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rs1046282
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results of clinicopathologic analysis showed that A allele at the rs737241 locus could increase the expression level of AFP (P = .007), the rs1046282 mutation C allele could increase the AFP expression level (P = .011), rs4024 locus mutation A allele could reduce the risk of vascular invasion (P = .013), rs3212948 locus mutation T allele could reduce the differentiation of liver cancer (P = .022), rs1046282 locus C allele could reduce the DNA load of hepatitis B virus (P = .035), and rs735482 A allele could increase the tumor size in HCC (P = .037).The SNPs in rs737241 for AFP gene may correlate with the occurrence of HCC.
|
30946366 |
2019 |
|
rs1051861187
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we report the first characterisation at the protein level of six ABCB4 variants (D243A, K435T, G535D, I490T, R545C, and S978P) previously found in patients with inflammatory liver diseases or liver cancer.
|
28220208 |
2017 |
|
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Melanoma cell line A375 with BRAF V600E point mutation exhibits higher FRET efficiency than liver cancer cell line HegG2 that was not reported having the mutation at this point.
|
29766713 |
2018 |
|
rs11614913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the miR-196a2 rs11614913 polymorphism may contribute to decreased susceptibility to cancer, especially including liver cancer and lung cancer.
|
24633889 |
2014 |
|
rs121912666
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PK9318, one of the most potent binders, restored p53 signaling in the liver cancer cell line HUH-7 with homozygous Y220C mutation.
|
31633398 |
2019 |
|
rs121913377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Melanoma cell line A375 with BRAF V600E point mutation exhibits higher FRET efficiency than liver cancer cell line HegG2 that was not reported having the mutation at this point.
|
29766713 |
2018 |
|
rs1234220
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TC genotype and C allele of rs1234220 polymorphism showed much more frequently in cases than in controls, reflecting that the TC genotype and the C allele may be linked to the increased risk of liver cancer (OR=2.225, 95% CI=1.178-4.204; OR=1.941, 95% CI=1.124-3.351).
|
26823866 |
2015 |
|
rs12732894
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotyping analyses demonstrated a strong association of rs2244444 and rs12732894 with liver cancer.
|
30444969 |
2019 |
|
rs1330010954
|
|
|
0.010 |
GeneticVariation |
BEFREE |
With RhoGAP-deficient DLC1 mutant (DLC1-K714E), we showed that the RhoGAP activity was essential for DLC1-mediated tumor suppressor function.
|
16204057 |
2005 |
|
rs1447295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers.
|
18990762 |
2008 |
|
rs1447295
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In a dominant model, among those with a family history of cancer, rs1447295 was positively associated with liver cancer (OR(adj) 2.80; 95% CI 1.15-6.80).
|
24030569 |
2014 |
|
rs1476081557
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We developed liver cancer cell lines that endogenously expressed a mutant form of TP53 (R249S) or overexpressed mutant forms of STAT3 (D170Y, K348E, and Y640F) or JAK1 (S703I and L910P) and tested the abilities of pharmacologic agents to reduce activity.
|
31560893 |
2019 |
|
rs1682111
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Rs1682111 and rs843720 play a protective role in the additive model (rs1682111: OR = 0.69, 95% CI: 0.52-0.93, p = 0.01; rs843720: OR = 0.73, 95% CI: 0.54-0.98, p = 0.04).While rs843645 G allele increased the risk of cirrhosis developed into liver cancer under the additive model (OR = 1.42, 95% CI: 1.02-2.00, p = 0.04).The haplotype analysis detected that "ATATCGCC" decreased the risk of cirrhosis developed into liver cancer (OR = 0.69, 95% CI: 0.51-0.92, 95% CI: p = 0.013); however, "TGAGCGTC" increased the risk of cirrhosis developed into liver cancer (OR = 1.48, 95% CI: 1.04-2.10, p = 0.027).
|
31124313 |
2019 |
|
rs1682111
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population.
|
28978066 |
2017 |
|
rs16901979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers.
|
18990762 |
2008 |
|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A number of previous studies have demonstrated that the HFE H63D polymorphism is associated with increased risk of incidence multiple types of cancer, including colorectal cancer, breast cancer, liver cancer, pancreatic cancer, and gynecological malignant tumors.
|
26535689 |
2015 |
|
rs1800469
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk factors for familial aggregation of liver cancer in Guangxi were determined, from high to low, to be: drinking sugared beverages > alcohol consumption > HBV DNA-positive > rs1800469 TT homozygous genotype > rs2241715 TT homozygous genotype.
|
26345741 |
2015 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A diagnosis of liver cancer or cirrhosis is rare in the lifetime of individuals from this population who are homozygous for the C282Y mutation (2.5%; upper 95% confidence interval (CI) = 8%).
|
10673304 |
2000 |
|
rs1800795
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer.
|
29842912 |
2018 |
|
rs1800797
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subgroup analyses of rs1800797 also suggested non-significant association and rs1800795 played a protective role in liver cancer.
|
29842912 |
2018 |
|
rs1800871
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our objective was to examine the association between single nucleotide polymorphisms of interleukin (IL)-8 (rs4073 and rs2227306) and IL-10 (rs1800871 and rs1800872) genes, and clinical effects of transcatheter arterial chemoembolization (TACE) and subsequent prognosis in patients with liver cancer.
|
26400525 |
2015 |
|
rs1800872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our objective was to examine the association between single nucleotide polymorphisms of interleukin (IL)-8 (rs4073 and rs2227306) and IL-10 (rs1800871 and rs1800872) genes, and clinical effects of transcatheter arterial chemoembolization (TACE) and subsequent prognosis in patients with liver cancer.
|
26400525 |
2015 |
|
rs1801131
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, Asian individuals with the homozygote genotype CC of MTHFR rs1801131 polymorphism are significantly associated with decreased risk of liver cancer.
|
24014085 |
2014 |
|
rs1801133
|
|
|
0.020 |
GeneticVariation |
BEFREE |
After shrinkage and adjusting for potential confounding factors, we found positive associations between MTHFR rs1801133 and stomach cancer (any T versus C/C, SB odds-ratio [SBOR]: 1.79, 95% posterior limits: 1.18, 2.71) and liver cancer (SBOR: 1.51, 95% posterior limits: 0.98, 2.32).
|
25337902 |
2014 |
|
rs1801133
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Therefore, MTHFR Ala222Val polymorphism is significantly associated with risk of hepatitis infection but not liver cancer</span>.
|
24155211 |
2014 |