680 with schizophrenia did not remain significant after adjusting for multiple testing.
|
19290789 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, we analyzed the interaction between pharmacological treatment (clozapine vs typical/atypical D2 blockers) and COMT rs4680 polymorphism on cognitive changes after cognitive remediation therapy, in a sample of 98 clinically stabilized patients with schizophrenia.
|
24656901 |
2014 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the V158M SNP of the COMT gene is not associated with TD in schizophrenia.
|
18424907 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val158Met catechol-O-methyl transferase functional polymorphism has been repeatedly associated to differences in performing the Wisconsin Card Sorting Test in both, patients with schizophrenia and healthy individuals.
|
21934644 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the possible epigenetic modulation of the expression of the COMT Val(158)Met polymorphism and consequent effects on cognition and symptoms in schizophrenia, with worse outcomes associated with adverse childhood experiences in Met carriers.
|
24252819 |
2014 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T and COMT Val158Met interact with CA to increase risk of schizophrenia.
|
28556887 |
2017 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant association was observed between schizophrenia, but not other related disorders, and genotypes GG (Val/Val) for rs4680 and TT for rs4633.
|
17363961 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism of the gene coding for catechol-O-methyltransferase (COMT Val(158)Met) is associated with prefrontal-dependent task performance in schizophrenia.
|
16691129 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
COMT val158met polymorphism and molecular alterations in the human dorsolateral prefrontal cortex: Differences in controls and in schizophrenia.
|
27021555 |
2016 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However the Val158Met polymorphism also has disease-specific effects on DLPFC activation in schizophrenia.
|
20398774 |
2010 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia.
|
29559020 |
2018 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, we explored the relationship between the Val158Met polymorphism of the COMT gene and the GMV/cortical thickness/cortical surface area in 150 first-episode treatment-naïve patients with schizophrenia and 100 healthy controls.
|
25564193 |
2015 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Executive control in schizophrenia: a preliminary study on the moderating role of COMT Val158Met for comorbid alcohol and substance use disorders.
|
28635556 |
2017 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found a significant association of the COMT Va</span>l(158)Met polymorphism with schizophrenia</span>.
|
24782165 |
2014 |