|
rs763569821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, the frequency of primary liver carcinoma (PLC) with biliary differentiation, such as cholangiocarcinoma (CC) and combined hepatocholangiocarcinoma (CHCC), in GH remains unclear We analyzed the histologic type of 20 PLCs occurring in the background of GH; all patients were homozygotic for the C282Y mutation.
|
11710692 |
2001 |
|
rs3746444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
35, 95% CI: 1.09-1.67), and rs3746444 was associated with liver cancer in the subgroup of cancer types.
|
23725137 |
2013 |
|
rs230496
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusted for potential confounding factors, rs28362491 ins/del or del/del genotypes were associated with higher risk of liver cancer with an adjusted OR 1.54 (95% CI 1.04 to 2.28). rs230496 AG and GG genotypes were also noted with higher risk of liver cancer with an adjusted OR 1.53 (95% CI 1.03 to 2.26).
|
24578542 |
2014 |
|
rs230525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis indicated that carriers of the NFKB1 GA and AA (rs230525-rs230530) haplotypes had higher risk of liver cancer under an additive model.
|
24578542 |
2014 |
|
rs230530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis indicated that carriers of the NFKB1 GA and AA (rs230525-rs230530) haplotypes had higher risk of liver cancer under an additive model.
|
24578542 |
2014 |
|
rs28362491
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After adjusted for potential confounding factors, rs28362491 ins/del or del/del genotypes were associated with higher risk of liver cancer with an adjusted OR 1.54 (95% CI 1.04 to 2.28). rs230496 AG and GG genotypes were also noted with higher risk of liver cancer with an adjusted OR 1.53 (95% CI 1.03 to 2.26).
|
24578542 |
2014 |
|
rs16901979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Associations were observed between rs16901979 and upper aerodigestive tract cancer among never-smokers and between rs1447295 and liver cancer among ever-smokers.
|
18990762 |
2008 |
|
rs3811741
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein, we found a significant association between rs3811741, located in the PLK4 intron, and liver cancer</span> risk (OR = 1.26, P = 9.81 × 10<sup>-5</sup> ).
|
31489978 |
2019 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
These patients were followed-up and screened for the risk of HCC, and the influence of rs738409 on the occurrence of liver cancer was assessed using the Kaplan-Meier method, then according to the multivariate Cox model.
|
23069476 |
2013 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The PNPLA3 rs738409 148M/M genotype is a risk factor for liver cancer in alcoholic cirrhosis but shows no or weak association in hepatitis C cirrhosis.
|
22087248 |
2011 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The GG genotype of PNPLA3 rs738409 and the bAt (CCA) haplotype -associated with an increased risk of chronic liver disease and progression towards liver cancer- were significantly more frequent among samples exhibiting maternal and paternal Native American haplogroups (63.7 % and 64.6 %), intermediate among admixed samples (45.1 % and 44.9 %; p = 0.03) and the lowest for Non-native American ancestry (30.1 % and 29.6 %; p = 0.001 and p = 0.0008).
|
26219465 |
2015 |
|
rs738409
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Variation at rs738409 was not associated with significant changes in resolution rate of hepatitis C. By contrast, M/M genotype, present at higher frequencies (22.8%) in HCC patients than in patients with chronic hepatitis C (8.5%, P = 0.004) or control individuals (9.1%, P = 0.005) was associated with a 3-fold increase of liver cancer risk.
|
24269995 |
2014 |
|
rs3787016
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Although no significant association was found for rs3787016 with risk of liver or lung cancer, the further stratified analysis identified that rs3787016 contributed to liver cancer risk particularly for over than 60 years individuals who drink.
|
30291213 |
2018 |
|
rs3787016
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The rs3787016 polymorphism, in polymerase II polypeptide E (POLR2E), was previously identified as being associated with the risk for prostate cancer, esophageal cancer, breast cancer, papillary thyroid carcinoma and liver cancer, suggesting that rs3787016 may server as a common genetic factor to affect individual susceptibility to cancer.
|
30846411 |
2019 |
|
rs6983267
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We also observed a suggestive association between rs6983267 and liver cancer (ORadj, 1.51; 95% CI, 0.99-2.31).
|
18990762 |
2008 |
|
rs6983267
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Heterogeneity was observed (P(heterogeneity) = 0.029) with rs6983267 and liver cancer, with positive association in the dominant model among those with a family history of cancer and positive association in the recessive model among those without a family history of cancer.
|
24030569 |
2014 |
|
rs1234220
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TC genotype and C allele of rs1234220 polymorphism showed much more frequently in cases than in controls, reflecting that the TC genotype and the C allele may be linked to the increased risk of liver cancer (OR=2.225, 95% CI=1.178-4.204; OR=1.941, 95% CI=1.124-3.351).
|
26823866 |
2015 |
|
rs2299939
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To find out if there are any relationship between three single nucleotide polymorphisms (SNPs) of phosphatase and tensin homolog (PTEN) gene (rs1234213, rs1234220, and rs2299939) and the susceptibility of liver cancer.
|
26823866 |
2015 |
|
rs745501336
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Sanger DNA sequencing confirmed a mutation (c: 128810106C > T, p: A158T) occurred in one allele of Rab43 gene from the proband, that heterozygous mutation also was verified in the genome of the proband's deceased father with liver cancer, but not in his healthy mother and sister.
|
31226964 |
2019 |
|
rs28929474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to retrospective studies, up to 25% of those with homozygous ZZ (Glu 342 to Lys) AATD suffer from liver cirrhosis and/or liver cancer in late adulthood.
|
21617532 |
2011 |
|
rs2296651
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The S267F variant for the HBV cell-entry receptor NTCP was associated with increased resistance to HBV infection and decreased risk for cirrhosis and liver cancer among those with chronic HBV infection.
|
29905807 |
2018 |
|
rs769031989
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We developed liver cancer cell lines that endogenously expressed a mutant form of TP53 (R249S) or overexpressed mutant forms of STAT3 (D170Y, K348E, and Y640F) or JAK1 (S703I and L910P) and tested the abilities of pharmacologic agents to reduce activity.
|
31560893 |
2019 |
|
rs2853669
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, we demonstrate a substantial role for the rs2853669 in HCC with TERT promoter mutation, which suggests that the combination of the rs2853669 and the mutation indicate poor prognoses in liver cancer.
|
26575952 |
2016 |
|
rs2241715
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk factors for familial aggregation of liver cancer</span> in Guangxi were determined, from high to low, to be: drinking sugared beverages > alcohol consumption > HBV DNA-positive > rs1800469 TT homozygous genotype > rs2241715 TT homozygous genotype.
|
26345741 |
2015 |
|
rs1800469
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The risk factors for familial aggregation of liver cancer in Guangxi were determined, from high to low, to be: drinking sugared beverages > alcohol consumption > HBV DNA-positive > rs1800469 TT homozygous genotype > rs2241715 TT homozygous genotype.
|
26345741 |
2015 |