|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A diagnosis of liver cancer or cirrhosis is rare in the lifetime of individuals from this population who are homozygous for the C282Y mutation (2.5%; upper 95% confidence interval (CI) = 8%).
|
10673304 |
2000 |
|
rs763569821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the frequency of primary liver carcinoma (PLC) with biliary differentiation, such as cholangiocarcinoma (CC) and combined hepatocholangiocarcinoma (CHCC), in GH remains unclear We analyzed the histologic type of 20 PLCs occurring in the background of GH; all patients were homozygotic for the C282Y mutation.
|
11710692 |
2001 |
|
rs1330010954
|
|
|
0.010 |
GeneticVariation |
BEFREE |
With RhoGAP-deficient DLC1 mutant (DLC1-K714E), we showed that the RhoGAP activity was essential for DLC1-mediated tumor suppressor function.
|
16204057 |
2005 |
|
rs372894000
|
|
|
0.010 |
GeneticVariation |
BEFREE |
With RhoGAP-deficient DLC1 mutant (DLC1-K714E), we showed that the RhoGAP activity was essential for DLC1-mediated tumor suppressor function.
|
16204057 |
2005 |
|
rs756966085
|
|
|
0.010 |
GeneticVariation |
BEFREE |
With RhoGAP-deficient DLC1 mutant (DLC1-K714E), we showed that the RhoGAP activity was essential for DLC1-mediated tumor suppressor function.
|
16204057 |
2005 |
|
rs28934575
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The mutation Arg114Gly was predicted bioinformatically to affect Nogo-66 dimensional structure of Nogo-C. Our previous works also had indicated that mutant Nogo-C promoted liver cancer cell line apoptosis and resulted in molecular marker of HCC p53 gene transfer from nucleus to cytoplast.
|
18080785 |
2009 |
|
rs1447295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers.
|
18990762 |
2008 |
|
rs6983267
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also observed a suggestive association between rs6983267 and liver cancer (ORadj, 1.51; 95% CI, 0.99-2.31).
|
18990762 |
2008 |
|
rs16901979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers.
|
18990762 |
2008 |
|
rs28929474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to retrospective studies, up to 25% of those with homozygous ZZ (Glu 342 to Lys) AATD suffer from liver cirrhosis and/or liver cancer in late adulthood.
|
21617532 |
2011 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.
|
22087248 |
2011 |
|
rs4444903
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The epidermal growth factor (EGF) rs4444903 A>G polymorphism has been associated with the development of liver cancer, which commonly complicates cirrhosis of viral origin; however, whether this polymorphism might be associated with fibrosis progression in chronic viral hepatitis is unknown.
|
22122913 |
2012 |
|
rs20576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine if gene variants in the TRAIL receptor I (DR4) gene affect the risk of hepatitis C virus (HCV)-induced liver cancer (HCC), we analysed DR4 mutations C626G (rs20575) and A683C (rs20576) in HCV-infected patients with and without HCC.
|
22401174 |
2012 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These patients were followed-up and screened for the risk of HCC, and the influence of rs738409 on the occurrence of liver cancer was assessed using the Kaplan-Meier method, then according to the multivariate Cox model.
|
23069476 |
2013 |
|
rs3746444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
35, 95% CI: 1.09-1.67), and rs3746444 was associated with liver cancer in the subgroup of cancer types.
|
23725137 |
2013 |
|
rs3734091
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the role of genetic polymorphisms at XRCC4 codon 247 (rs3734091, XRCC4P) and XRCC5 codon 180 (rs80309960, XRCC5P) in liver cancer (hepatocellular carcinoma) caused by aflatoxin B1 (AFB1).
|
23788213 |
2013 |
|
rs80309960
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the role of genetic polymorphisms at XRCC4 codon 247 (rs3734091, XRCC4P) and XRCC5 codon 180 (rs80309960, XRCC5P) in liver cancer (hepatocellular carcinoma) caused by aflatoxin B1 (AFB1).
|
23788213 |
2013 |
|
rs1801131
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, Asian individuals with the homozygote genotype CC of MTHFR rs1801131 polymorphism are significantly associated with decreased risk of liver cancer.
|
24014085 |
2014 |
|
rs397507444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MTHFR rs1801131 (A1298C) polymorphism can decrease in vitro MTHFR enzyme activity and has been hypothesized to be associated with liver cancer risk.
|
24014085 |
2014 |
|
rs1447295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In a dominant model, among those with a family history of cancer, rs1447295 was positively associated with liver cancer (OR(adj) 2.80; 95% CI 1.15-6.80).
|
24030569 |
2014 |
|
rs6983267
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Heterogeneity was observed (P(heterogeneity) = 0.029) with rs6983267 and liver cancer, with positive association in the dominant model among those with a family history of cancer and positive association in the recessive model among those without a family history of cancer.
|
24030569 |
2014 |
|
rs1801133
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Therefore, MTHFR Ala222Val polymorphism is significantly associated with risk of hepatitis infection but not liver cancer</span>.
|
24155211 |
2014 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Variation at rs738409 was not associated with significant changes in resolution rate of hepatitis C. By contrast, M/M genotype, present at higher frequencies (22.8%) in HCC patients than in patients with chronic hepatitis C (8.5%, P = 0.004) or control individuals (9.1%, P = 0.005) was associated with a 3-fold increase of liver cancer risk.
|
24269995 |
2014 |
|
rs230496
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusted for potential confounding factors, rs28362491 ins/del or del/del genotypes were associated with higher risk of liver cancer with an adjusted OR 1.54 (95% CI 1.04 to 2.28). rs230496 AG and GG genotypes were also noted with higher risk of liver cancer with an adjusted OR 1.53 (95% CI 1.03 to 2.26).
|
24578542 |
2014 |
|
rs230525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis indicated that carriers of the NFKB1 GA and AA (rs230525-rs230530) haplotypes had higher risk of liver cancer under an additive model.
|
24578542 |
2014 |