|
rs4846048
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The preliminary report revealed that the SNP rs4846048 of MTHFR enhanced the risk of CC through association with miR-522, which further regulated cell viability and apoptosis in Hela cells.
|
31750632 |
2020 |
|
rs55763075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PCR-DNA analysis was used to explore the genotype of the SNPs (rs4846048 and rs55763075) of the MTHFR 3'-UTR as well as the association between allelic frequencies and the CC risk.
|
31750632 |
2020 |
|
rs10426502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The stratified analysis showed that <i>TNFAIP8L1</i>-rs10426502, -rs1060555, and <i>FLT1</i>-rs9513111 were associated with a decreased risk of cervical cancer amongst people older than 43 years.
|
31289124 |
2019 |
|
rs1058808
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusions:</b> Our results suggested that the combination of <i>HER2</i> rs1136201and rs1058808 was significantly associated with the susceptibility of CCa.
|
30719131 |
2019 |
|
rs1060555
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The stratified analysis showed that <i>TNFAIP8L1</i>-rs10426502, -rs1060555, and <i>FLT1</i>-rs9513111 were associated with a decreased risk of cervical cancer amongst people older than 43 years.
|
31289124 |
2019 |
|
rs1143627
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our result revealed IL-1B rs1143627-AA (OR = 1.98, p = 0.029) and rs16944-GG (OR = 2.01, p = 0.025) was associated with an increased risk of cervical cancer.
|
31222982 |
2019 |
|
rs1143630
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype ″TGA″ in the block (rs1143630, rs1143627, and rs16944) significantly decreased the susceptibility of cervical cancer (OR = 0.53, p = 0.0007).
|
31222982 |
2019 |
|
rs11543848
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, the association between EGFR R497K (rs11543848) and -216G/T (rs712829) SNPs and radiochemotherapy response in cervical cancer was investigated.
|
31254173 |
2019 |
|
rs11568785
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariable logistic regression of cancer status in an over-dominant TGFB1 rs1800469/TGFBR1 rs11568785 model demonstrated a 3.03-fold reduction in cervical cancer odds.
|
31435875 |
2019 |
|
rs11655237
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicate that LINC00673 rs11655237 is associated with increased risk of cervical cancer, possibly by downregulating LINC00673 expression in cervical tissues.
|
30286619 |
2019 |
|
rs11674595
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, haplotype "T/A" of rs11674595/rs4851527 (adjusted OR = 0.73, 95% CI = 0.54-0.98, p = 0.037) and "T/C" of rs719250/rs3218896 (adjusted OR = 1.61, 95% CI = 1.10-2.36, p = 0.015) exhibited protective and risky effects for Uygur individuals on cervical cancer development, respectively.
|
30460760 |
2019 |
|
rs1195571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the individuals older than 43, rs4604006 (VEGF-C) was related to an increased cervical cancer risk under codominant model (p = .035), and rs12646659 was significantly associated with a reduced cervical cancer risk in allele, dominant, log-additive models (allele: p = .028; codominant: p = .037; log-additive: p = .037) However, there were no significant correlation of rs1000611 (VEGFR-2) and rs1195571 (VEGFR-3) with cervical cancer risk in Chinese Uygur population.
|
31478352 |
2019 |
|
rs12646659
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study firstly provided evidence that rs4604006 and rs12646659 of VEGF-C gene were related to the susceptibility of cervical cancer in Chinese Uygur population.
|
31478352 |
2019 |
|
rs1800587
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results also suggest a high risk of cancer susceptibility in patients carried rs1800587 polymorphism, of which draw out form allelic and homozygote models in overall studies, especially for cervical cancer.
|
31359795 |
2019 |
|
rs1927911
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CC and CT genotypes of TLR4 rs11536889 and rs1927911 respectively, and TC, CC genotypes of TLR9 rs187084, as well as minor alleles of TLR4 rs4986790 and TLR9 rs187084, were associated with the increased risk of cervical cancer.
|
31278284 |
2019 |
|
rs2043556
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because genetic variants in microRNAs (miRNAs) or their surrounding regions can alter miRNA processing, expression and final biological function, we investigated whether miRNA single-nucleotide polymorphisms (SNPs) are associated with cervical cancer (CC) susceptibility.Common miRNA SNPs (i.e. miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913, miR-499 rs3746444, miR-605 rs2043556 and miR-618 rs2682818) were genotyped in the 954 patients and 1339 controls.
|
30852614 |
2019 |
|
rs2227983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The R497K SNP might be a genetic marker for prediction of radiochemotherapy response and the risk of recurrence and/or metastasis in patients with cervical cancer.
|
31254173 |
2019 |
|
rs2292832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Therefore, the rs2292832 polymorphism might influence CC susceptibility through modulation of the procession of pre-miR-149 to mature miRNAs.
|
30852614 |
2019 |
|
rs2682818
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Because genetic variants in microRNAs (miRNAs) or their surrounding regions can alter miRNA processing, expression and final biological function, we investigated whether miRNA single-nucleotide polymorphisms (SNPs) are associated with cervical cancer (CC) susceptibility.Common miRNA SNPs (i.e. miR-146a rs2910164, miR-149 rs2292832, miR-196a2 rs11614913, miR-499 rs3746444, miR-605 rs2043556 and miR-618 rs2682818) were genotyped in the 954 patients and 1339 controls.
|
30852614 |
2019 |
|
rs2839698
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although genotypes TT in LncRNA H19 rs2839698 and GG in rs3741219 are related to some poor clinicopathological parameters of cervical cancer, only pelvic lymph node status could predict 5 year patient survival significantly.
|
31772651 |
2019 |
|
rs3218896
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, haplotype "T/A" of rs11674595/rs4851527 (adjusted OR = 0.73, 95% CI = 0.54-0.98, p = 0.037) and "T/C" of rs719250/rs3218896 (adjusted OR = 1.61, 95% CI = 1.10-2.36, p = 0.015) exhibited protective and risky effects for Uygur individuals on cervical cancer development, respectively.
|
30460760 |
2019 |
|
rs3219489
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings clearly highlight associations between the MUTYH Gln324His (CAG/CAC) polymorphism and susceptibility to CSCC, HR-HPV infection and specific prognostic factors, supporting the utility of this variant as an early indicator for patients at high risk of cervical carcinoma.
|
31027119 |
2019 |
|
rs3741219
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although genotypes TT in LncRNA H19 rs2839698 and GG in rs3741219 are related to some poor clinicopathological parameters of cervical cancer, only pelvic lymph node status could predict 5 year patient survival significantly.
|
31772651 |
2019 |
|
rs3787016
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Collectively, the POLR2E rs3787016 polymorphism may be a valuable biomarker for female breast and cervical cancer predisposition.
|
30846411 |
2019 |
|
rs42032
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs8179, rs42032, and rs42033 were associated with susceptibility to high-grade cervical cancer in different genetic models as well (p < 0.05).
|
30829464 |
2019 |