|
rs2228145
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Asp358Ala was not associated with any of the other risk factors commonly linked with inflammation, depression or psychosis (all P > 0.20).
|
29197507 |
2018 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met) appears to influence cognition in people with alcohol/substance use disorders (AUD/SUD) and in those with psychosis.
|
28635556 |
2017 |
|
rs2239547
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A history of suicide attempt was assessed in a sample of 1009 patients with BD, SCZ and related psychosis spectrum disorders, and associations with the joint genetic risk variants for BD and SCZ (rs2239547 (ITIH3/4-region), rs10994359 (ANK3) and rs4765905 (CACNA1C)) were investigated.
|
24461634 |
2014 |
|
rs10994359
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A history of suicide attempt was assessed in a sample of 1009 patients with BD, SCZ and related psychosis spectrum disorders, and associations with the joint genetic risk variants for BD and SCZ (rs2239547 (ITIH3/4-region), rs10994359 (ANK3) and rs4765905 (CACNA1C)) were investigated.
|
24461634 |
2014 |
|
rs4765905
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A history of suicide attempt was assessed in a sample of 1009 patients with BD, SCZ and related psychosis spectrum disorders, and associations with the joint genetic risk variants for BD and SCZ (rs2239547 (ITIH3/4-region), rs10994359 (ANK3) and rs4765905 (CACNA1C)) were investigated.
|
24461634 |
2014 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A putative interaction between cannabis and variation at rs4680 within the catechol-methyl-transferase (COMT) gene on psychosis has been reported, but not adequately replicated.
|
21947654 |
2011 |
|
rs6994992
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) increases the risk of psychosis, affects prefrontal activation and structural connectivity in the brain, and is related to the expression of a specific neuregulin 1 isoform.
|
18543275 |
2009 |
|
rs1799971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A subdivision of our MAP group revealed that A118G of OPRM shows a significant association with MAP psychosis having latency less than three years.
|
15542732 |
2004 |
|
rs3800373
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After analyzing the FKBP5 gene for single nucleotide polymorphisms, we found that rs3800373 CC genotype is more frequent in the MDD and MDD/Psychosis groups.
|
19199039 |
2009 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis.
|
23799032 |
2013 |
|
rs2709722
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the association of rs2709722 in Sp8 transcription factor (SP8) was suggestive in the Asian population (P = 2.1×10(-7) for psychosis), this signal weakened when the samples size was increased by including data from a Caucasian population (P = 4.3×10(-3)).
|
23967141 |
2013 |
|
rs502434
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An association of GRIA3 rs502434 was identified with both METH dependence and METH-dependent psychosis, although this did not withstand correction for multiple testing.
|
29338492 |
2018 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition.
|
16936704 |
2006 |
|
rs1341402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Assessment of nine common variants in the DAOA/G72 locus yielded two variants with the predictive value for symptom progression: all four probands with the rs1341402 CC genotype developed psychosis compared with 17 out of 78 probands with the TT or CT genotypes (chi(2) = 12.348; df = 2; p = 0.002).
|
19763662 |
2010 |
|
rs1800955
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Baseline clinical, psychosis-risk status, cognitive, neurological-soft-signs measures, and dopamine-related-gene polymorphisms (DRD1-rs4532, COMT-rs165599, and DRD4-rs1800955) were collected in 138 young non-psychotic outpatients.
|
28041918 |
2017 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Because of its role in catecholamine metabolism and several lines of evidence pointing to a locus for psychosis near the COMT gene on chromosome 22q11, we have analysed the COMT Val158Met polymorphism as a candidate susceptibility factor for bipolar affective disorder.
|
9352569 |
1997 |
|
rs1039002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Bipolar disorder with psychosis and/or substance abuse in the absence of alcohol dependence was associated with the rare variant rs1039002 in the vicinity of the gene phosphodiesterase 10A (PDE10A) on chromosome 6q27 (p = 1.7×10⁻⁸).
|
22205951 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met polymorphism.
|
21231925 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond.
|
16476412 |
2006 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome.
|
31822818 |
2019 |
|
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome.
|
31822818 |
2019 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
COMT Val158Met-stress interaction in psychosis: role of background psychosis risk.
|
21073668 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions.
|
27052366 |
2016 |
|
rs6465084
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Despite limited literature, studies demonstrated: single nucleotide polymorphisms (SNPs) associated with BD, including a GRM3 SNP associated with greater likelihood of psychosis (rs6465084), mRNA binding protein Fragile X Mental Retardation Protein associated with altered mGluR1/5 activity in BD populations, and lithium decreasing mGluR5 expression and mGluR-mediated intracellular calcium signaling.
|
28800512 |
2017 |
|
rs1801133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Disorganization is associated with early schizophrenia onset and history of psychosis in family, low level of insight and compliance, high risk of committing delicts, distraction errors in WCST, lengthened P300 latency of evoked cognitive auditory potentials, low-functional alleles of genes MTHFR (rs1801133) and DNMT3b (rs2424913), high level of urbanicity and psychotraumatic events at early age.
|
28192769 |
2017 |