|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Val158Met has been found to predict performance on dopamine-mediated prefrontal tasks in healthy adults and patients with schizophrenia.
|
17924258 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common functional polymorphism (rs4680, Val158Met) has been extensively tested for an association with schizophrenia, but with conflicting results.
|
17482701 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common Val->Met polymorphism (rs4680) in the COMT gene, associated with increased prefrontal dopamine catabolism, impairs prefrontal cognition and might increase risk for schizophrenia.
|
21999147 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A different genomic region composed of three SNPs (rs737865, rs4680, rs165599) within the COMT gene has been reported to be significantly associated with schizophrenia in Ashkenazi Jews.
|
19369177 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined.
|
22128864 |
2012 |
|
rs749437638
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined.
|
22128864 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional polymorphism (Val-158-Met) at the Catechol-O-methyltransferase (COMT) locus has been identified as a potential etiological factor in schizophrenia.
|
16921496 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional polymorphism of the catechol-O-methyltransferase (COMT) gene (Val158Met) partially appears to influence cognitive performance in schizophrenia subjects and healthy controls by modulating prefrontal dopaminergic activity.
|
26255563 |
2015 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of the Val158Met COMT polymorphism and violent behavior in schizophrenia.
|
22905266 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A preliminary study suggested that the COMTVal108/158Met genotype (rs4680) is related to cognitive function in schizophrenia.
|
30326466 |
2019 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstream SNP (dbSNP rs165599).
|
15098000 |
2004 |
|
rs165688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstream SNP (dbSNP rs165599).
|
15098000 |
2004 |
|
rs749437638
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A second polymorphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (rs1801133), has been associated with overall schizophrenia risk and executive function impairment in patients, and may influence dopamine signaling through mechanisms upstream of COMT effects.
|
18988738 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A significant association was observed between schizophrenia, but not other related disorders, and genotypes GG (Val/Val) for rs4680 and TT for rs4633.
|
17363961 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism of the gene coding for catechol-O-methyltransferase (COMT Val(158)Met) is associated with prefrontal-dependent task performance in schizophrenia.
|
16691129 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A valine/methionine polymorphism of the catechol O-methyltransferase gene at amino acid 158 (COMT Val158Met polymorphism) has been identified as a risk factor for cognitive impairment in schizophrenia.
|
16542182 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Accumulating evidence indicates that genetic polymorphisms of D-amino acid oxidase activator (DAOA) (M24; rs1421292; T-allele) and catechol-O-methyltransferase (COMT) (Val¹⁵⁸Met; rs4680) likely enhance susceptibility to schizophrenia.
|
21215384 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Aggression behavior in patients with schizophrenia can be indicated by positive BOLD-fMRI values in the lower CNS and negative values in the high-level CNS and by a recessive gene model in <i>COMT</i> polymorphism rs4680.
|
28223811 |
2017 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Aggression is associated with the 'low' activity allele (Met) of the functional Val158Met polymorphism among people with schizophrenia spectrum disorders relative to the 'high' activity (Val) allele.
|
18075475 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although the etiology of aggression is multifactorial, many studies have associated the Val158Met polymorphism of the COMT with aggression in schizophrenia.
|
21402125 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
As impaired serotonergic and dopaminergic neurotransmission is implicated in the pathogenesis of depression and schizophrenia this study sought to investigate the putative association between several functional gene polymorphisms (SERT 5-HTTLPR, MAO-A VNTR, COMT Val158Met and DAT VNTR) and schizophrenia.
|
28416295 |
2017 |
|
rs6267
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans.
|
15645182 |
2005 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association study of COMT gene Val158Met polymorphism with auditory P300 and performance on neurocognitive tests in patients with schizophrenia and their relatives.
|
17071544 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between COMT Val(158)Met genotype and RTV do not appear to reflect transmission of schizophrenia liability in families.
|
16815691 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Assuming that the published associations found between the exon 4 Val158Met SNP and schizophrenia are due to linkage disequilibrium, these new haplotype data support the hypothesis of a relevant cis variant linked to the rs737865 site, possibly just upstream in the P2 promoter driving transcription of the predominant form of COMT in the brain.
|
15098000 |
2004 |