|
rs397507444
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Two common polymorphisms (677C>T and 1298A>C) in the gene coding for MTHFR have been shown to reduce MTHFR enzyme activity and were associated with the susceptibility to different disorders, including vascular disease, neural tube defects and lymphoid malignancies.
|
15921520 |
2005 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To test whether the T variant of the C677T polymorphism in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) would associate with three distinct forms of vascular disease, abdominal aortic aneurysm (AAA), coronary artery disease (CAD) and peripheral vascular disease (PVD).
|
15996600 |
2005 |
|
rs1800458
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Compared with the previously reported case with compound heterozygotes of Glu54Gly and Gly6Ser, the age of onset in our case is much younger and another characteristic findings were the amyloid vasculopathy and the multiple organ involvement.
|
16053476 |
2005 |
|
rs80356814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The LMNA 1908C/T polymorphism plays an important role in the development of cerebral vascular disease and diabetic nephropathy in Japanese men with type 2 diabetes.
|
16117820 |
2005 |
|
rs1061170
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We, therefore, evaluated the CFH genetic variant Y402H amongst 685 Caucasian individuals who subsequently developed arterial or venous thrombotic event (incident myocardial infarction (MI), ischaemic stroke, or venous thromboembolism) and amongst 685 age- and smoking-matched Caucasian individuals who remained free of reported vascular disease during follow-up (controls) within the Physicians' Health Study cohort.
|
16229850 |
2006 |
|
rs34203073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It has been reported that the activating mutation, E133K, in the angiogenic factor VG5Q (formally named AGGF1) causes Klippel-Trenaunay Syndrome (KTS), a rare vascular disease associated with asymmetric overgrowth.
|
16443853 |
2006 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The C677T substitution variant in the methylenetetrahydrofolate reductase (MTHFR) gene has been associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease.
|
16564429 |
2006 |
|
rs749437638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C677T substitution variant in the methylenetetrahydrofolate reductase (MTHFR) gene has been associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease.
|
16564429 |
2006 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygosity for the thermolabile variant of 5,10-methylene tetrahydrofolate reductase (C677T) has been suggested to be positively associated with the risk of vascular disease and neural tube defects.
|
17010581 |
2007 |
|
rs6809699
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we examined the possible association of P2RY12 genetic variants, in particular a haplotype H2 (constituted by dbSNP rs10935838, rs2046934, rs5853517, and rs6809699) amongst 708 white males who subsequently developed a thromboembolic event (incident myocardial infarction (MI), ischemic stroke, or deep venous thromboembolism/pulmonary embolism (DVT/PE)) and amongst an equal number of age- and smoking-matched white males who remained free of reported vascular disease during follow-up (controls).
|
17707382 |
2008 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Mutations or polymorphisms in the gene of the enzyme methylenetetrahydrofolate reductase (MTHFR), as C677T, A1298C and G1793A, are associated with hyperhomocysteinemia and possibly with elevated risk for vascular diseases.
|
17966140 |
2007 |
|
rs397507444
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Mutations or polymorphisms in the gene of the enzyme methylenetetrahydrofolate reductase (MTHFR), as C677T, A1298C and G1793A, are associated with hyperhomocysteinemia and possibly with elevated risk for vascular diseases.
|
17966140 |
2007 |
|
rs11591147
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In this population 3.5% were carriers of the T allele at R46L, and these subjects had significantly (p<0.001) lower levels of LDL C (mean, -10%), no difference in LDL C lowering response to pravastatin, and a non-significant 19% unadjusted and 9% adjusted decreased risk of vascular disease at baseline, with no on trial effect.
|
18262190 |
2008 |
|
rs505151
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, 6.0% were carriers of the G allele at E670G with no significant relationships with baseline LDL C, response to pravastatin, or vascular disease risk being observed.
|
18262190 |
2008 |
|
rs1799983
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The eNOS gene polymorphism at position 894 (G>T, Glu298Asp) resulting in T allele has been studied in the context of vascular diseases, but its role in sepsis has not yet been explored.
|
18827745 |
2009 |
|
rs1801394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we determined total plasma homocysteine levels and MTRR A66G polymorphism in 114 patients with vascular disease: 58 patients with deep-vein thrombosis, 56 patients with arterial thrombosis, and 95 healthy subjects from the Sicilian population.
|
19348062 |
2009 |
|
rs313158
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From a group of DNA samples collected at baseline in a prospective cohort of 14 916 initially healthy American men, we assessed 16 TRPM7 tag-single-nucleotide polymorphisms (SNPs) (dbSNP: rs11854949, rs4775899, rs11635825, rs12905120, rs16973487, rs7173321, rs7163283, rs17520378, rs17520350, rs4775892, rs7174839, rs17645523, rs3109894, rs616256, rs11070795, and rs313158) from 245 white men who subsequently had an incident ischemic stroke and from 245 age- and smoking habit-matched white men who remained free of reported vascular disease during follow-up (controls).
|
19644062 |
2009 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MTHFR 677C/T polymorphism is associated with the risk of vascular diseases due to hyperhomocysteinemia.
|
19646848 |
2009 |
|
rs1333049
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Altogether, our data indicate for the first time that the C allele of rs1333049 in the vascular disease susceptibility locus is associated with VaD and LOAD, independent of traditional risk factors and the APOE ε4 genotype.
|
19664850 |
2011 |
|
rs2144151
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The multipoint linkage peak was located at marker rs2144151 in the ANGPT4 gene, which is a strong candidate gene for vascular disease because of its involvement in angiogenesis.
|
20596041 |
2010 |
|
rs14259
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We then screened 200 T2D siblings/families for PSMD9 +nt460A/G, +nt437C/T and exon E197G A/G single nucleotide polymorphisms (SNPs) and performed a non-parametric linkage study to test for linkage for coronary artery disease, stroke/TIA, macro-vasculopathy and macrovascular pathology of T2D.
|
21496327 |
2011 |
|
rs765798193
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We then screened 200 T2D siblings/families for PSMD9 +nt460A/G, +nt437C/T and exon E197G A/G single nucleotide polymorphisms (SNPs) and performed a non-parametric linkage study to test for linkage for coronary artery disease, stroke/TIA, macro-vasculopathy and macrovascular pathology of T2D.
|
21496327 |
2011 |
|
rs72653706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygosity for R1141X in ABCC6 and risk of ischemic vascular disease.
|
21831958 |
2011 |
|
rs1799983
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Endothelial nitric oxide synthase (eNOS) G894T polymorphism has been previously associated with vascular diseases including stroke, but often with conflicting results.
|
22004707 |
2011 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Blood samples from 70 patients with vascular disease and 70 healthy controls were analyzed for plasma homocysteine levels (chemiluminescent immunoassay) and for the presence of MTHFR C677T (polymerase chain reaction analysis).
|
22375042 |
2012 |