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rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
|
rs1801028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Neither the DRD2 S311C polymorphism nor the presence of long alleles for the DRD4 exon III repeat sequence was associated with psychosis or aggression.
|
9779662 |
1998 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Using a sample of sibling pairs discordant for psychosis, the authors attempted to replicate the findings of previous studies suggesting that the functional genetic polymorphism Val158Met in the catechol O-methyltransferase (COMT) gene influences prefrontal cognitive function and increases the risk for schizophrenia.
|
15169701 |
2004 |
|
rs1799971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A subdivision of our MAP group revealed that A118G of OPRM shows a significant association with MAP psychosis having latency less than three years.
|
15542732 |
2004 |
|
rs6280
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of D2-like dopamine receptor genes, DRD2 TaqI A, DRD3 Ser-9-Gly, and DRD4 exon III variable number of tandem repeats, were compared between: (a) MAMP users as a whole and 435 normal controls, and (b) those 154 individuals with MAMP-induced psychosis and the 252 MAMP users with no psychosis.
|
15564898 |
2004 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that the polymorphism (Ile105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population.
|
15729709 |
2005 |
|
rs104894685
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The authors identified a missense mutation in the FTL gene (474G>A; A96T) in a 19-year-old man with parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit, and episodic psychosis.
|
16116125 |
2005 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study.
|
16389585 |
2006 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with risk for psychosis: evidence from a family-based association study.
|
16389585 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond.
|
16476412 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The individual SNP analysis confirmed an association for the valine/methionine variant with AD-P. Haplotype analyses revealed that the alleles at four loci (rs737865, rs737864, intron 1 C2754delC, rs4680) interacted to create the risk of psychosis in AD, as A-C-C-G haplotype (OR=2.08, 95% CI=1.02-4.27, P=0.044) and G-C-delC-G haplotype (OR=2.54, 95% CI=1.32-4.90, P=0.006) in respect to the most common and not-at-risk A-C-C-A haplotype which was significantly overrepresented in AD-P.
|
16837108 |
2007 |
|
rs737864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The individual SNP analysis confirmed an association for the valine/methionine variant with AD-P. Haplotype analyses revealed that the alleles at four loci (rs737865, rs737864, intron 1 C2754delC, rs4680) interacted to create the risk of psychosis in AD, as A-C-C-G haplotype (OR=2.08, 95% CI=1.02-4.27, P=0.044) and G-C-delC-G haplotype (OR=2.54, 95% CI=1.32-4.90, P=0.006) in respect to the most common and not-at-risk A-C-C-A haplotype which was significantly overrepresented in AD-P.
|
16837108 |
2007 |
|
rs737865
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The individual SNP analysis confirmed an association for the valine/methionine variant with AD-P. Haplotype analyses revealed that the alleles at four loci (rs737865, rs737864, intron 1 C2754delC, rs4680) interacted to create the risk of psychosis in AD, as A-C-C-G haplotype (OR=2.08, 95% CI=1.02-4.27, P=0.044) and G-C-delC-G haplotype (OR=2.54, 95% CI=1.32-4.90, P=0.006) in respect to the most common and not-at-risk A-C-C-A haplotype which was significantly overrepresented in AD-P.
|
16837108 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition.
|
16936704 |
2006 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The objective of this study was to examine whether the functional genetic polymorphism Val158Met in the catechol-O-methyltransferase (COMT) gene influences cognitive deterioration in a sample of patients with psychosis under treatment with atypical antipsychotics.
|
16969277 |
2006 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To test the hypothesis that the T allele and the TT genotype are risk factors for psychosis, we genotyped the C677T polymorphism in 206 participants with schizophrenia or schizoaffective disorder and 359 participants from a population control sample.
|
16969279 |
2006 |
|
rs951436
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Specifically, variation at one RGS4 single nucleotide polymorphism that has been associated previously with psychosis (rs951436) impacts frontoparietal and frontotemporal blood oxygenation level-dependent response and network coupling during working memory and results in regionally specific reductions in gray and white matter structural volume in individuals carrying the A allele.
|
17301167 |
2007 |
|
rs6313
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Parent-of-origin effect and genomic imprinting of the HTR2A receptor gene T102C polymorphism in psychosis.
|
17407792 |
2007 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The findings suggest that the COMT(Val158Met) polymorphism moderates affective and psychotic responses to stress in patients with psychosis, providing evidence for gene-environment interaction mechanisms in the formation of psychotic symptoms.
|
17525974 |
2008 |
|
rs6313
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Subjects with possible or probable AD or mild cognitive impairment (MCI) without psychosis at study entry were genotyped for the HTR2A T102C polymorphism and reassessed every 6 months until psychosis onset.
|
17525976 |
2007 |
|
rs2619538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DTNBP1 showed significant associations with methamphetamine psychosis at polymorphisms of P1635 (rs3213207, p = .00003) and SNPA (rs2619538, p = .049) and the three-locus haplotype of P1655 (rs2619539)-P1635-SNPA (permutation p = .0005).
|
17555717 |
2008 |
|
rs2619539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DTNBP1 showed significant associations with methamphetamine psychosis at polymorphisms of P1635 (rs3213207, p = .00003) and SNPA (rs2619538, p = .049) and the three-locus haplotype of P1655 (rs2619539)-P1635-SNPA (permutation p = .0005).
|
17555717 |
2008 |
|
rs3213207
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DTNBP1 showed significant associations with methamphetamine psychosis at polymorphisms of P1635 (rs3213207, p = .00003) and SNPA (rs2619538, p = .049) and the three-locus haplotype of P1655 (rs2619539)-P1635-SNPA (permutation p = .0005).
|
17555717 |
2008 |
|
rs2076369
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of these SNPs, rs713729 was significantly associated with methamphetamine abusers in general, and rs713729 and rs2076369 were significantly associated with those with spontaneous relapse of psychosis.
|
17606663 |
2007 |
|
rs713729
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of these SNPs, rs713729 was significantly associated with methamphetamine abusers in general, and rs713729 and rs2076369 were significantly associated with those with spontaneous relapse of psychosis.
|
17606663 |
2007 |