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rs1051861187
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we report the first characterisation at the protein level of six ABCB4 variants (D243A, K435T, G535D, I490T, R545C, and S978P) previously found in patients with inflammatory liver diseases or liver cancer.
|
28220208 |
2017 |
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rs1682111
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027).
|
31124313 |
2019 |
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rs1682111
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population.
|
28978066 |
2017 |
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rs843645
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027).
|
31124313 |
2019 |
|
rs843645
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found that rs6713088 (G allele: odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.07-1.52, <i>P</i> = 0.007; GG vs. CC: OR = 1.49, 95% CI: 1.02-2.1, <i>P</i> = 0.038), rs843711 (T allele: OR = 1.29, 95% CI: 1.09-1.54, <i>P</i> = 0.004; TT vs. CC: OR = 1.62, 95% CI: 1.13-2.31, <i>P</i> = 0.008), rs843706 (A allele: OR = 1.30, 95% CI: 1.09-1.55, <i>P</i> = 0.003; AA vs. CC: OR = 1.62, 95% CI: 1.13-2.31, <i>P</i> = 0.008), and rs843645 (GG vs. AG: OR = 1.40, 95% CI: 1.07-1.82, <i>P</i> = 0.014) were associated with an increased risk of liver cancer.
|
28978066 |
2017 |
|
rs6713088
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs6713088 (G allele: odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.07-1.52, <i>P</i> = 0.007; GG vs. CC: OR = 1.49, 95% CI: 1.02-2.1, <i>P</i> = 0.038), rs843711 (T allele: OR = 1.29, 95% CI: 1.09-1.54, <i>P</i> = 0.004; TT vs. CC: OR = 1.62, 95% CI: 1.13-2.31, <i>P</i> = 0.008), rs843706 (A allele: OR = 1.30, 95% CI: 1.09-1.55, <i>P</i> = 0.003; AA vs. CC: OR = 1.62, 95% CI: 1.13-2.31, <i>P</i> = 0.008), and rs843645 (GG vs. AG: OR = 1.40, 95% CI: 1.07-1.82, <i>P</i> = 0.014) were associated with an increased risk of liver cancer.
|
28978066 |
2017 |
|
rs843711
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs6713088 (G allele: odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.07-1.52, <i>P</i> = 0.007; GG vs. CC: OR = 1.49, 95% CI: 1.02-2.1, <i>P</i> = 0.038), rs843711 (T allele: OR = 1.29, 95% CI: 1.09-1.54, <i>P</i> = 0.004; TT vs. CC: OR = 1.62, 95% CI: 1.13-2.31, <i>P</i> = 0.008), rs843706 (A allele: OR = 1.30, 95% CI: 1.09-1.55, <i>P</i> = 0.003; AA vs. CC: OR = 1.62, 95% CI: 1.13-2.31, <i>P</i> = 0.008), and rs843645 (GG vs. AG: OR = 1.40, 95% CI: 1.07-1.82, <i>P</i> = 0.014) were associated with an increased risk of liver cancer.
|
28978066 |
2017 |
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rs843720
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population.
|
28978066 |
2017 |
|
rs843720
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the allele model, ACYP2 rs843720 was protection against the occurrence of cirrhosis developed into liver cancer (OR = 0.76, 95% CI: 0.58-0.99, p = 0.04).
|
31124313 |
2019 |
|
rs843706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs6713088 (G allele: odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.07-1.52, <i>P</i> = 0.007; GG vs. CC: OR = 1.49, 95% CI: 1.02-2.1, <i>P</i> = 0.038), rs843711 (T allele: OR = 1.29, 95% CI: 1.09-1.54, <i>P</i> = 0.004; TT vs. CC: OR = 1.62, 95% CI: 1.13-2.31, <i>P</i> = 0.008), rs843706 (A allele: OR = 1.30, 95% CI: 1.09-1.55, <i>P</i> = 0.003; AA vs. CC: OR = 1.62, 95% CI: 1.13-2.31, <i>P</i> = 0.008), and rs843645 (GG vs. AG: OR = 1.40, 95% CI: 1.07-1.82, <i>P</i> = 0.014) were associated with an increased risk of liver cancer.
|
28978066 |
2017 |
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rs4024
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|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
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rs737241
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|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
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rs12732894
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|
|
0.010 |
GeneticVariation |
BEFREE |
The genotyping analyses demonstrated a strong association of rs2244444 and rs12732894 with liver cancer.
|
30444969 |
2019 |
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rs2244444
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|
|
0.010 |
GeneticVariation |
BEFREE |
The genotyping analyses demonstrated a strong association of rs2244444 and rs12732894 with liver cancer.
|
30444969 |
2019 |
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rs113488022
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|
|
0.010 |
GeneticVariation |
BEFREE |
Melanoma cell line A375 with BRAF V600E point mutation exhibits higher FRET efficiency than liver cancer cell line HegG2 that was not reported having the mutation at this point.
|
29766713 |
2018 |
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rs121913377
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|
0.010 |
GeneticVariation |
BEFREE |
Melanoma cell line A375 with BRAF V600E point mutation exhibits higher FRET efficiency than liver cancer cell line HegG2 that was not reported having the mutation at this point.
|
29766713 |
2018 |
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rs1447295
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|
0.020 |
GeneticVariation |
BEFREE |
Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers.
|
18990762 |
2008 |
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rs1447295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In a dominant model, among those with a family history of cancer, rs1447295 was positively associated with liver cancer (OR(adj) 2.80; 95% CI 1.15-6.80).
|
24030569 |
2014 |
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rs187115
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0.010 |
GeneticVariation |
BEFREE |
Collectively, the CD44 rs187115 variant may be associated with the risk of cervical, lung, and liver cancer in the central Chinese population, and may be used as a potential biomarker for cancer predisposition in the Asian population, especially in the Chinese population.
|
30860617 |
2019 |
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rs2227306
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|
|
0.010 |
GeneticVariation |
BEFREE |
Our objective was to examine the association between single nucleotide polymorphisms of interleukin (IL)-8 (rs4073 and rs2227306) and IL-10 (rs1800871 and rs1800872) genes, and clinical effects of transcatheter arterial chemoembolization (TACE) and subsequent prognosis in patients with liver cancer.
|
26400525 |
2015 |
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rs4073
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|
0.010 |
GeneticVariation |
BEFREE |
Our objective was to examine the association between single nucleotide polymorphisms of interleukin (IL)-8 (rs4073 and rs2227306) and IL-10 (rs1800871 and rs1800872) genes, and clinical effects of transcatheter arterial chemoembolization (TACE) and subsequent prognosis in patients with liver cancer.
|
26400525 |
2015 |
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rs1330010954
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|
0.010 |
GeneticVariation |
BEFREE |
With RhoGAP-deficient DLC1 mutant (DLC1-K714E), we showed that the RhoGAP activity was essential for DLC1-mediated tumor suppressor function.
|
16204057 |
2005 |
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rs372894000
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0.010 |
GeneticVariation |
BEFREE |
With RhoGAP-deficient DLC1 mutant (DLC1-K714E), we showed that the RhoGAP activity was essential for DLC1-mediated tumor suppressor function.
|
16204057 |
2005 |
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rs756966085
|
|
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0.010 |
GeneticVariation |
BEFREE |
With RhoGAP-deficient DLC1 mutant (DLC1-K714E), we showed that the RhoGAP activity was essential for DLC1-mediated tumor suppressor function.
|
16204057 |
2005 |
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rs4444903
|
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|
0.020 |
GeneticVariation |
BEFREE |
The epidermal growth factor (EGF) rs4444903 A>G polymorphism has been associated with the development of liver cancer, which commonly complicates cirrhosis of viral origin; however, whether this polymorphism might be associated with fibrosis progression in chronic viral hepatitis is unknown.
|
22122913 |
2012 |