|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Unfortunately, these studies have produced conflicting results.In a previous report, Shifman et al. found a three-marker haplotype (rs737865-rs4680-rs165599) that showed significant association with schizophrenia.
|
17427186 |
2007 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To assess the genetic contribution of other COMT variants to SZ susceptibility, we investigated three single-nucleotide polymorphisms (SNPs) (rs737865, rs4633, rs165599) in addition to the Val/Met variant (rs4680) in a highly selected sample of Australian Caucasian families containing 107 patients with SZ.
|
15505638 |
2005 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We find that P50 and PPI may be influenced by COMT rs4680 polymorphisms in schizophrenia; more excitingly, we find that P50 might be influenced by COMT rs737865 polymorphisms and PPI may be influenced by COMT rs165599 polymorphisms in schizophrenia, and their mutations are associated with the reduction of the risk of P50 or PPI defects in schizophrenia.
|
23598060 |
2013 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found a significant association of rs737865, with the GG genotype exerting a protective effect and the GA haplotype (rs4680/rs165599) exerting a risk effect for schizophrenia.
|
28273278 |
2017 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To assess this view, the authors conducted a case-control association study (399 patients with schizophrenia and 440 control subjects) for five functional polymorphisms (rs2075507, rs737865, rs6267, rs4680 and rs165599) in Japanese subjects.
|
17482701 |
2007 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Using the NIMH sibling study (SS), a non-independent case-control set, and an independent German (G) case-control set, we performed conditional/unconditional logistic regression to test for epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes.
|
17006672 |
2007 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNP rs165599, which has been mapped to the 3'-UTR region of the COMT gene, was significantly associated with schizophrenia in our family study, and possibly associated with the age of onset, delusion/hallucination symptom dimension, and CPT performance.
|
19369177 |
2009 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this updated meta-analysis, no evidence was found for an association between Val108/158Met polymorphisms, rs6267, rs165599, and haplotypes (rs7378655-rs4680-rs165599) and schizophrenia, although rs2075507 and rs737865 showed trends for significance in allele-wise analyses (P=0.039 in a multiplicative model, P=0.025 in a recessive model for rs2075507, P=0.018 in a dominant model for rs737865, uncorrected).
|
19329282 |
2009 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, in the sample studied, there was no evidence of any association between schizophrenia and rs165599 (A/G) polymorphism in the non-coding region 3' of the COMT gene.
|
23295417 |
2012 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A recent study found, in a large sample of Ashkenazi Jews, a highly significant association between schizophrenia and a particular haplotype of three polymorphic sites in the catechol-O-methyl transferase, COMT, gene: an IVS 1 SNP (dbSNP rs737865), the exon 4 functional SNP (Val158Met, dbSNP rs165688), and a downstream SNP (dbSNP rs165599).
|
15098000 |
2004 |
|
rs165599
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The COMT gene rs165599 SNP does not appear to be a single-risk factor for schizophrenia.
|
30165727 |
2018 |
|
rs749437638
|
|
|
0.050 |
GeneticVariation |
BEFREE |
MTHFR C677T and COMT Val158Met interact with CA to increase risk of schizophrenia.
|
28556887 |
2017 |
|
rs749437638
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We examined the prevalence of the catechol-O-methyltransferase (COMT) 324G>A (Val108/158Met) and methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphisms in 252 patients with schizophrenia and 405 control subjects.All subjects were of Dutch ancestry.
|
17716874 |
2008 |
|
rs749437638
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A second polymorphism, methylenetetrahydrofolate reductase (MTHFR) 677C --> T (rs1801133), has been associated with overall schizophrenia risk and executive function impairment in patients, and may influence dopamine signaling through mechanisms upstream of COMT effects.
|
18988738 |
2008 |
|
rs749437638
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined.
|
22128864 |
2012 |
|
rs749437638
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Interactive effects of COMT Val108/158Met and MTHFR C677T on executive function in schizophrenia.
|
18186041 |
2008 |
|
rs165655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The PCR-based restriction fragment length polymorphism (PCR-RFLP) analysis was used to detect three single nucleotide polymorphisms (SNPs), rs165655 (A/G base change) and rs165815 (C/T base change) present in the ARVCF (armadillo repeat gene deletion in velocardiofacial syndrome) locus, and rs756656 (A/C base change) in the LOC128979 (expressed sequence tags, EST) locus, among 100 Chinese family trios consisting of fathers, mothers and affected offspring with schizophrenia.
|
15861775 |
2005 |
|
rs9332377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight SNPs were nominally associated with SZ in either case-control or family based analyses (p < 0.05, rs7631540 and rs2046496 in DRD3; rs363399 and rs10082463 in SLC18A2; rs4680, rs4646315 and rs9332377 in COMT). rs6271 at DBH was associated in both analyses.
|
23932573 |
2013 |
|
rs165774
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Individuals with schizophrenia were more than twice as likely to carry the GG genotype compared to the AA genotype for both the rs165774 and rs4680 SNPs.
|
20934310 |
2012 |
|
rs165774
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Individuals with schizophrenia were more than twice as likely to carry the GG genotype compared to the AA genotype for both the rs165774 and rs4680 SNPs.
|
22208661 |
2011 |
|
rs165774
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The second-stage study showed that intronic SNP rs165774 (χ(2) = 8.327, P = 0.0039), CNV6 (χ(2) = 19.66, P = 0.00005), and CNV8 (χ(2) = 16.57, P = 0.00025) were significantly associated with schizophrenia.
|
26852906 |
2016 |
|
rs165774
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Remarkably, alleles of <i>COMT</i> rs165774 (G), <i>DRD2</i> rs6277 (T), and <i>DRD3</i> rs6280 (C) were associated with raised predisposition to schizophrenia (all <i>P</i><0.001).
|
29255361 |
2017 |
|
rs165656
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on allele and genotype frequencies in both groups, we found no significant association of DRD3 Ser9Gly polymorphisms and COMT (rs165656) with schizophrenia in Malays.
|
21948748 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of SNP rs4680 with schizophrenia did not remain significant after adjusting for multiple testing.
|
19290789 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study, we analyzed the interaction between pharmacological treatment (clozapine vs typical/atypical D2 blockers) and COMT rs4680 polymorphism on cognitive changes after cognitive remediation therapy, in a sample of 98 clinically stabilized patients with schizophrenia.
|
24656901 |
2014 |