Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Migraine and MTHFR C677T genotype in a population-based sample. 16365871

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Migraine mediates the influence of C677T MTHFR genotypes on ischemic stroke risk with a stroke-subtype effect. 17962595

2007

dbSNP: rs752380770
rs752380770
0.010 GeneticVariation BEFREE A280V polymorphism in the histamine H3 receptor as a risk factor for migraine. 21376262

2011

dbSNP: rs3794087
rs3794087
0.010 GeneticVariation BEFREE rs3794087 genotype and allelic variants were not related with the risk for migraine in Caucasian Spanish people. 24412224

2014

dbSNP: rs1835740
rs1835740
0.860 GeneticVariation BEFREE A large two-stage GWAS by Antilla et al. reported the minor allele of rs1835740 on 8q22.1 to be associated with common types of migraine. 21964821

2012

dbSNP: rs867770797
rs867770797
0.030 GeneticVariation BEFREE A recent association study has shown that the biallelic -231 G>A polymorphism of the EDNRA gene is associated to migraine in an elderly population. 16618267

2006

dbSNP: rs758454871
rs758454871
0.010 GeneticVariation BEFREE Also, POLG mutations (eg, p.T851 A, p.N468D, p.Y831C, p.G517V, and p.P163S) can cause disease through impaired replication of mtDNA, including migraine. 24331360

2013

dbSNP: rs5498
rs5498
0.010 GeneticVariation BEFREE Although the independent risk factor constituted by this polymorphism in other ethnic groups requires further study, our studies raise the possibility of the development of ICAM1 K469E E allele-specific therapeutics for the prevention and treatment of migraine in the Chinese Han population. 25145994

2014

dbSNP: rs9566867
rs9566867
0.010 GeneticVariation BEFREE Although the level of significance was significantly reduced when using the Fisher's exact test (as a result of the low count of cases with migraine), rs9566845 P = 1.4 × 10(-5) and rs9566867 P = 1.5 × 10(-5), this region remained the most prominent finding. 20528957

2010

dbSNP: rs3754701
rs3754701
0.010 GeneticVariation BEFREE Although we find no significant association of any of the SNPs tested with migraine overall, we detected a nominally significant association (p=0.031) of the RAMP1 rs3754701 variant in male migraine subjects, although this is non-significant after Bonferroni correction for multiple testing. 23237777

2013

dbSNP: rs11542041
rs11542041
0.010 GeneticVariation BEFREE Altogether, 134 Finnish CADASIL patients with p.Arg133Cys mutation were analysed for possible associations between the apolipoprotein E (APOE) genotype, angiotensinogen (AGT) p.Met268Thr polymorphism or neutral p.Ala202Ala NOTCH3 polymorphism and earlier first-ever stroke or migraine. 25819272

2015

dbSNP: rs137852642
rs137852642
0.010 GeneticVariation BEFREE Altogether, 134 Finnish CADASIL patients with p.Arg133Cys mutation were analysed for possible associations between the apolipoprotein E (APOE) genotype, angiotensinogen (AGT) p.Met268Thr polymorphism or neutral p.Ala202Ala NOTCH3 polymorphism and earlier first-ever stroke or migraine. 25819272

2015

dbSNP: rs699
rs699
AGT
0.020 GeneticVariation BEFREE Altogether, 134 Finnish CADASIL patients with p.Arg133Cys mutation were analysed for possible associations between the apolipoprotein E (APOE) genotype, angiotensinogen (AGT) p.Met268Thr polymorphism or neutral p.Ala202Ala NOTCH3 polymorphism and earlier first-ever stroke or migraine. 25819272

2015

dbSNP: rs1043994
rs1043994
0.020 GeneticVariation BEFREE Altogether, 134 Finnish CADASIL patients with p.Arg133Cys mutation were analysed for possible associations between the apolipoprotein E (APOE) genotype, angiotensinogen (AGT) p.Met268Thr polymorphism or neutral p.Ala202Ala NOTCH3 polymorphism and earlier first-ever stroke or migraine. 25819272

2015

dbSNP: rs745738344
rs745738344
TNF
0.030 GeneticVariation BEFREE Among the ten studies identified, the best evidence is available for the TNFα -308G>A and TNFβ 252A > G polymorphisms indicating no overall association with migraine. 22001640

2011

dbSNP: rs2271933
rs2271933
0.020 GeneticVariation BEFREE An HCRTR1 gene variant (rs2271933 G > A) leading to amino acid substitution (Ile408Val) has been associated with migraine and mood disorders. 30742846

2019

dbSNP: rs6313
rs6313
0.020 GeneticVariation BEFREE Association analysis of 5-HTTLPR variants, 5-HT2a receptor gene 102T/C polymorphism and migraine. 14668201

2004

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis. 17714520

2009

dbSNP: rs397507444
rs397507444
0.050 GeneticVariation BEFREE Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk. 12654508

2003

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Association of von Willebrand factor activity with ACE I/D and MTHFR C677T polymorphisms in migraine. 19298544

2009

dbSNP: rs6790925
rs6790925
0.810 GeneticVariation BEFREE At one extreme, SNPs rs6790925 (near TGFBR2) and rs2274316 (MEF2D) were not associated with migraine overall, MA, or MO but were selective for migraine sub-classified by the presence of one or more of the additional migraine features. 24852292

2014

dbSNP: rs2274316
rs2274316
0.820 GeneticVariation BEFREE At one extreme, SNPs rs6790925 (near TGFBR2) and rs2274316 (MEF2D) were not associated with migraine overall, MA, or MO but were selective for migraine sub-classified by the presence of one or more of the additional migraine features. 24852292

2014

dbSNP: rs712507
rs712507
0.010 GeneticVariation BEFREE BDNF SNPs rs1519480, rs6265, rs712507, and rs12273363 were not significantly associated with migraine. 24708359

2015

dbSNP: rs12273363
rs12273363
0.010 GeneticVariation BEFREE BDNF SNPs rs1519480, rs6265, rs712507, and rs12273363 were not significantly associated with migraine. 24708359

2015

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE BMIs were significantly lower in the control than the migraine group (p = 0.021); however, an association between the C677T variant and BMI was not found (p = 0.787) in the migraine group. 23975093

2013