|
rs2651899
|
|
|
0.880 |
GeneticVariation |
BEFREE |
We report significant influence of rs1835740, LRP1 rs11172113 and PRDM16 rs2651899 polymorphisms on migraine susceptibility in the North Indian population.
|
24266335 |
2014 |
|
rs2651899
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Our major findings suggest that PRDM16 rs2651899 polymorphism is associated with the risk of migraine.
|
31557325 |
2020 |
|
rs2651899
|
|
|
0.880 |
GeneticVariation |
BEFREE |
We identified the minor allele of rs2651899 located in PRDM16 to be associated with migraine (P = .005, odds ratio = 1.382, 95% confidence interval = 1.100-1.736), the association remain significant after Bonferroni correction.
|
24666033 |
2014 |
|
rs2651899
|
|
|
0.880 |
GeneticVariation |
BEFREE |
This research study showed that rs2651899 is a potential genetic marker for migraine susceptibility in MO and female subgroup at both genotypic and allelic level in the North Indian population and found that rs10166942 variant may be a potential marker for MA and male subgroup.
|
30635810 |
2019 |
|
rs2651899
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The meta-analysis confirmed the previous three genome-wide significant associated SNPs (rs2651899, rs10166942 and rs11172113) to confer risk of migraine.
|
23294458 |
2013 |
|
rs2651899
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The potential function of the fourth variant rs2651899 (PRDM16) in migraine is unclear.
|
22072275 |
2012 |
|
rs2651899
|
|
|
0.880 |
GeneticVariation |
BEFREE |
The associations at rs2651899 and rs10166942 were specific for migraine compared with non-migraine headache.
|
21666692 |
2011 |
|
rs2651899
|
|
|
0.880 |
GeneticVariation |
BEFREE |
Our data indicates that rs1835740 and MTDH might be involved in neurovascular headaches in general whilst rs2651899 is specifically related to migraine.
|
30382894 |
2018 |
|
rs10166942
|
|
|
0.870 |
GeneticVariation |
BEFREE |
On the other hand, TRPM8 rs10166942 and TGFBR2 rs7640543 variants did not have significant influence on migraine susceptibility in the North Indian population.
|
24266335 |
2014 |
|
rs10166942
|
|
|
0.870 |
GeneticVariation |
BEFREE |
The associations at rs2651899 and rs10166942 were specific for migraine compared with non-migraine headache.
|
21666692 |
2011 |
|
rs10166942
|
|
|
0.870 |
GeneticVariation |
BEFREE |
We infer strong positive selection, in agreement with ancient DNA showing high frequency of the allele in Europe 3,000 to 8,000 years ago. rs10166942 is important phenotypically because its ancestral allele is protective of migraine.
|
29723195 |
2018 |
|
rs10166942
|
|
|
0.870 |
GeneticVariation |
BEFREE |
To further replicate the GWAS findings, we investigated the 3 variants rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8), and rs11172113 (12q13.3, LRP1) for their association with migraine in the Chinese Han population.
|
24666033 |
2014 |
|
rs10166942
|
|
|
0.870 |
GeneticVariation |
BEFREE |
The meta-analysis confirmed the previous three genome-wide significant associated SNPs (rs2651899, rs101</span>66942 and rs11172113) to confer risk of migraine.
|
23294458 |
2013 |
|
rs10166942
|
|
|
0.870 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies (GWAS) have identified 3 loci in or near PRDM16 (1p36.32, rs2651899), LRP1 (12q13.3, rs11172113) and TRPM8 (2q37.1, rs10166942) in the population-based Women's Genome Health Study (WGHS) of migraine, and 2 loci in or near TRPM8 and LRP1 were repeated in European GWAS study.
|
24021092 |
2014 |
|
rs10166942
|
|
|
0.870 |
GeneticVariation |
BEFREE |
This research study showed that rs2651899 is a potential genetic marker for migraine susceptibility in MO and female subgroup at both genotypic and allelic level in the North Indian population and found that rs10166942 variant may be a potential marker for MA and male subgroup.
|
30635810 |
2019 |
|
rs1835740
|
|
|
0.860 |
GeneticVariation |
BEFREE |
A large two-stage GWAS by Antilla et al. reported the minor allele of rs1835740 on 8q22.1 to be associated with common types of migraine.
|
21964821 |
2012 |
|
rs1835740
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Our data indicates that rs1835740 and MTDH might be involved in neurovascular headaches in general whilst rs2651899 is specifically related to migraine.
|
30382894 |
2018 |
|
rs1835740
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Carriers of the rs1835740 variant showed a non-significant tendency towards having a higher frequency of aura symptoms and a non-significant tendency towards milder migraine headache characteristics and fewer accompanying symptoms.
|
22103325 |
2012 |
|
rs1835740
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Recently, a clinic-based genome-wide association study for migraine reported a functionally relevant risk variant (SNP rs1835740), involved in glutamate homeostasis, which showed a significant association with MA.
|
22908361 |
2012 |
|
rs1835740
|
|
|
0.860 |
GeneticVariation |
BEFREE |
To our knowledge, our data establish rs1835740 as the first genetic risk factor for migraine.
|
20802479 |
2010 |
|
rs1835740
|
|
|
0.860 |
GeneticVariation |
BEFREE |
We report significant influence of rs1835740, LRP1 rs11172113 and PRDM16 rs2651899 polymorphisms on migraine susceptibility in the North Indian population.
|
24266335 |
2014 |
|
rs11172113
|
|
|
0.850 |
GeneticVariation |
BEFREE |
To further check if these variants differ by ethnicity, three single nucleotide polymorphisms (SNPs) (rs4379368, rs10504861and rs11172113) were genotyped here to find association with migraine susceptibility from North Indian population.
|
31505242 |
2019 |
|
rs11172113
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The meta-analysis confirmed the previous three genome-wide significant associated SNPs (rs2651899, rs10166942 and rs11172113</span>) to confer risk of migraine.
|
23294458 |
2013 |
|
rs11172113
|
|
|
0.850 |
GeneticVariation |
BEFREE |
In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P < 5 × 10(-6)) with migraine.
|
21666692 |
2011 |
|
rs11172113
|
|
|
0.850 |
GeneticVariation |
BEFREE |
To further replicate the GWAS findings, we investigated the 3 variants rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8), and rs11172113 (12q13.3, LRP1) for their association with migraine in the Chinese Han population.
|
24666033 |
2014 |