|
rs9332377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight SNPs were nominally associated with SZ in either case-control or family based analyses (p < 0.05, rs7631540 and rs2046496 in DRD3; rs363399 and rs10082463 in SLC18A2; rs4680, rs4646315 and rs9332377 in COMT). rs6271 at DBH was associated in both analyses.
|
23932573 |
2013 |
|
rs2020917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs, rs2020917 (OR=0.54, 95% CI 0.37-0.79; P=0.0011) and rs737865 (OR=0.52, 95% CI 0.36-0.74; P=0.0002), in the P2 promoter region were significantly associated with schizophrenia as well as an increase (increase=11.2%, 95% CI 3.7%-19.2%; P=0.0031) in reporter gene expression.
|
22705295 |
2012 |
|
rs165656
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on allele and genotype frequencies in both groups, we found no significant association of DRD3 Ser9Gly polymorphisms and COMT (rs165656) with schizophrenia in Malays.
|
21948748 |
2011 |
|
rs1445081098
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The relationship is examined of the dopamine D2 receptor (DRD2) polymorphism (TaqIA, TaqIB, -141 C Ins/Del) and the catechol-O-methyltransferase (COMT) polymorphism (A-278G, G158A) to the risk of antipsychotic-induced extrapyramidal symptoms (EPS) in schizophrenia and bipolar disorders.
|
18922583 |
2008 |
|
rs755245483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the prevalence of the catechol-O-methyltransferase (COMT) 324G>A (Val108/158Met) and methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphisms in 252 patients with schizophrenia and 405 control subjects.All subjects were of Dutch ancestry.
|
17716874 |
2008 |
|
rs2097603
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using the NIMH sibling study (SS), a non-independent case-control set, and an independent German (G) case-control set, we performed conditional/unconditional logistic regression to test for epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes.
|
17006672 |
2007 |
|
rs165655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The PCR-based restriction fragment length polymorphism (PCR-RFLP) analysis was used to detect three single nucleotide polymorphisms (SNPs), rs165655 (A/G base change) and rs165815 (C/T base change) present in the ARVCF (armadillo repeat gene deletion in velocardiofacial syndrome) locus, and rs756656 (A/C base change) in the LOC128979 (expressed sequence tags, EST) locus, among 100 Chinese family trios consisting of fathers, mothers and affected offspring with schizophrenia.
|
15861775 |
2005 |
|
rs4633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Val/Met and rs4633 variants showed nominally significant associations with SZ (P<0.05), although neither of the individual SNPs remained significant after adjusting for multiple testing (most significant P=0.1174).
|
15505638 |
2005 |
|
rs165688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstream SNP (dbSNP rs165599).
|
15098000 |
2004 |
|
rs4818
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Such associations of <i>COMT</i> rs4680 and rs4818 high-activity (G variants), as well as G-G/G-G haplotype, with the lower risk of TRS in females, but not in males, suggest significant, but sex-specific influence of <i>COMT</i> variants on the development of treatment-resistance in patients with schizophrenia.
|
30018555 |
2018 |
|
rs4818
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We report that the variation in gene sequence at the four COMT SNPs studied was not associated with an altered the risk of schizophrenia but genotype at rs4680 and rs4818, but not rs165519 and rs737865, were associated with varying levels of cortical CHRM1 expression in the human dorsolateral prefrontal cortex (DLPFC).
|
26954460 |
2016 |
|
rs2075507
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this updated meta-analysis, no evidence was found for an association between Val108/158Met polymorphisms, rs6267, rs165599, and haplotypes (rs7378655-rs4680-rs165599) and schizophrenia, although rs2075507 and rs737865 showed trends for significance in allele-wise analyses (P=0.039 in a multiplicative model, P=0.025 in a recessive model for rs2075507, P=0.018 in a dominant model for rs737865, uncorrected).
|
19329282 |
2009 |
|
rs2075507
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To assess this view, the authors conducted a case-control association study (399 patients with schizophrenia and 440 control subjects) for five functional polymorphisms (rs2075507, rs737865, rs6267, rs4680 and rs165599) in Japanese subjects.
|
17482701 |
2007 |
|
rs165774
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Remarkably, alleles of <i>COMT</i> rs165774 (G), <i>DRD2</i> rs6277 (T), and <i>DRD3</i> rs6280 (C) were associated with raised predisposition to schizophrenia (all <i>P</i><0.001).
|
29255361 |
2017 |
|
rs165774
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The second-stage study showed that intronic SNP rs165774 (χ(2) = 8.327, P = 0.0039), CNV6 (χ(2) = 19.66, P = 0.00005), and CNV8 (χ(2) = 16.57, P = 0.00025) were significantly associated with schizophrenia.
|
26852906 |
2016 |
|
rs165774
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Individuals with schizophrenia were more than twice as likely to carry the GG genotype compared to the AA genotype for both the rs165774 and rs4680 SNPs.
|
20934310 |
2012 |
|
rs165774
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Individuals with schizophrenia were more than twice as likely to carry the GG genotype compared to the AA genotype for both the rs165774 and rs4680 SNPs.
|
22208661 |
2011 |
|
rs6267
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Recently, a new functional single-nucleotide polymorphism in the COMT gene, Ala72Ser, was found to be associated with homicidal behavior in schizophrenia, but this finding warrants further replication.
|
21860037 |
2011 |
|
rs6267
|
|
|
0.040 |
GeneticVariation |
BEFREE |
From the six COMT polymorphisms, rs6267 showed an association with the reduced risk of schizophrenia after correction (P(corr) = 0.02).
|
19881467 |
2009 |
|
rs6267
|
|
|
0.040 |
GeneticVariation |
BEFREE |
New functional single nucleotide polymorphism (Ala72Ser) in the COMT gene is associated with aggressive behavior in male schizophrenia.
|
18163386 |
2008 |
|
rs6267
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans.
|
15645182 |
2005 |
|
rs749437638
|
|
|
0.050 |
GeneticVariation |
BEFREE |
MTHFR C677T and COMT Val158Met interact with CA to increase risk of schizophrenia.
|
28556887 |
2017 |
|
rs749437638
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined.
|
22128864 |
2012 |
|
rs749437638
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We examined the prevalence of the catechol-O-methyltransferase (COMT) 324G>A (Val108/158Met) and methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphisms in 252 patients with schizophrenia and 405 control subjects.All subjects were of Dutch ancestry.
|
17716874 |
2008 |
|
rs749437638
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A second polymorphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (rs1801133), has been associated with overall schizophrenia risk and executive function impairment in patients, and may influence dopamine signaling through mechanisms upstream of COMT effects.
|
18988738 |
2008 |