|
rs4282438
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Compared with subjects carrying variant genotypes (GG/TG) and non-HPV16 infections, those carrying wild-type genotype (TT) of rs4282438 and HPV16 positive had a 5.22-fold increased risk of cervical cancer (95 % CI = 3.39-8.04).
|
26711785 |
2016 |
|
rs4282438
|
|
|
0.730 |
GeneticVariation |
BEFREE |
In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population.
|
27193219 |
2016 |
|
rs4282438
|
|
|
0.730 |
GeneticVariation |
BEFREE |
No association was found with the two SNPs (rs4282438 or rs9277952) that were recently identified within the HLA-DP region in a cervical cancer GWAS in the Chinese population.
|
24743517 |
2014 |
|
rs13117307
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population.
|
27193219 |
2016 |
|
rs13117307
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We also observed associations of borderline significance with the TIPARP rs2665390 polymorphism, which was previously found to be associated with ovarian and breast cancer, and with the EXOC1 rs13117307 polymorphism, which has been linked to cervical cancer in a large study in a Chinese population.
|
28505207 |
2017 |
|
rs2516448
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The C allele of rs9272143 conferred protection against cervical cancer (odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.65-0.82; P = 1.6 × 10(-7)), which is associated with higher expression level of HLA-DRB1, whereas the T allele of rs2516448 increased the susceptibility to cervical cancer (OR = 1.33, 95% CI = 1.19-1.49; P = 5.8 × 10(-7)), with the same association shown with MICA-A5.1.
|
24403192 |
2014 |
|
rs2516448
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The cGAS-STING pathway in innate immunity plays an important role in protecting against HPV infection.Chen et al. described that the rs2516448 SNP in the MHC locus may affect susceptibility to cervical cancer, a finding that we attempted to replicate in a Chinese population.
|
27705945 |
2016 |
|
rs3117027
|
|
|
0.720 |
GeneticVariation |
BEFREE |
No association was observed between rs3117027 and risk of cervical cancer.
|
24403192 |
2014 |
|
rs3117027
|
|
|
0.720 |
GeneticVariation |
BEFREE |
<i>Conclusion.</i> HLA-DP gene polymorphisms (HLA-DPB1⁎03:01, DPB1⁎04:02, DPB1⁎13:01, rs9277535, and rs3117027) were significantly associated with cervical cancer.
|
30009173 |
2018 |
|
rs9272143
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Variation in LD between the classic HLA loci, rs9272143 and rs67841474 between populations may explain the different associations of HLA-B*07 and DRB1*1501-DQB1*0602 with cervical cancer between studies.
|
24520070 |
2014 |
|
rs9272143
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The C allele of rs9272143 conferred protection against cervical cancer (odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.65-0.82; P = 1.6 × 10(-7)), which is associated with higher expression level of HLA-DRB1, whereas the T allele of rs2516448 increased the susceptibility to cervical cancer (OR = 1.33, 95% CI = 1.19-1.49; P = 5.8 × 10(-7)), with the same association shown with MICA-A5.1.
|
24403192 |
2014 |
|
rs9277952
|
|
|
0.720 |
GeneticVariation |
BEFREE |
No association was found with the two SNPs (rs4282438 or rs9277952) that were recently identified within the HLA-DP region in a cervical cancer GWAS in the Chinese population.
|
24743517 |
2014 |
|
rs9277952
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population.
|
27193219 |
2016 |
|
rs2239704
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The rare allele (A) of SNP rs2239704 in the 5' UTR of the LTA gene was significantly associated with increased risks of cervical cancer (OR=1.31, 95% CI: 1.15-1.50; adjusted p-value: 0.013) and vulvar cancer (OR=1.51, 95% CI: 1.30-1.75; adjusted p-value: 1.9 × 10(-5) ).
|
23824834 |
2014 |
|
rs8067378
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population.
|
27193219 |
2016 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Driven by findings that human papillomavirus (HPV)-induced degradation of p53 differs by a TP53 polymorphism at codon 72 (Pro72Arg), past studies of TP53 genetic variants and cervical cancer have focused on this nonsynonymous polymorphism, with mixed results.
|
19423538 |
2009 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results indicated that the polymorphism in TP53 (rs1042522) might be associated with risk of cervical cancer development in HPV16 infected women.
|
23534750 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Arg variant of p53 Arg72Pro is associated with progression of SIL to cervical cancer only in the presence of HPV positivity.
|
23065429 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Women carrying the p53 Arg72Pro or p53 Pro72Pro increased the risk of cervical carcinoma (ORs and 95% CIs being 3.74 (2.65-5.30), 2.23 (1.49-3.34)).
|
19576684 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We failed to confirm earlier reports of increased cervical cancer susceptibility in women who harbor the p53 P72R allele.
|
12142377 |
2002 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present hospital-based retrospective cohort study aimed to evaluate the influence of <i>TP53</i> Arg72Pro (rs1042522) polymorphism in the clinical outcome of 260 Caucasian patients diagnosed with cervical cancer and treated with concomitant radiotherapy and chemotherapy.
|
29731921 |
2018 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the present study was to analyze the association of p53 codon72 (arginine/proline) polymorphism (rs1042522) and Murine Double Minute 2 (MDM2) SNP309 T/G (rs2279744) with the advancement of cervical cancer by using polymerase chain reaction-restriction fragment length polymorphism method followed by direct sequencing.
|
23210739 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To better understand the role of this polymorphism in cervical cancer etiology, we investigated the association between p53 R72P and cervical cancer risk in Chinese women from southern Han.
|
20193851 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A hundred HIV-infected women were examined for HPV detection and its genotypes, as well as the frequencies of the SNPs Arg72Pro and SNP309 and their associations with CC risk factors.
|
25181402 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Combined analysis revealed that the genotypes of rs4938723 CT/CC and TP53 Arg72Pro CG/CC had an increased cervical cancer risk (OR = 2.21, 95 % CI = 1.38-3.53).
|
26619844 |
2016 |