|
rs10803531
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The associations of six SNPs identified from our previous study, including TRPM8 rs10166942, LRP1 rs1172113, DLG2 rs655484, GFRA1 rs3781545, UPP2 rs7565931, and GPR39 rs10803531, and migraine endophenotypes, including chronic migraine and allodynia were tested.
|
31842742 |
2019 |
|
rs140325655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast we find no change in excitability in induced pluripotent stem cell derived nociceptors with the C110R mutation and preserved TRESK current; thereby confirming that only the frameshift mutation is associated with loss of function and a migraine relevant cellular phenotype.
|
31742594 |
2019 |
|
rs2070744
|
|
|
0.010 |
GeneticVariation |
BEFREE |
NOS3 rs2070744 SNP is not associated with the risk for migraine in Caucasian Spanish people although it might be related to family history.
|
31792366 |
2019 |
|
rs1051730
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, there was no association between the rs1051730 T allele and migraine or non-migrainous headache versus no headache.
|
29747220 |
2018 |
|
rs11858956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analysis of results for 8,045,569 SNPs from a migraine GWAS (comprising 30,465 migraine cases and 143,147 control samples) and the top 10,000 SNPs from a MDD GWAS (comprising 75,607 MDD cases and 231,747 healthy controls), implicated three SNPs (rs146377178, rs672931, and rs11858956) with novel genome-wide significant association (P<sub>SNP</sub> ≤ 5 × 10<sup>-8</sup>) to migraine and MDD.
|
29995844 |
2018 |
|
rs1883832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings showed that in CD40 rs1883832, TC genotype may have a role in migraine susceptibility.
|
30511624 |
2018 |
|
rs2971609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These loci were also associated with other cerebral blood flow parameters below genome-wide significance, and rs2971609 lies in a known migraine locus.
|
28627999 |
2018 |
|
rs3765459
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant associations observed between the rs4810485 and rs3765459 SNPs with migraine.
|
30511624 |
2018 |
|
rs41263963
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the study was to analyze, for the first time in the Polish population, the 5-HT transporter linked polymorphic region (5-HTTLPR) in <i>SLC6A4</i>, G1222A (rs2271933) and the never before studied *G29A (rs41263963) polymorphisms in the <i>HCRTR1</i> gene, as well as the 5-HT and hypocretin-1 plasma concentrations in migraine patients (MA, MO) and control subjects.
|
29922128 |
2018 |
|
rs4810485
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant associations observed between the rs4810485 and rs3765459 SNPs with migraine.
|
30511624 |
2018 |
|
rs4846049
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Present data provide evidence for the association of rs4846049 and C677T polymorphisms in the MTHFR gene and migraine.
|
29379315 |
2018 |
|
rs672931
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Meta-analysis of results for 8,045,569 SNPs from a migraine GWAS (comprising 30,465 migraine cases and 143,147 control samples) and the top 10,000 SNPs from a MDD GWAS (comprising 75,607 MDD cases and 231,747 healthy controls), implicated three SNPs (rs146377178, rs672931, and rs11858956) with novel genome-wide significant association (P<sub>SNP</sub> ≤ 5 × 10<sup>-8</sup>) to migraine and MDD.
|
29995844 |
2018 |
|
rs11558538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This suggests that mutant alleles of C314T for HNMT and C2029G for DAO polymorphisms may interact in a way that increases the risk and impact of migraine.
|
27130307 |
2017 |
|
rs1186902
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most common polymorphisms in the GABRR genes seemed to be not associated with the risk for migraine in Caucasian Spanish people, although one of them (GABRR1 rs1186902) shows a statistically significant association with the age of onset of migraine.
|
28699326 |
2017 |
|
rs2023239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, AG and GG genotypes of OPRM1 rs1799971 were correlated with migraine episodes, AG and GG of OPRM1 rs1799971, and CT and CC of CNR1 rs806368 with a family history of migraines (second degree relatives), and CT and CC of CNR1 rs2023239 with a positive response to therapy.
|
28349993 |
2017 |
|
rs35737760
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Asp859Glu - rs35737760 SNP of the CACNA1E gene was present in 12.7% of control subjects and in 20.4% of the total migraine group.
|
28573794 |
2017 |
|
rs806368
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, AG and GG genotypes of OPRM1 rs1799971 were correlated with migraine episodes, AG and GG of OPRM1 rs1799971, and CT and CC of CNR1 rs806368 with a family history of migraines (second degree relatives), and CT and CC of CNR1 rs2023239 with a positive response to therapy.
|
28349993 |
2017 |
|
rs832032
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of GABRR1 rs12200969, GABRR1 rs1186902, GABRR2 rs282129, and GABRR3 rs832032 genotypes and allelic variants were studied in a case-control association study involving 197 patients with migraine and 278 healthy controls by means of a TaqMan-based qPCR Assay.
|
28699326 |
2017 |
|
rs9340799
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further haplotypic analysis shows that rs2234693-rs9340799</span> TA haplotype serves as risk</span> haplotype for migraine.
|
27778160 |
2017 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MDR1 C3435T polymorphism was also found to be a higher risk factor for topiramate treatment failure in a comparison of the number of days with migraine (β2=1.152, p=0.015).
|
27288795 |
2016 |
|
rs12355831
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we identified the functional variant (rs2256368:A>G) affecting ACSL5 exon 20 skipping, as a causal factor linked to the migraine-associated rs12355831:A>G, suggesting that the activation of long-chain fatty acids by the spliced ACSL5-Δ20 molecules, a mitochondrial located enzyme, is involved in migraine pathology.
|
27189022 |
2016 |
|
rs2256368
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we identified the functional variant (rs2256368:A>G) affecting ACSL5 exon 20 skipping, as a causal factor linked to the migraine-associated rs12355831:A>G, suggesting that the activation of long-chain fatty acids by the spliced ACSL5-Δ20 molecules, a mitochondrial located enzyme, is involved in migraine pathology.
|
27189022 |
2016 |
|
rs2300478
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate regression analyses further showed that rs2300478 in MEIS1 (OR = 1.39, p = 0.018), a CM diagnosis (OR = 1.52, p = 0.022), and depression (OR = 1.86, p = 0.005) were independent predictors of RLS in migraine.
|
26643377 |
2016 |
|
rs694539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Consequently our results clearly indicate that the NNMT gene rs694539 variant is a genetic risk factor for migraine.
|
27726107 |
2016 |
|
rs10156191
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The DAO SNP rs10156191, which is related to decreased DAO enzyme activity, is associated with the risk of developing migraine, particularly in women.
|
25612138 |
2015 |