|
rs3746444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
35, 95% CI: 1.09-1.67), and rs3746444 was associated with liver cancer in the subgroup of cancer types.
|
23725137 |
2013 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A diagnosis of liver cancer or cirrhosis is rare in the lifetime of individuals from this population who are homozygous for the C282Y mutation (2.5%; upper 95% confidence interval (CI) = 8%).
|
10673304 |
2000 |
|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A number of previous studies have demonstrated that the HFE H63D polymorphism is associated with increased risk of incidence multiple types of cancer, including colorectal cancer, breast cancer, liver cancer, pancreatic cancer, and gynecological malignant tumors.
|
26535689 |
2015 |
|
rs28929474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to retrospective studies, up to 25% of those with homozygous ZZ (Glu 342 to Lys) AATD suffer from liver cirrhosis and/or liver cancer in late adulthood.
|
21617532 |
2011 |
|
rs28362491
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusted for potential confounding factors, rs28362491 ins/del or del/del genotypes were associated with higher risk of liver cancer with an adjusted OR 1.54 (95% CI 1.04 to 2.28). rs230496 AG and GG genotypes were also noted with higher risk of liver cancer with an adjusted OR 1.53 (95% CI 1.03 to 2.26).
|
24578542 |
2014 |
|
rs230496
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusted for potential confounding factors, rs28362491 ins/del or del/del genotypes were associated with higher risk of liver cancer with an adjusted OR 1.54 (95% CI 1.04 to 2.28). rs230496 AG and GG genotypes were also noted with higher risk of liver cancer with an adjusted OR 1.53 (95% CI 1.03 to 2.26).
|
24578542 |
2014 |
|
rs1801133
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After shrinkage and adjusting for potential confounding factors, we found positive associations between MTHFR rs1801133 and stomach cancer (any T versus C/C, SB odds-ratio [SBOR]: 1.79, 95% posterior limits: 1.18, 2.71) and liver cancer (SBOR: 1.51, 95% posterior limits: 0.98, 2.32).
|
25337902 |
2014 |
|
rs3787016
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Although no significant association was found for rs3787016 with risk of liver or lung cancer, the further stratified analysis identified that rs3787016 contributed to liver cancer risk particularly for over than 60 years individuals who drink.
|
30291213 |
2018 |
|
rs16901979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers.
|
18990762 |
2008 |
|
rs1447295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers.
|
18990762 |
2008 |
|
rs5854292
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Case-control studies assessing the relationship between TM6SF2 rs5854292 locus polymorphism and liver cancer were selected according to inclusion and exclusion criteria.
|
31752753 |
2019 |
|
rs187115
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Collectively, the CD44 rs187115 variant may be associated with the risk of cervical, lung, and liver cancer in the central Chinese population, and may be used as a potential biomarker for cancer predisposition in the Asian population, especially in the Chinese population.
|
30860617 |
2019 |
|
rs764555290
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further study on expression level and relevant functional significance enables us to identify and conclude the following four novel variants, viz., c.416T>C (p.Phe139Ser) in SORD, c.1048_1049delGCinsCG (p.Ala350Arg) in KRT6A, c.1159G>T (p.Gly387Cys) in SVEP1, and c.430G>C (p.Gly144Arg) in MRPL38 as a critical genetic factor for liver cancer.
|
31272500 |
2019 |
|
rs230525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis indicated that carriers of the NFKB1 GA and AA (rs230525-rs230530) haplotypes had higher risk of liver cancer under an additive model.
|
24578542 |
2014 |
|
rs230530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis indicated that carriers of the NFKB1 GA and AA (rs230525-rs230530) haplotypes had higher risk of liver cancer under an additive model.
|
24578542 |
2014 |
|
rs1051861187
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we report the first characterisation at the protein level of six ABCB4 variants (D243A, K435T, G535D, I490T, R545C, and S978P) previously found in patients with inflammatory liver diseases or liver cancer.
|
28220208 |
2017 |
|
rs3811741
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we found a significant association between rs3811741, located in the PLK4 intron, and liver cancer</span> risk (OR = 1.26, P = 9.81 × 10<sup>-5</sup> ).
|
31489978 |
2019 |
|
rs6983267
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Heterogeneity was observed (P(heterogeneity) = 0.029) with rs6983267 and liver cancer, with positive association in the dominant model among those with a family history of cancer and positive association in the recessive model among those without a family history of cancer.
|
24030569 |
2014 |
|
rs763569821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the frequency of primary liver carcinoma (PLC) with biliary differentiation, such as cholangiocarcinoma (CC) and combined hepatocholangiocarcinoma (CHCC), in GH remains unclear We analyzed the histologic type of 20 PLCs occurring in the background of GH; all patients were homozygotic for the C282Y mutation.
|
11710692 |
2001 |
|
rs1447295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In a dominant model, among those with a family history of cancer, rs1447295 was positively associated with liver cancer (OR(adj) 2.80; 95% CI 1.15-6.80).
|
24030569 |
2014 |
|
rs1801394
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, we detected potential heterogeneity across alcohol drinking status for ORs relating MTRR rs1801394 to esophageal (posterior homogeneity P = 0.005) and stomach cancer (posterior homogeneity P = 0.004), and ORs relating MTR rs1805087 to liver cancer (posterior homogeneity P = 0.021).
|
25337902 |
2014 |
|
rs1805087
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, we detected potential heterogeneity across alcohol drinking status for ORs relating MTRR rs1801394 to esophageal (posterior homogeneity P = 0.005) and stomach cancer (posterior homogeneity P = 0.004), and ORs relating MTR rs1805087 to liver cancer (posterior homogeneity P = 0.021).
|
25337902 |
2014 |
|
rs4444903
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the current meta-analysis suggests that the G variant of the rs4444903 polymorphism may increase</span> the risk of liver cancer.
|
25299191 |
2014 |
|
rs2853669
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we demonstrate a substantial role for the rs2853669 in HCC with TERT promoter mutation, which suggests that the combination of the rs2853669 and the mutation indicate poor prognoses in liver cancer.
|
26575952 |
2016 |
|
rs843720
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the allele model, ACYP2 rs843720 was protection against the occurrence of cirrhosis developed into liver cancer (OR = 0.76, 95% CI: 0.58-0.99, p = 0.04).
|
31124313 |
2019 |