|
rs2516448
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The C allele of rs9272143 conferred protection against cervical cancer (odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.65-0.82; P = 1.6 × 10(-7)), which is associated with higher expression level of HLA-DRB1, whereas the T allele of rs2516448 increased the susceptibility to cervical cancer (OR = 1.33, 95% CI = 1.19-1.49; P = 5.8 × 10(-7)), with the same association shown with MICA-A5.1.
|
24403192 |
2014 |
|
rs2516448
|
|
|
0.720 |
GeneticVariation |
GWASCAT |
Three independent loci in the major histocompatibility complex (MHC) region at 6p21.3 were associated with cervical cancer: the first is adjacent to the MHC class I polypeptide-related sequence A gene (MICA) (rs2516448; OR = 1.42, 95% CI = 1.31 to 1.54; P = 1.6×10(-18)); the second is between HLA-DRB1 and HLA-DQA1 (rs9272143; OR = 0.67, 95% CI = 0.62 to 0.72; P = 9.3×10(-24)); and the third is at HLA-DPB2 (rs3117027; OR=1.25, 95% CI = 1.15 to 1.35; P = 4.9×10(-8)).
|
23482656 |
2013 |
|
rs2516448
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The cGAS-STING pathway in innate immunity plays an important role in protecting against HPV infection.Chen et al. described that the rs2516448 SNP in the MHC locus may affect susceptibility to cervical cancer, a finding that we attempted to replicate in a Chinese population.
|
27705945 |
2016 |
|
rs9277952
|
|
|
0.720 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.
|
23817570 |
2013 |
|
rs9277952
|
|
|
0.720 |
GeneticVariation |
BEFREE |
No association was found with the two SNPs (rs4282438 or rs9277952) that were recently identified within the HLA-DP region in a cervical cancer GWAS in the Chinese population.
|
24743517 |
2014 |
|
rs9277952
|
|
|
0.720 |
GeneticVariation |
BEFREE |
In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population.
|
27193219 |
2016 |
|
rs8067378
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In this study, associations between invasive cervical cancer and four cervical cancer susceptibility loci (rs13117307 at 4q12, rs8067378 at 17q12, and rs4282438 and rs9277952 at 6p21.32) in the Han Chinese population were investigated in a Japanese population.
|
27193219 |
2016 |
|
rs8067378
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
We identified strong evidence of associations between cervical cancer and two new loci: 4q12 (rs13117307, Pcombined, stringently matched=9.69×10(-9), per-allele odds ratio (OR)stringently matched=1.26) and 17q12 (rs8067378, Pcombined, stringently matched=2.00×10(-8), per-allele ORstringently matched=1.18).
|
23817570 |
2013 |
|
rs3132461
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study.
|
28806749 |
2017 |
|
rs6812281
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies four SNPs associated with response to platinum-based neoadjuvant chemotherapy for cervical cancer.
|
28120872 |
2017 |
|
rs73730372
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Pooled analysis of genome-wide association studies of cervical intraepithelial neoplasia 3 (CIN3) identifies a new susceptibility locus.
|
27285765 |
2016 |
|
rs9532669
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study.
|
28806749 |
2017 |
|
rs1195571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the individuals older than 43, rs4604006 (VEGF-C) was related to an increased cervical cancer risk under codominant model (p = .035), and rs12646659 was significantly associated with a reduced cervical cancer risk in allele, dominant, log-additive models (allele: p = .028; codominant: p = .037; log-additive: p = .037) However, there were no significant correlation of rs1000611 (VEGFR-2) and rs1195571 (VEGFR-3) with cervical cancer risk in Chinese Uygur population.
|
31478352 |
2019 |
|
rs180082
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This meta-analysis has shown that there is a lack of association of the Fas rs180082 polymorphisms with cervical cancer susceptibility.
|
23865866 |
2013 |
|
rs2808630
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The four most common single nucleotide gene polymorphisms CRP1919 (rs1417938), CRP2667 (rs1800947), CRP3872 (rs1205), and CRP5237 (rs2808630) were evaluated in 178 patients with cervical cancer.
|
21737650 |
2011 |
|
rs2844511
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A statistically significant association was observed between single nucleotide polymorphism (SNP) CHR6 rs2844511 and CC risk: the OR for carriers of the GA or GG genotypes was 0.70 (95% CI: 0.43-1.14) and 0.61 (95% CI: 0.38-0.98), respectively, relative to carriers of AA genotype (p-value for trend 0.03).
|
28505207 |
2017 |
|
rs4769793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Collectively, these findings suggested that STAT3 gene polymorphism (rs4769793) was associated with the susceptibility as well as poor differentiation and parametrial invasion of cervical cancer in Chinese women.
|
21668356 |
2011 |
|
rs6457617
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Persistent HPV16/18 infection in Indian women with the A-allele (rs6457617) of HLA-DQB1 and T-allele (rs16944) of IL-1β -511 is associated with development of cervical carcinoma.
|
25893807 |
2015 |
|
rs1800682
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Subgroup analysis by ethnicity suggested that there was no association between CD95 rs1800682 p</span>olymorphism and cervical cancer risk in Asians, Caucasians, and Africans.
|
24114012 |
2014 |
|
rs1800682
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, we did not observe any association between the cervical cancer risk and the rs2234767 and rs1800682 polymorphisms.
|
27790710 |
2017 |
|
rs2234767
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, we did not observe any association between the cervical cancer risk and the rs2234767 and rs1800682 polymorphisms.
|
27790710 |
2017 |
|
rs59661306
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study of cervical cancer suggests a role for ARRDC3 gene in human papillomavirus infection.
|
30412241 |
2019 |
|
rs1800624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, RAGE SNPs rs1800624 was associated with some clinicopathological variables in cervical cancer.
|
30410591 |
2018 |
|
rs9302648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of the SNPs after stratification based on CC clinical stage and subtype revealed that rs1048512, rs6659346, rs217727, rs9931702, and rs9302648 were associated with CC risk in clinical stages I-II; rs2862833, rs2732044, rs1030389, and rs1045935 were associated with CC risk in clinical stages III-IV; and rs217727, rs9931702, and rs9302648 were associated with CC risk in squamous carcinomas.
|
27765929 |
2016 |
|
rs9931702
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of the SNPs after stratification based on CC clinical stage and subtype revealed that rs1048512, rs6659346, rs217727, rs9931702, and rs9302648 were associated with CC risk in clinical stages I-II; rs2862833, rs2732044, rs1030389, and rs1045935 were associated with CC risk in clinical stages III-IV; and rs217727, rs9931702, and rs9302648 were associated with CC risk in squamous carcinomas.
|
27765929 |
2016 |